- -

The MINDVIEW project: First results

RiuNet: Repositorio Institucional de la Universidad Politécnica de Valencia

Compartir/Enviar a

Citas

Estadísticas

  • Estadisticas de Uso

The MINDVIEW project: First results

Mostrar el registro sencillo del ítem

Ficheros en el ítem

Thumbnail
Nombre: Benlloch;González;Pani ...
Tamaño: 1.973Mb
Formato: PDF
Descripción: Versión del Autor.
Abrir
[Cerrado]
Nombre: Benlloch Eur Psy ...
Tamaño: 1.365Mb
Formato: PDF
Descripción: Versión editorial
Solicitar una copia al autor
dc.contributor.author Benlloch Baviera, Jose María es_ES
dc.contributor.author González Martínez, Antonio Javier es_ES
dc.contributor.author Pani, R. es_ES
dc.contributor.author Preziosi, Enrico es_ES
dc.contributor.author Jackson, C. es_ES
dc.contributor.author Murphy, J. es_ES
dc.contributor.author Barbera Ballester, Julio es_ES
dc.contributor.author Correcher Salvador, Carlos es_ES
dc.contributor.author Aussenhofer, Sebastian es_ES
dc.contributor.author Gareis, D. es_ES
dc.contributor.author Visvikis, Dimitris es_ES
dc.contributor.author Bert, J. es_ES
dc.contributor.author Langstrom, B. es_ES
dc.contributor.author Farde, Lars es_ES
dc.contributor.author Toth, M. es_ES
dc.contributor.author Haggkvist, J. es_ES
dc.contributor.author Caixeta, F. es_ES
dc.contributor.author Kullander, K. es_ES
dc.contributor.author Somlai-Schweiger, I. es_ES
dc.contributor.author Schwaiger, Markus es_ES
dc.date.accessioned 2020-06-17T03:38:55Z
dc.date.available 2020-06-17T03:38:55Z
dc.date.issued 2018-04 es_ES
dc.identifier.issn 0924-9338 es_ES
dc.identifier.uri http://hdl.handle.net/10251/146494
dc.description.abstract [EN] We present the first results of the MINDVIEW project. An innovative imaging system for the human brain examination, allowing simultaneous acquisition of PET/MRI images, has been designed and constructed. It consists of a high sensitivity and high resolution PET scanner integrated in a novel, head-dedicated, radio frequency coil for a 3T MRI scanner. Preliminary measurements from the PET scanner show sensitivity 3 times higher than state-of-the-art PET systems that will allow safe repeated studies on the same patient. The achieved spatial resolution, close to 1 mm, will enable differentiation of relevant brain structures for schizophrenia. A cost-effective and simple method of radiopharmaceutical production from C-11-carbon monoxide and a mini-clean room has been demonstrated. It has been shown that C-11-raclopride has higher binding potential in a new VAAT null mutant mouse model of schizophrenia compared to wild type control animals. A significant reduction in TSPO binding has been found in gray matter in a small sample of drug-naive, first episode psychosis patients, suggesting a reduced number or an altered function of immune cells in brain at early stage schizophrenia. (c) 2018 Elsevier Masson SAS. All rights reserved. es_ES
dc.description.sponsorship This project is funded by EU grant FP7-HEALTH-F2-2013-603002. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof European Psychiatry es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Schizophrenia es_ES
dc.subject Positron Emission Tomography es_ES
dc.subject Silicon photomultipliers and magnetic resonance es_ES
dc.title The MINDVIEW project: First results es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.eurpsy.2018.01.002 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603002/EU/Multimodal Imaging of Neurological Disorders/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular es_ES
dc.description.bibliographicCitation Benlloch Baviera, JM.; González Martínez, AJ.; Pani, R.; Preziosi, E.; Jackson, C.; Murphy, J.; Barbera Ballester, J.... (2018). The MINDVIEW project: First results. European Psychiatry. 50:21-27. https://doi.org/10.1016/j.eurpsy.2018.01.002 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.eurpsy.2018.01.002 es_ES
dc.description.upvformatpinicio 21 es_ES
dc.description.upvformatpfin 27 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 50 es_ES
dc.identifier.pmid 29398564 es_ES
dc.relation.pasarela S\406057 es_ES
dc.contributor.funder European Commission es_ES
dc.description.references Gonzalez, A. J., Gonzalez-Montoro, A., Aguilar, A., Conde, P., Canizares, G., Hernandez, L., … Benlloch, J. M. (2016). A brain PET insert MR compatible: Final design and first results. 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop (NSS/MIC/RTSD). doi:10.1109/nssmic.2016.8069619 es_ES
dc.description.references Dahl, K., Schou, M., Ulin, J., Sjöberg, C.-O., Farde, L., & Halldin, C. (2015). 11C-carbonylation reactions using gas–liquid segmented microfluidics. RSC Advances, 5(108), 88886-88889. doi:10.1039/c5ra20646d es_ES
dc.description.references [26] Långström B and Sjöberg CO, System for controlling environment in reaction box, From PCT Int. Appl. (2013), WO 2013103312 A1 20130711. es_ES
dc.description.references Autret, A., Bert, J., Strauss, O., & Visvikis, D. (2012). Projector with realistic detector scatter modelling for PET list-mode reconstruction. 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC). doi:10.1109/nssmic.2012.6551759 es_ES
dc.description.references [10] Young JW Head and Face Antropometry of Adult U.S. Citizens, Civil Aeromedical Institute, Federal Aviation Administration, U.S. Department of Transportation, Report number DOT/FAA/AM-93/10, July 1993. es_ES
dc.description.references Braff, D. L. (1990). Sensorimotor Gating and Schizophrenia. Archives of General Psychiatry, 47(2), 181. doi:10.1001/archpsyc.1990.01810140081011 es_ES
dc.description.references Preziosi, E., Sánchez, S., González, A. J., Pani, R., Borrazzo, C., Bettiol, M., … Benlloch, J. M. (2016). Performance study of a PET scanner based on monolithic scintillators for different DoI-dependent methods. Journal of Instrumentation, 11(12), C12076-C12076. doi:10.1088/1748-0221/11/12/c12076 es_ES
dc.description.references Howes, O., McCutcheon, R., & Stone, J. (2015). Glutamate and dopamine in schizophrenia: An update for the 21st century. Journal of Psychopharmacology, 29(2), 97-115. doi:10.1177/0269881114563634 es_ES
dc.description.references Moliner, L., Correcher, C., González, A. J., Conde, P., Hernández, L., Orero, A., … Benlloch, J. M. (2013). Implementation and analysis of list mode algorithm using tubes of response on a dedicated brain and breast PET. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 702, 129-132. doi:10.1016/j.nima.2012.08.029 es_ES
dc.description.references Zelano, J., Mikulovic, S., Patra, K., Kühnemund, M., Larhammar, M., Emilsson, L., … Kullander, K. (2013). The synaptic protein encoded by the gene Slc10A4 suppresses epileptiform activity and regulates sensitivity to cholinergic chemoconvulsants. Experimental Neurology, 239, 73-81. doi:10.1016/j.expneurol.2012.09.006 es_ES
dc.description.references Antich, P., Malakhov, N., Parkey, R., Slavin, N., & Tsyganov, E. (2002). 3D position readout from thick scintillators. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 480(2-3), 782-787. doi:10.1016/s0168-9002(01)01214-1 es_ES
dc.description.references Gonzalez-Montoro, A., Benlloch, J. M., Gonzalez, A. J., Aguilar, A., Canizares, G., Conde, P., … Sanchez, F. (2017). Performance Study of a Large Monolithic LYSO PET Detector With Accurate Photon DOI Using Retroreflector Layers. IEEE Transactions on Radiation and Plasma Medical Sciences, 1(3), 229-237. doi:10.1109/trpms.2017.2692819 es_ES
dc.description.references Rahman, O., Takano, A., Amini, N., Dahl, K., Kanegawa, N., Långström, B., … Halldin, C. (2015). Synthesis of ([11C]carbonyl)raclopride and a comparison with ([11C]methyl)raclopride in a monkey PET study. Nuclear Medicine and Biology, 42(11), 893-898. doi:10.1016/j.nucmedbio.2015.07.003 es_ES
dc.description.references Howes, O. D., Kambeitz, J., Kim, E., Stahl, D., Slifstein, M., Abi-Dargham, A., & Kapur, S. (2012). The Nature of Dopamine Dysfunction in Schizophrenia and What This Means for Treatment. Archives of General Psychiatry, 69(8). doi:10.1001/archgenpsychiatry.2012.169 es_ES
dc.description.references Ling, T., Lewellen, T. K., & Miyaoka, R. S. (2007). Depth of interaction decoding of a continuous crystal detector module. Physics in Medicine and Biology, 52(8), 2213-2228. doi:10.1088/0031-9155/52/8/012 es_ES
dc.description.references González, A. J., Majewski, S., Sánchez, F., Aussenhofer, S., Aguilar, A., Conde, P., … Benlloch, J. M. (2016). The MINDView brain PET detector, feasibility study based on SiPM arrays. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 818, 82-90. doi:10.1016/j.nima.2016.02.046 es_ES
dc.description.references Wong, D. F., Waterhouse, R., Kuwabara, H., Kim, J., Brasic, J. R., Chamroonrat, W., … Mozley, P. D. (2013). 18F-FPEB, a PET Radiopharmaceutical for Quantifying Metabotropic Glutamate 5 Receptors: A First-in-Human Study of Radiochemical Safety, Biokinetics, and Radiation Dosimetry. Journal of Nuclear Medicine, 54(3), 388-396. doi:10.2967/jnumed.112.107995 es_ES
dc.description.references Jackson, C., O’Neill, K., Wall, L., & McGarvey, B. (2014). High-volume silicon photomultiplier production, performance, and reliability. Optical Engineering, 53(8), 081909. doi:10.1117/1.oe.53.8.081909 es_ES
dc.description.references Rahman, O., Långström, B., & Halldin, C. (2016). Alkyl Iodides and [11 C]CO in Nickel-Mediated Cross-Coupling Reactions: Successful Use of Alkyl Electrophiles containing a β Hydrogen Atom in Metal-Mediated [11 C]Carbonylation. ChemistrySelect, 1(10), 2498-2501. doi:10.1002/slct.201600643 es_ES
dc.description.references Sullivan, J. M., Lim, K., Labaree, D., Lin, S., McCarthy, T. J., Seibyl, J. P., … Morris, E. D. (2012). Kinetic Analysis of the Metabotropic Glutamate Subtype 5 Tracer [18F]FPEB in Bolus and Bolus-Plus-Constant-Infusion Studies in Humans. Journal of Cerebral Blood Flow & Metabolism, 33(4), 532-541. doi:10.1038/jcbfm.2012.195 es_ES
dc.description.references Levin, C. S. (2003). Detector design issues for compact nuclear emission cameras dedicated to breast imaging. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 497(1), 60-74. doi:10.1016/s0168-9002(02)01893-4 es_ES
dc.description.references Larhammar, M., Patra, K., Blunder, M., Emilsson, L., Peuckert, C., Arvidsson, E., … Kullander, K. (2015). SLC10A4 Is a Vesicular Amine-Associated Transporter Modulating Dopamine Homeostasis. Biological Psychiatry, 77(6), 526-536. doi:10.1016/j.biopsych.2014.07.017 es_ES
dc.description.references Kaul, M., Surti, S., & Karp, J. S. (2013). Combining Surface Treatments With Shallow Slots to Improve the Spatial Resolution Performance of Continuous, Thick LYSO Detectors for PET. IEEE Transactions on Nuclear Science, 60(1), 44-52. doi:10.1109/tns.2013.2240315 es_ES
dc.description.references Bleich, A., Brown, S.-L., Kahn, R., & van Praag, H. M. (1988). The Role of Serotonin in Schizophrenia. Schizophrenia Bulletin, 14(2), 297-315. doi:10.1093/schbul/14.2.297 es_ES


Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem