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Genome Mutational and Transcriptional Hotspots Are Traps for Duplicated Genes and Sources of Adaptations

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Genome Mutational and Transcriptional Hotspots Are Traps for Duplicated Genes and Sources of Adaptations

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dc.contributor.author Fares Riaño, Mario Ali es_ES
dc.contributor.author Sabater-Muñoz, B. es_ES
dc.contributor.author Toft, C. es_ES
dc.date.accessioned 2020-09-12T03:35:17Z
dc.date.available 2020-09-12T03:35:17Z
dc.date.issued 2017-05-01 es_ES
dc.identifier.issn 1759-6653 es_ES
dc.identifier.uri http://hdl.handle.net/10251/149960
dc.description.abstract [EN] Gene duplication generates new genetic material, which has been shown to lead to major innovations in unicellular and multicellular organisms. A whole-genome duplication occurred in the ancestor of Saccharomyces yeast species but 92% of duplicates returned to single-copy genes shortly after duplication. The persisting duplicated genes in Saccharomyces led to the origin of major metabolic innovations, which have been the source of the unique biotechnological capabilities in the Baker's yeast Saccharomyces cerevisiae. What factors have determined the fate of duplicated genes remains unknown. Here, we report the first demonstration that the local genome mutation and transcription rates determine the fate of duplicates. We show, for the first time, a preferential location of duplicated genes in the mutational and transcriptional hotspots of S. cerevisiae genome. The mechanism of duplication matters, with whole-genome duplicates exhibiting different preservation trends compared to small-scale duplicates. Genome mutational and transcriptional hotspots are rich in duplicates with large repetitive promoter elements. Saccharomyces cerevisiae shows more tolerance to deleterious mutations in duplicates with repetitive promoter elements, which in turn exhibit higher transcriptional plasticity against environmental perturbations. Our data demonstrate that the genome traps duplicates through the accelerated regulatory and functional divergence of their gene copies providing a source of novel adaptations in yeast. es_ES
dc.description.sponsorship This study was supported by a grant (reference: FEDER-BFU2015-66073-P) from the Spanish Ministerio de Economia y Competitividad-FEDER and a grant (reference: ACOMP/2015/026) from the local government Conselleria de Educacion Investigacion, Cultura y Deporte, Generalitat Valenciana to M.A.F. C.T. was supported by a grant Juan de la Cierva from the Spanish Ministerio de Economia y Competitividad (reference: JCA-2012-14056). es_ES
dc.language Inglés es_ES
dc.publisher Oxford University Press es_ES
dc.relation.ispartof Genome Biology and Evolution es_ES
dc.rights Reconocimiento - No comercial (by-nc) es_ES
dc.subject Gene duplication es_ES
dc.subject Mutational genome hotspots es_ES
dc.subject Expression genome hotspots es_ES
dc.subject Environmental stress es_ES
dc.subject Phenotypic plasticity es_ES
dc.subject Adaptations es_ES
dc.subject Genetic redundancy es_ES
dc.title Genome Mutational and Transcriptional Hotspots Are Traps for Duplicated Genes and Sources of Adaptations es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1093/gbe/evx085 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BFU2015-66073-P/ES/CARACTERIZANDO LOS MECANISMOS DE INNOVACION POR DUPLICACION GENICA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//ACOMP%2F2015%2F026/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//JCI-2012-14056/ES/JCI-2012-14056/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Fares Riaño, MA.; Sabater-Muñoz, B.; Toft, C. (2017). Genome Mutational and Transcriptional Hotspots Are Traps for Duplicated Genes and Sources of Adaptations. Genome Biology and Evolution. 9(5):1229-1240. https://doi.org/10.1093/gbe/evx085 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1093/gbe/evx085 es_ES
dc.description.upvformatpinicio 1229 es_ES
dc.description.upvformatpfin 1240 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 9 es_ES
dc.description.issue 5 es_ES
dc.identifier.pmid 28459980 es_ES
dc.identifier.pmcid PMC5433386 es_ES
dc.relation.pasarela S\356158 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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