While most of the in vivo extracellular matrices are 3D, most of the in vitro cultures are 2D--where only ventral adhesion is permitted--thus modifying cell behavior as a way to self-adaptation to this unnatural environment. ...
Morata Martínez, Miranda(Universitat Politècnica de València, 2018-09-18)
[EN] The cellular response to biomaterials is mediated not only by the innate material properties but also
by different parameters of the interface protein layer on the surface of materials, such as their
conformation ...