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Selective synthesis of citrus flavonoids prunin and naringenin using heterogeneized biocatalyst on graphene oxide

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Selective synthesis of citrus flavonoids prunin and naringenin using heterogeneized biocatalyst on graphene oxide

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dc.contributor.author Carceller-Carceller, Jose Miguel es_ES
dc.contributor.author Martínez Galán, Julián Paul es_ES
dc.contributor.author Monti, Rubens es_ES
dc.contributor.author Bassan, Juliana Cristina es_ES
dc.contributor.author Filice, Marco es_ES
dc.contributor.author Iborra Chornet, Sara es_ES
dc.contributor.author Yu, Jihong es_ES
dc.contributor.author Corma Canós, Avelino es_ES
dc.date.accessioned 2020-12-11T04:34:24Z
dc.date.available 2020-12-11T04:34:24Z
dc.date.issued 2019-02-21 es_ES
dc.identifier.issn 1463-9262 es_ES
dc.identifier.uri http://hdl.handle.net/10251/156865
dc.description.abstract [EN] Production of citrus flavonoids prunin and naringenin was performed selectively through the enzyme hydrolysis of naringin, a flavonoid glycoside abundant in grapefruit wastes. To produce the monoglycoside flavonoid, prunin, crude naringinase from Penicillium decumbens was purified by a single purification step resulting in an enzyme with high -rhamnosidase activity. Both crude and purified enzymes were covalently immobilized on graphene oxide. The activity of the immobilized enzymes at different pH levels and temperatures, and the thermal stability were determined and compared with those exhibited by the free naringinases using specific substrates: p-nitrophenyl--d-glucoside (Glc-pNP) and p-nitrophenyl-alpha-l-rhamnopyranoside (Rha-pNP). The crude and purified naringinase supported on GO were tested in the hydrolysis of naringin, giving naringenin and prunin, respectively, in excellent yields. The supported enzymes can be reused many times without loss of activity. The naringinase stabilized on GO has high potential to produce the valuable citrus flavonoids prunin and naringenin. es_ES
dc.description.sponsorship Authors acknowledge the financial support from MICINN Project CTQ-2015-67592-P and Program Severo Ochoa (SEV-2016-0683). JVC thanks Universitat Politecnica de Valencia for predoctoral fellowships. JY and AC thank the support from the National Natural Science Foundation of China (Grant No. 21320102001) and the 111 Project (Grant No. B17020). es_ES
dc.language Inglés es_ES
dc.publisher The Royal Society of Chemistry es_ES
dc.relation.ispartof Green Chemistry es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Selective synthesis of citrus flavonoids prunin and naringenin using heterogeneized biocatalyst on graphene oxide es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/c8gc03661f es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//SEV-2016-0683/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NSFC//21320102001/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MOE//B17020/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CTQ2015-67592-P/ES/VALORIZACION DE COMPUESTO OXIGENADOS PRESENTES EN FRACCIONES ACUOSAS DERIVADAS DE BIOMASA EN COMBUSTIBLES Y PRODUCTOS QUIMICOS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-097277-B-I00/ES/MEJORA DEL CONCEPTO DE BIORREFINERIA MEDIANTE IMPLEMENTACION DE NUEVOS PROCESOS CATALITICOS CON CATALIZADORES SOLIDOS DE METALES NO NOBLES PARA LA PRODUCCION DE BIOCOMPUESTOS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Carceller-Carceller, JM.; Martínez Galán, JP.; Monti, R.; Bassan, JC.; Filice, M.; Iborra Chornet, S.; Yu, J.... (2019). Selective synthesis of citrus flavonoids prunin and naringenin using heterogeneized biocatalyst on graphene oxide. Green Chemistry. 21(4):839-849. https://doi.org/10.1039/c8gc03661f es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1039/c8gc03661f es_ES
dc.description.upvformatpinicio 839 es_ES
dc.description.upvformatpfin 849 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 21 es_ES
dc.description.issue 4 es_ES
dc.relation.pasarela S\382572 es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder National Natural Science Foundation of China es_ES
dc.contributor.funder Ministry of Education, China es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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