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dc.contributor.author | Añón, Elena | es_ES |
dc.contributor.author | Costero, Ana M. | es_ES |
dc.contributor.author | Amorós del Toro, Pedro | es_ES |
dc.contributor.author | El Haskouri, Jamal | es_ES |
dc.contributor.author | Martínez-Máñez, Ramón | es_ES |
dc.contributor.author | Parra Álvarez, Margarita | es_ES |
dc.contributor.author | Gil Grau, Salvador | es_ES |
dc.contributor.author | Gaviña, Pablo | es_ES |
dc.contributor.author | Terencio Silvestre, María Carmen | es_ES |
dc.contributor.author | Alfonso-Navarro, María | es_ES |
dc.date.accessioned | 2021-01-14T04:32:55Z | |
dc.date.available | 2021-01-14T04:32:55Z | |
dc.date.issued | 2020-03-31 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/158947 | |
dc.description | This is the peer reviewed version of the following article: E. Añón, A. M. Costero, P. Amorós, J. El Haskouri, R. Martínez-Mánez, M. Parra, S. Gil, P. Gaviña, M. C. Terencio, M. Alfonso, ChemistrySelect 2020, 5, 3618., which has been published in final form at https://doi.org/10.1002/slct.202000417. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |
dc.description.abstract | [EN] Osteoporosis is an illness which appears when the osteoblast/osteoclast activities are unbalanced taking place bone resorption (caused by osteoclasts) in higher extension than bone formation (induced by osteoblasts). Alendronate is one of the most used drugs for osteoporosis treatment despite its scarce bioavailability. Here we present the synthesis and characterization of mesoporous gated nanoparticles (two sets) for the controlled release of alendronate. The first set of nanoparticles (S1) were loaded with sulforhodamine B and capped with a peptide that could be selectively hydrolyzed by cathepsin K enzyme (overexpressed in osteoclasts). The second set (S2) was functionalized with aminopropyl moieties, loaded with nitrobenzofurazan labelled alendronate and capped with the same peptide. Both nanoparticles were internalized by RAW 264.7 macrophages (which could differentiate in osteoclasts) and were able to release its entrapped cargo in the presence of cathepsin K added in the macrophage lysates. Using S2 nanoparticles 4.2% of the total alendronate amount in contact with the cells is liberated inside them and could produce its therapeutic effect. | es_ES |
dc.description.sponsorship | We thank the Spanish Government (RTI2018-100910-B-C41, RTI2018-100910-B-C42 (MCUI/AEI/FEDER, UE)) and the Generalitat Valenciana (PROMETEU/2018/024) for support. SCSIE (Universitat de Valencia) is gratefully acknowledged for all the equipment employed. NMR was registered at the U26 facility of ICTS "NANBIOSIS" at the Universitat of Valencia. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.relation.ispartof | ChemistrySelect | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Alendronate | es_ES |
dc.subject | Enzymes | es_ES |
dc.subject | Cathepsin K | es_ES |
dc.subject | Nanoparticles | es_ES |
dc.subject | Osteoporosis | es_ES |
dc.subject.classification | QUIMICA INORGANICA | es_ES |
dc.subject.classification | QUIMICA ORGANICA | es_ES |
dc.title | Peptide-Capped Mesoporous Nanoparticles: Toward a more Efficient Internalization of Alendronate | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1002/slct.202000417 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-100910-B-C42/ES/MATERIALES INTELIGENTES PARA LA DETECCION DE DROGAS DE ABUSO Y BIOMARCADORES/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEO%2F2018%2F024/ES/Sistemas avanzados de liberación controlada/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-100910-B-C41/ES/MATERIALES POROSOS INTELIGENTES MULTIFUNCIONALES Y DISPOSITIVOS ELECTRONICOS PARA LA LIBERACION DE FARMACOS, DETECCION DE DROGAS Y BIOMARCADORES Y COMUNICACION A NANOESCALA/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Química - Departament de Química | es_ES |
dc.description.bibliographicCitation | Añón, E.; Costero, AM.; Amorós Del Toro, P.; El Haskouri, J.; Martínez-Máñez, R.; Parra Álvarez, M.; Gil Grau, S.... (2020). Peptide-Capped Mesoporous Nanoparticles: Toward a more Efficient Internalization of Alendronate. ChemistrySelect. 5(12):3618-3625. https://doi.org/10.1002/slct.202000417 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1002/slct.202000417 | es_ES |
dc.description.upvformatpinicio | 3618 | es_ES |
dc.description.upvformatpfin | 3625 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 5 | es_ES |
dc.description.issue | 12 | es_ES |
dc.identifier.eissn | 2365-6549 | es_ES |
dc.relation.pasarela | S\418264 | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
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