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Mostrando ítems 1-6 de 6

Drug-drug interactions within protein cavities probed by triplet-triplet energy transfer

Nuin Plá, Neus Edurne; Jiménez Molero, María Consuelo; Sastre Navarro, German Ignacio; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel (American Chemical Society, 2013-05-16)

A new direct and noninvasive methodology based on transient absorption spectroscopy has been developed to probe the feasibility of drug-drug interactions within a common protein binding site. The simultaneous presence of ...
Elucidation of Carbohydrate Molecular Interaction Mechanism of Recombinant and Native ArtinM

Giménez Romero, David; Roberto Bueno, Paulo; Pesquero, Naira C.; Monzó, Isidro S.; Puchades, Rosa; Maquieira Catala, Ángel (American Chemical Society, 2013-07-18)

[EN] The quartz crystal microbalance (QCM) technique has been applied for monitoring the biorecognition of ArtinM lectins at low horseradish peroxidase glycoprotein (HRP) concentrations, using a simple kinetic model based ...
Excited state interactions between flurbiprofen and tryptophan in drug-protein complexes and in model dyads. Fluorescence studies from the femtosecond to the nanosecond time domains

Vayá Pérez, Ignacio; Bonancía Roca, Paula; Jiménez Molero, María Consuelo; Markovitsi, Dimitra; Gustavsson, Thomas; Miranda Alonso, Miguel Ángel (Royal Society of Chemistry, 2013)

We report here on the interaction dynamics between flurbiprofen (FBP) and tryptophan (Trp) covalently linked in model dyads and in a complex of FBP with human serum albumin (HSA) probed by time-resolved fluorescence ...
Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells

Soto-Cerrato, Vanessa; Manuel-Manresa, Pilar; Hernando, Elsa; Calabuig-Farinas, Silvia; Martinez-Romero, Alicia; Fernandez-Dueñas, Victor; Sahlholm, Kristoffer; Knoepfel, Thomas; Garcia-Valverde, Maria; Rodilla, Ananda M.; Jantus Lewintre, Eloisa; Farras, Rosa; Ciruela, Francisco; Perez-Tomas, Ricardo; Quesada, Roberto (American Chemical Society, 2015-12)

Facilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we ...
Living biointerfaces based on non-pathogenic bacteria to direct cell differentiation

Rodrigo Navarro, Aleixandre; Rico Tortosa, Patricia María; Saadeddin Saadeddin, Anas; Garcia, Andres J.; Salmerón Sánchez, Manuel (Nature Publishing Group, 2014-07-28)

Genetically modified Lactococcus lactis, non-pathogenic bacteria expressing the FNIII7-10 fibronectin fragment as a protein membrane have been used to create a living biointerface between synthetic materials and mammalian ...
Triplet excited state behavior of naphthalene-based pseudopeptides in the presence of energy donors

Bonancía Roca, Paula; Vigara, Laura; Galindo, Francisco; Luis, Santiago V.; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel (American Chemical Society, 2012-08-23)

In this work, the triplet state behavior of naphthalene-based pseudopeptides with amide-based macrocyclic or lateral chain substructures has been investigated in the presence of benzophenone and/or biphenyl, as suitable ...

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