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Listar por palabra clave "Photosensitization"

Mostrando ítems 1-7 de 7

Alkylation of a hydrophilic photosensitizer enhances the contact-dependent photo-induced oxidation of phospholipid membranes

Vignoni, Alejandro; Layana, Carla; Junqueira, Helena C.; Thomas, Andrés H.; Itri, Rosangela; Baptista, Mauricio S.; Vignoni, Mariana (Elsevier, 2021-03)

[EN] Lipophilic photosensitizers able to photo-induce lipid oxidation in biomembranes are, in general, much more efficient than hydrophilic ones; acting through the formation of singlet oxygen (O-1(2)), which oxidizes the ...
Experimental and theoretical studies on thymine photodimerization mediated by oxidatively generated DNA lesions and epigenetic intermediates

Lineros-Rosa, Mauricio; Francés-Monerris, Antonio; Monari, Antonio; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria (The Royal Society of Chemistry, 2020-11-28)

[EN] Interaction of nucleic acids with light is a scientific question of paramount relevance not only in the understanding of life functioning and evolution, but also in the insurgence of diseases such as malignant skin ...
Fotorreparación de lesiones del ADN por sistemas modelo

Piñero Piquer, Enrique (Universitat Politècnica de València, 2022-07-18)

[ES] La peroxidación lipídica es un proceso biológico que ocurre ininterrumpidamenteen nuestro cuerpo como resultado de la oxidación de la membrana celular por especies reactivas de oxígeno (EROs). La degradación de los ...
Influence of the linking bridge on the photoreactivity of benzophenone-thymine conjugates

Blasco-Brusola, Alejandro; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel (American Chemical Society, 2020-11-06)

[EN] Benzophenone (BP) is present in a variety of bioactive molecules. This chromophore is able to photosensitize DNA damage, where one of the most relevant BP/ DNA interactions occurs with thymine (Thy). In view of the ...
Photochemical formation of a fluorescent thymidine-pterin adduct in DNA

Estébanez, Sandra; Lorente, Carolina; Gaspar Tosato, Maira; Miranda Alonso, Miguel Ángel; Marín García, Mª Luisa; Lhiaubet, Virginie Lyria; Thomas, Andrés H. (Elsevier, 2019-01)

[EN] The photochemistry of the DNA biomacromolecule is an issue of paramount importance as it is part of the etiology of skin cancer development, being ultraviolet sunlight radiation the most relevant environmental carcinogen. ...
Pterin-photosensitization of thymine under anaerobic conditions in the presence of guanine

Estébanez, Sandra; Rivera, Ana M.; Recky, Jael R. Neyra; Thomas, Andres H.; Lhiaubet, Virginie Lyria; Lorente, Carolina (Elsevier, 2021-10)

[EN] Pterin (Ptr) is a model photosensitizer that acts mainly through type I mechanism and is able to photoinduce the one-electron oxidation of purine and pyrimidine nucleobases. However, under anaerobic conditions Ptr ...
Singlet oxygen production and in vitro phototoxicity studies on fenofibrate, mycophenolate mofetil, trifusal, and their active metabolites

Molins-Molina, Oscar; Bresolí-Obach, Roger; García-Laínez, G.; Andreu Ros, María Inmaculada; Nonell, Santiago; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo (John Wiley & Sons, 2017-09)

[EN] Singlet oxygen photosensitization (studied by time-resolved near-infrared emission spectroscopy) and in vitro phototoxicity (by means of the 3T3 neutral red uptake assay) have been investigated for the prodrugs ...