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Listar por palabra clave "Virus evolution"

Mostrando ítems 1-20 de 30

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2b or not 2b: experimental evolution of functional exogenous sequences in a plant RNA virus

Willemsen, Anouk; Zwart, Mark Peter; Ambros Palaguerri, Silvia; Carrasco Jiménez, José Luis; Elena Fito, Santiago Fco (Oxford University Press, 2017)

[EN] Horizontal gene transfer (HGT) is pervasive in viruses and thought to be a key mechanism in their evolution. On the other hand, strong selective constraints against increasing genome size are an impediment for HGT, ...
A putative antiviral role of plant cytidine deaminases

Martín, Susana; Cuevas, J.M.; Grande-Perez, A.; Elena Fito, Santiago Fco (F1000 Research, Ltd., 2017)

[EN] Background: A mechanism of innate antiviral immunity operating against viruses infecting mammalian cells has been described during the last decade. Host cytidine deaminases (e.g., APOBEC3 proteins) edit viral genomes, ...
Assessing parallel gene histories in viral genomes

Mengual-Chuliá, Beatriz; Bedhomme, Stephanie; Lafforgue, Guillaume; Elena Fito, Santiago Fco; Bravo, Ignacio G. (BioMed Central, 2016-02-05)

Background: The increasing abundance of sequence data has exacerbated a long known problem: gene trees and species trees for the same terminal taxa are often incongruent. Indeed, genes within a genome have not all followed ...
CRISPR-Cas12a-Based Detection of SARS-CoV-2 Harboring the E484K Mutation

Marqués, María-Carmen; Ruiz, Raúl; Montagud-Martínez, Roser; Márquez-Costa, Rosa; Albert, Sandra; Domingo-Calap, Pilar; Rodrigo Tarrega, Guillermo (American Chemical Society, 2021-12-17)

[EN] The novel respiratory virus SARS-CoV-2 is rapidly evolving across the world with the potential of increasing its transmission and the induced disease. Here, we applied the CRISPR-Cas12a system to detect, without ...
Efficient escape from local optima in a highly rugged fitness landscape by evolving RNA virus populations

Cervera-Benet, Héctor; Lalic, Jasna; Elena Fito, Santiago Fco (Royal Society, The, 2016-07-17)

[EN] Predicting viral evolution has proven to be a particularly difficult task, mainly owing to our incomplete knowledge of some of the fundamental principles that drive it. Recently, valuable information has been provided ...
Epistasis between mutations is host-dependent for an RNA virus

Lalic ., Jasna; Elena Fito, Santiago Fco (Royal Society, The, 2012)

How, and to what extent, does the environment influence the way mutations interact? Do environmental changes affect both the sign and the magnitude of epistasis? Are there any correlations between environments in the ...
Evolution and emergence of plant viruses

Elena Fito, Santiago Fco; Fraile, Aurora; García-Arena, Fernando (Elsevier (according to Zetoc), 2014)

[EN] Viruses are common agents of plant infectious diseases. During last decades, worldwide agriculture production has been compromised by a series of epidemics caused by new viruses that spilled over from reservoir species ...
Evolutionary transitions during RNA virus experimental evolution

Elena Fito, Santiago Fco (Royal Society, The, 2016-08-19)

[EN] In their search to understand the evolution of biological complexity, John Maynard Smith and Eors Szathmary put forward the notion of major evolutionary transitions as those in which elementary units get together to ...
Experimental evolution of an emerging plant virus in host genotypes that differ in their susceptibility to infection

Hillung, Julia; Cuevas Torrijos, Jose Manuel; Valverde, Sergi; Elena Fito, Santiago Fco (Wiley, 2014-09)

[EN] This study evaluates the extent to which genetic differences among host individuals from the same species condition the evolution of a plant RNA virus. We performed a threefold replicated evolution experiment in which ...
Genetic variation in fitness within a clonal population of a plant RNA virus

Cervera-Benet, Héctor; Elena Fito, Santiago Fco (Oxford University Press (OUP), 2016-01)

[EN] A long-standing observation in evolutionary virology is that RNA virus populations are highly polymorphic, composed by a mixture of genotypes whose abundances in the population depend on complex interaction between ...
High virulence does not necessarily impede viral adaptation to a new host: a case study using a plant RNA virus

Willemsen, Anouk; Zwart, Mark Peter; Elena Fito, Santiago Fco. (Springer (Biomed Central Ltd.), 2017)

[EN] Background: Theory suggests that high virulence could hinder between-host transmission of microparasites, and that virulence therefore will evolve to lower levels. Alternatively, highly virulent microparasites could ...
Intra-specific variability and biological relevance of P3N-PIPO protein length in potyviruses

Hillung, Julia; Elena Fito, Santiago Fco; Cuevas Torrijos, Jose Manuel (BioMed Central, 2013-11-13)

Background: Pipo was recently described as a new ORF encoded within the genome of the Potyviridae family members (PNAS 105: 5897-5902, 2008). It is embedded within the P3 cistron and is translated in the +2 reading frame ...
Local adaptation of plant viruses: lessons from experimental evolution

Elena Fito, Santiago Fco. (Blackwell Publishing, 2017)

[EN] For multihost pathogens, adaptation to multiple hosts has important implications for both applied and basic research. At the applied level, it is one of the main factors determining the probability and severity of ...
Magnitude and sign epistasis among deleterious mutations in a positive-sense plant RNA virus

Lalic, Jasna; Elena Fito, Santiago Fco (Nature Publishing Group, 2012-08)

How epistatic interactions between mutations determine the genetic architecture of fitness is of central importance in evolution. The study of epistasis is particularly interesting for RNA viruses because of their genomic ...
Matters of Size: Genetic Bottlenecks in Virus Infection and Their Potential Impact on Evolution

Zwart, Mark Peter; Elena Fito, Santiago Fco (Annual Reviews, 2015)

For virus infections of multicellular hosts, narrow genetic bottlenecks during transmission and within-host spread appear to be widespread. These bottlenecks will affect the maintenance of genetic variation in a virus ...
Molecular evolution of Pepino mosaic virus during long-term passaging in different hosts and its impact on virus virulence

Minicka, J; Rymelska, N; Elena Fito, Santiago Fco; Czerwoniec, A; Hasiów-Jaroszewska, B (Wiley, 2015-05)

In this study the effect of host changes and multiple passages on Pepino mosaic virus (PepMV) evolution was analysed. A population of a mild isolate of PepMV was used to generate five independent evolution lineages on three ...
Molecular evolution of viral multifunctional proteins: the case of Potyvirus HC-Pro

Hasiów-Jaroszewska, Beata; Fares Riaño, Mario Ali; Elena Fito, Santiago Fco (Springer Verlag (Germany), 2014-01)

[EN] Our knowledge on the mode of evolution of the multifunctional viral proteins remains incomplete. To tackle this problem, here, we have investigated the evolutionary dynamics of the potyvirus multifunctional protein ...
Onset of virus systemic infection in plants is determined by speed of cell-to-cell movement and number of primary infection foci

Rodrigo Tarrega, Guillermo; Zwart, Mark Peter; Elena Fito, Santiago Fco (Royal Society Publishing, 2014-09-06)

The cornerstone of today's plant virology consists of deciphering the molecular and mechanistic basis of host-pathogen interactions. Among these interactions, the onset of systemic infection is a fundamental variable in ...
Optimal viral strategies for bypassing RNA silencing

Rodrigo Tarrega, Guillermo; Carrera, Javier; Jaramillo, Alfonso; Elena Fito, Santiago Fco (Royal Society, The, 2011-02-06)

[EN] The RNA silencing pathway constitutes a defence mechanism highly conserved in eukaryotes, especially in plants, where the underlying working principle relies on the repressive action triggered by the intracellular ...
Phylodynamics of Pepino mosaic virus in Spain

Gomez, P.; Sempere, R.N.; Aranda, M.A.; Elena Fito, Santiago Fco (Springer Verlag (Germany), 2012-11)

[EN] Pepino mosaic virus (PepMV) is an emerging pathogen that causes severe economic losses in tomato crops in the Northern hemisphere. After its first identification, the new viral strain PepMV-CH2 has been isolated in ...