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Folate Metabolism Interferes with Plant Immunity through 1C Methionine Synthase-Directed Genome-wide DNA Methylation Enhancement

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Folate Metabolism Interferes with Plant Immunity through 1C Methionine Synthase-Directed Genome-wide DNA Methylation Enhancement

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dc.contributor.author González, Beatriz es_ES
dc.contributor.author Vera Vera, Pablo es_ES
dc.date.accessioned 2021-01-21T04:31:51Z
dc.date.available 2021-01-21T04:31:51Z
dc.date.issued 2019-09-02 es_ES
dc.identifier.issn 1674-2052 es_ES
dc.identifier.uri http://hdl.handle.net/10251/159603
dc.description.abstract [EN] Plants rely on primary metabolism for flexible adaptation to environmental changes. Here, through a combination of chemical genetics and forward genetic studies in Arabidopsis plants, we identified that the essential folate metabolic pathway exerts a salicylic acid-independent negative control on plant immunity. Disruption of the folate pathway promotes enhanced resistance to Pseudomonas syringae DC3000 via activation of a primed immune state in plants, whereas its implementation results in enhanced susceptibility. Comparative proteomics analysis using immune-defective mutants identified a methionine synthase (METS1), in charge of the synthesis of Met through the folate-dependent 1C metabolism, acting as a nexus between the folate pathway and plant immunity. Overexpression of METS1 represses plant immunity and is accompanied by genome-wide global increase in DNA methylation, revealing that imposing a methylation pressure at the genomic level compromises plant immunity. Take together, these results indicate that the folate pathway represents a new layer of complexity in the regulation of plant defense responses. es_ES
dc.description.sponsorship We acknowledge V. Flors for the determination of SA level, S. Tarraga for the 2D-DIGE analysis and selection of spots proteins, and the SCSIE_University of Valencia Proteomics Unit for MS-MALDI-TOF/TOF and/or LC-MS/MS analyses. We thank J. Forment for his assistance with the analysis of methylation data from the ZR platform, and J. Garcia-Andrade, V. Ramirez, and L. Castelblanque for critical discussions. No conflict of interest declared. We acknowledge the Spanish Ministerio de Ciencia, Innovacion y Universidades (MICIU) for grants BFU2015-68199-R RTI2018-098501-B-100 to P.V. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Molecular Plant es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Folate pathway es_ES
dc.subject Plant immunity es_ES
dc.subject Methionine es_ES
dc.subject DNA methylation es_ES
dc.subject.classification BIOQUIMICA Y BIOLOGIA MOLECULAR es_ES
dc.title Folate Metabolism Interferes with Plant Immunity through 1C Methionine Synthase-Directed Genome-wide DNA Methylation Enhancement es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.molp.2019.04.013 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BFU2015-68199-R /ES/SOBRE LOS MECANISMOS DE SUSCEPTIBILIDAD A PATOGENOS EN ARABIDOPSIS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-098501-B-I00/ES/NUEVOS MEDIADORES DE LA ACTIVACION DE MECANISMOS DE RESISTENCIA Y DE FACTORES SUSCEPTIBILIDAD DE LA PLANTA A MICROORGANISMOS PATOGENOS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation González, B.; Vera Vera, P. (2019). Folate Metabolism Interferes with Plant Immunity through 1C Methionine Synthase-Directed Genome-wide DNA Methylation Enhancement. Molecular Plant. 12(9):1227-1242. https://doi.org/10.1016/j.molp.2019.04.013 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.molp.2019.04.013 es_ES
dc.description.upvformatpinicio 1227 es_ES
dc.description.upvformatpfin 1242 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 12 es_ES
dc.description.issue 9 es_ES
dc.identifier.pmid 31077872 es_ES
dc.relation.pasarela S\406813 es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
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