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Diseño racional y caracterización de nanodispositivos de sílice mesoporosa para liberación controlada en células senescentes

Bou Puerto, Regina (Universitat Politècnica de València, 2015-09-07)

[EN] The main objective of this TFG is the development and validation in various senescent cell models of mesoporous silica materials (MSN) synthesized and functionalized with molecular gates, that can release the load ...
Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

González-Gualda, Estela; Pàez-Rives, Marta; Lozano-Torres, Beatriz; Macias, David; Wilson III, Joseph R.; González-López, Cristina; Ou, Hui-Ling; MIrón-Barroso, Sofía; Zhang, Zhenguang; Lérida-Viso, Araceli; Blandez, Juan F.; Bernardos Bau, Andrea; Sancenón Galarza, Félix; Rovira, Miguel; Fruk, Ljiljana; Martins, Carla P.; Serrano, Manuel; Doherty, Gary J.; Martínez-Máñez, Ramón; Muñoz-Espín, Daniel (Blackwell Publishing, 2020-04)

[EN] Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse ...

Mostrando ítems 1-2 de 2