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Amidase-responsive controlled release of antitumoral drug into intracellular media using gluconamide-capped mesoporous silica nanoparticles

Candel Busquets, Inmaculada; Aznar Gimeno, Elena; Mondragón Martínez, Laura; De la Torre Paredes, Cristina; Martínez Mañez, Ramón; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Amoros del Toro, Pedro Jose; Guillem, Carmen; Pérez Payá, Enrique; Costero Nieto, Ana María; Gil Grau, Salvador; Parra Álvarez, Margarita (Royal Society of Chemistry, 2012-10-02)

MCM-41 silica nanoparticles were used as inorganic scaffolding to prepare a nanoscopic-capped hybrid material S1, which was able to release an entrapped cargo in the presence of certain enzymes, whereas in the absence of ...
Selective opening of nanoscopic capped mesoporous inorganic materials with nerve agent simulants; an application to design chromo-fluorogenic probes

Candel Busquets, Inmaculada; Bernardos Bau, Andrea; Climent Terol, Estela; Marcos Martínez, María Dolores; Martínez Mañez, Ramón; Sancenón Galarza, Félix; Soto Camino, Juan; Costero, Ana; Gil Grau, Salvador; Parra Álvarez, Margarita (Royal Society of Chemistry, 2011)

A hybrid nanoscopic capped mesoporous material, that is selectively opened in the presence of nerve agent simulants, has been prepared and used as a probe for the chromo-fluorogenic detection of these chemicals. © 2011 The ...

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