Introduction: The vascular endothelial growth factor (VEGF) family of ligands and receptors (VEGFR) play an important role in tumor angiogenesis. Increased expression of angiogenic factors in tumors or in blood is associated ...
[EN] We have engineered polymer-based microenvironments that promote vasculogenesis both in vitro and in vivo through synergistic integrin-growth factor receptor signalling. Poly(ethyl acrylate) (PEA) triggers spontaneous ...
[EN] Background: In advanced-stage (IIIB or IV) non-small-cell lung cancer (NSCLC), combination chemotherapy has demonstrated response rates of 20% and a 1-year survival rate of 30%. We conducted a multicentre, open-label, ...
Jantus-Lewintre, Eloisa; Massuti Sureda, Bartomeu; Gonzalez Larriba, Jose Luis; Rodríguez-Abreu, Delvys; Juan, Oscar; Blasco, Ana; Domine, Manuel; Provencio Pulla, Mariano; Garde, Javier; Alvarez, Rosa; Maestu, Inmaculada; Perez de Carrion, Ramon; Artal, Angel; Rolfo, Christian; de Castro, Javier; Camps, Carlos(Frontiers Media SA, 2021-07-26)
[EN] Finding angiogenic prognostic markers in advanced non-small-cell lung cancer is still an unmet medical need. We explored a set of genetic variants in the VEGF-pathway as potential biomarkers to predict clinical outcomes ...
[EN] Boron ion is essential in metabolism and its concentration is regulated by ion-channel NaBC1. NaBC1 mutations cause corneal dystrophies such as Harboyan syndrome. Here we propose a 3D molecular model for NaBC1 and ...