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Link-Level Functional Connectivity Neuroalterations in Autism Spectrum Disorder: A Developmental Resting-State fMRI Study

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Link-Level Functional Connectivity Neuroalterations in Autism Spectrum Disorder: A Developmental Resting-State fMRI Study

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dc.contributor.author Borràs-Ferrís, Lluis es_ES
dc.contributor.author Pérez-Ramírez, María Úrsula es_ES
dc.contributor.author Moratal, David es_ES
dc.date.accessioned 2020-11-25T04:31:33Z
dc.date.available 2020-11-25T04:31:33Z
dc.date.issued 2019-03-21 es_ES
dc.identifier.uri http://hdl.handle.net/10251/155701
dc.description.abstract [EN] Autism spectrum disorder (ASD) is a neurological and developmental disorder whose late diagnosis is based on subjective tests. In seeking for earlier diagnosis, we aimed to find objective biomarkers via analysis of resting-state functional MRI (rs-fMRI) images obtained from the Autism Brain Image Data Exchange (ABIDE) database. Thus, we estimated brain functional connectivity (FC) between pairs of regions as the statistical dependence between their neural-related blood-oxygen-level-dependent (BOLD) signals. We compared FC of individuals with ASD and healthy controls, matched by age and intelligence quotient (IQ), and split into three age groups (50 children, 98 adolescents, and 32 adults), from a developmental perspective. After estimating the correlation, we observed hypoconnectivities in children and adolescents with ASD between regions belonging to the default mode network (DMN). Concretely, in children, FC decreased between the left middle temporal gyrus and right frontal pole (p = 0.0080), and between the left orbitofrontal cortex and right superior frontal gyrus (p = 0.0144). In adolescents, this decrease was observed between bilateral postcentral gyri (p = 0.0012), and between the right precuneus and right middle temporal gyrus (p = 0.0236). These results help to gain a better understanding of the involved regions on autism and its connection with the affected superior cognitive brain functions. es_ES
dc.description.sponsorship This research was partially funded by the Ministerio de Economia y Competitividad (MINECO), through the project BFU2015-64380-C2-2-R. U.P.-R. is funded by the Spanish Ministerio de Educacion, Cultura y Deporte (MECD) under grant FPU13/03537. We are thankful to the initiative ABIDE to provide the huge public release and open sharing autism database what has made possible to carry out this study in better conditions and improve the results obtained significantly. es_ES
dc.language Inglés es_ES
dc.publisher MDPI AG es_ES
dc.relation.ispartof Diagnostics es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Autism es_ES
dc.subject Brain functional connectivity es_ES
dc.subject Default mode network es_ES
dc.subject Full correlation analysis es_ES
dc.subject Partial correlation analysis es_ES
dc.subject Region of interest analysis es_ES
dc.subject Resting-state functional MRI es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Link-Level Functional Connectivity Neuroalterations in Autism Spectrum Disorder: A Developmental Resting-State fMRI Study es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/diagnostics9010032 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MECD//FPU13%2F03537/ES/FPU13%2F03537/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BFU2015-64380-C2-2-R/ES/ANALISIS DE TEXTURAS EN IMAGEN CEREBRAL MULTIMODAL POR RESONANCIA MAGNETICA PARA UNA DETECCION TEMPRANA DE ALTERACIONES EN LA RED Y BIOMARCADORES DE ENFERMEDAD/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Borràs-Ferrís, L.; Pérez-Ramírez, MÚ.; Moratal, D. (2019). Link-Level Functional Connectivity Neuroalterations in Autism Spectrum Disorder: A Developmental Resting-State fMRI Study. Diagnostics. 9(1):1-10. https://doi.org/10.3390/diagnostics9010032 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3390/diagnostics9010032 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 10 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 9 es_ES
dc.description.issue 1 es_ES
dc.identifier.eissn 2075-4418 es_ES
dc.identifier.pmid 30901848 es_ES
dc.identifier.pmcid PMC6468479 es_ES
dc.relation.pasarela S\405763 es_ES
dc.contributor.funder Ministerio de Educación es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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