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Bioequivalence risk assessment of oral formulations containing racemic ibuprofen through a chiral physiologically based pharmacokinetic model of ibuprofen enantiomers

Reig-López, Javier; M. Cuquerella-Gilabert; Bandín-Vilar, Enrique; Merino-Sanjuán, Matilde; Mangas-Sanjuán, Victor; García-Arieta, Alfredo (Elsevier, 2024-06)

[EN] The characterization of the time course of ibuprofen enantiomers can be useful in the selection of the most sensitive analyte in bioequivalence studies. Physiologically based pharmacokinetic (PBPK) modelling and ...
Regio- and Stereoselective Synthesis of 3-Pyrazolylidene-2-oxindole Compounds by Nucleophilic Vinylic Substitution of (E)-3-(Nitromethylene)indolin-2-one

Vila, C.; Slack, S.; Blay, G.; Muñoz Roca, María Del Carmen; Pedro, J. R. (John Wiley & Sons, 2019-04-16)

[EN] A highly regio- and stereoselective synthesis of 3-alkylidene-2-oxindoles has been described through a nucleophilic vinylic substitution (SNV) of (E)-3-(nitromethylene)indolin-2-one using pyrazol-3-ones as nucleophiles ...

Mostrando ítems 1-2 de 2