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Listar por palabra clave "Single-molecule"

Mostrando ítems 1-6 de 6

DNA synthesis determines the binding mode of the human mitochondrial single-stranded DNA-binding protein

Morin, J.A.; Cerrón, F.; Jarillo, J.; Beltran-Heredia, E.; Ciesielski, G.L.; Arias-Gonzalez, J. R.; Kaguni, L.S.; Cao, F.J.; Ibarra, B. (Oxford University Press, 2017-07-07)

[EN] Single-stranded DNA-binding proteins (SSBs) play a key role in genome maintenance, binding and organizing single-stranded DNA (ssDNA) intermediates. Multimeric SSBs, such as the human mitochondrial SSB (HmtSSB), present ...
Mechanical Identities of RNA and DNA Double Helices Unveiled at the Single-Molecule Level

Herrero-Galán, E.; Fuentes-Perez. M.E.; Carrasco, C.; Valpuesta, J.M.; Carrascosa, J.L.; Moreno-Herrero, F.; Arias-Gonzalez, J. R. (American Chemical Society, 2013-01-09)

[EN] Double-stranded (ds) RNA is the genetic material of a variety of viruses and has been recently recognized as a relevant molecule in cells for its regulatory role. Despite that the elastic response of dsDNA has been ...
Mechanical unfolding of long human telomeric RNA (TERRA)

Garavís, M.; Bocanegra, R.; Herrero-Galán, E.; González, C.; Villasante, A.; Arias-Gonzalez, J. R. (The Royal Society of Chemistry, 2013)

[EN] We report the first single molecule investigation of TERRA molecules. By using optical-tweezers and other biophysical techniques, we have found that long RNA constructions of up to 25 GGGUUA repeats form higher order ...
Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase

Morin, J.A.; Cao, F.J.; Lázaro, J.M.; Arias-Gonzalez, J. R.; Valpuesta, J.M.; Carrascosa, J.L.; Salas, M.; Ibarra, B. (Oxford University Press, 2015-04-20)

[EN] During DNA replication replicative polymerases move in discrete mechanical steps along the DNA template. To address how the chemical cycle is coupled to mechanical motion of the enzyme, here we use optical tweezers ...
Single-molecule portrait of DNA and RNA double helices

Arias-Gonzalez, J. R. (Oxford University Press, 2014-10)

[EN] The composition and geometry of the genetic information carriers were described as double-stranded right helices sixty years ago. The flexibility of their sugar¿phosphate backbones and the chemistry of their nucleotide ...
Single-Stranded Condensation Stochastically Blocks G-Quadruplex Assembly in Human Telomeric RNA

Gutiérrez, I.; Garavís, M.; de Lorenzo, S.; Villasante, A.; González, C.; Arias-Gonzalez, J. R. (American Chemical Society, 2018-05-17)

[EN] TERRA is an RNA molecule transcribed from human subtelomeric regions toward chromosome ends potentially involved in regulation of heterochromatin stability, semiconservative replication, and telomerase inhibition, ...