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Mostrando ítems 1-2 de 2

Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials

Zemzemi, Nejib; Bernabeu, Miguel O.; Saiz Rodríguez, Francisco Javier; Cooper, Jonathan; Pathmanathan, Pras; Mirams, Gary R.; Pitt-Francis, Joe; Rodríguez, Blanca (Wiley-Blackwell, 2013-01)

BACKGROUND AND PURPOSE Understanding drug effects on the heart is key to safety pharmacology assessment and anti-arrhythmic therapy development. Here our goal is to demonstrate the ability of computational models to ...
Differential Modulation of I-K and I-Ca,I-L Channels in High-Fat Diet-Induced Obese Guinea Pig Atria

Martínez-Mateu, Laura; Saiz Rodríguez, Francisco Javier; Aromolaran, Ademuyiwa S. (Frontiers Media SA, 2019-09-25)

[EN] Obesity mechanisms that make atrial tissue vulnerable to arrhythmia are poorly understood. Voltage-dependent potassium (I-K, I-Kur, and I-K1) and L-type calcium currents (I-Ca,I- L) are electrically relevant and ...

Mostrando ítems 1-2 de 2