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Listar por palabra clave "Phototoxicity"

Mostrando ítems 1-13 de 13

Alkylation of a hydrophilic photosensitizer enhances the contact-dependent photo-induced oxidation of phospholipid membranes

Vignoni, Alejandro; Layana, Carla; Junqueira, Helena C.; Thomas, Andrés H.; Itri, Rosangela; Baptista, Mauricio S.; Vignoni, Mariana (Elsevier, 2021-03)

[EN] Lipophilic photosensitizers able to photo-induce lipid oxidation in biomembranes are, in general, much more efficient than hydrophilic ones; acting through the formation of singlet oxygen (O-1(2)), which oxidizes the ...
Assessment of the PARP inhibitor talazoparib photosafety profile

Mateos-Pujante, Alejandro; Jiménez, M Consuelo; Andreu, Inmaculada (Elsevier, 2023-11)

[EN] Talazoparib (TLZ) is a poly(adenosine diphosphate [ADP]-ribose) polymerase inhibitor employed for the treatment of breast cancer. This drug displays an absorption band in the UVA region, and therefore investigation ...
Design of New Up-conversion Systems for Anticancer Therapies

Anaya González, Cristina (Universitat Politècnica de València, 2021-07-19)

[ES] El cáncer es una de las principales causas de muerte a nivel mundial. Los tratamientos anticancerígenos generalmente usados tienen diversos efectos secundarios producidos por su baja especificidad. Esta es una de las ...
Enhanced photo(geno)toxicity of demethylated chlorpromazine metabolites

Palumbo, Fabrizio; García Lainez, Guillermo; Limones Herrero, Daniel; Coloma, María Dolores; Escobar, Javier; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada (Elsevier, 2016)

Chlorpromazine (CPZ) is an anti-psychotic drug widely used to treat disorders such as schizophrenia or manic-depression. Unfortunately, CPZ exhibits undesirable side effects such as phototoxic and photoallergic reactions ...
Estudio de la foto(geno)toxicidad del diclofenaco y sus metabolitos

Martínez Reig, Ana María (Universitat Politècnica de València, 2017-08-30)

The diclofenac is a drug widely used for relieving mild to moderate pain that can be used in tablet forms as well as in gel for topical treatment. Exposure to sunlight after diclofenac administration is associated with an ...
Estudio fotoquímico y fotofísico del ansiolítico clordiazepóxido y su metabolito demoxepam

Moreno Roig, Gema (Universitat Politècnica de València, 2021-10-21)

[ES] El clordiazepóxido es un fármaco que pertenece al grupo de las benzodiazepinas y se utiliza para tratar problemas asociados a la ansiedad. En relación a la biotransformación de fármacos, esta se asocia a una mayor ...
Estudio fotoquímico y fotofísico del fármaco sulfasalazina en medios biomiméticos

García Gimeno, Belén (Universitat Politècnica de València, 2021-10-06)

[ES] La sulfasalazina (SSZ) es un fármaco empleado para el tratamiento de la artritis reumatoide, la colitis ulcerosa y la enfermedad de Crohn. Entre otras reacciones adversas asociadas a este fármaco se han descrito los ...
Evaluación del potencial fotoquímico y fotobiológico de los inhibidores de la poli (ADP-ribosa) polimerasa

Mateos Pujante, Alejandro (Universitat Politècnica de València, 2023-09-07)

[ES] En la presente tesis doctoral se ha desarrollado una metodología multidisciplinar para la evaluación del potencial fotoquímico y fotobiológico in vitro de los fármacos inhibidores de la poli (ADP-ribosa) polimerasa ...
In Vitro Photobehavior of Tyrosine Kinase Inhibitors in Solution and within Skin Cells

Ouardi el Hamidy, Meryem el (Universitat Politècnica de València, 2024-07-11)

[ES] En las últimas décadas, la aprobación de los inhibidores de la tirosina quinasa (del inglés TKI) como una nueva clase de terapia dirigida ha mejorado la calidad de vida y las tasas de supervivencia de los pacientes ...
MECHANISTIC STUDIES ON THE PHOTOTOXICITY OF ROSUVASTATIN, ITRACONAZOLE AND IMATINIB

Nardi, Giacomo (Universitat Politècnica de València, 2015-03-31)

Photosensitizing effects of xenobiotics are of increasing concern in public health since modern lifestyle often associates sunlight exposure with the presence of chemical substances in the skin. An important number of ...
Photo(geno)toxicity changes associated with hydroxylation of the aromatic chromophores during diclofenac metabolism

García -Laínez, Guillermo; Ana M Marínez-Reig; Limones Herrero, Daniel; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada (Elsevier, 2018)

[EN] Diclofenac (DCF) can cause adverse reactions such as gastrointestinal, renal and cardiovascular disorders; therefore, topical administration may be an attractive alternative to the management of local pain in order ...
Singlet oxygen production and in vitro phototoxicity studies on fenofibrate, mycophenolate mofetil, trifusal, and their active metabolites

Molins-Molina, Oscar; Bresolí-Obach, Roger; García-Laínez, G.; Andreu Ros, María Inmaculada; Nonell, Santiago; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo (John Wiley & Sons, 2017-09)

[EN] Singlet oxygen photosensitization (studied by time-resolved near-infrared emission spectroscopy) and in vitro phototoxicity (by means of the 3T3 neutral red uptake assay) have been investigated for the prodrugs ...
Sunscreen-Based Photocages for Topical Drugs: A Photophysical and Photochemical Study of A Diclofenac-Avobenzone Dyad

Aparici-Espert, Maria Isabel; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria (MDPI AG, 2018-03)

[EN] Photosensitization by drugs is a problem of increasing importance in modern life. This phenomenon occurs when a chemical substance in the skin is exposed to sunlight. Photosensitizing drugs are reported to cause severe ...