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Characterization of a preclinical PET insert in a 7 tesla MRI scanner: beyond NEMA testing

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Characterization of a preclinical PET insert in a 7 tesla MRI scanner: beyond NEMA testing

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dc.contributor.author Gsell, Willy es_ES
dc.contributor.author Molinos, Cesar es_ES
dc.contributor.author Correcher, Carlos es_ES
dc.contributor.author Belderbos, Sarah es_ES
dc.contributor.author Wouters, Jens es_ES
dc.contributor.author Junge, Sven es_ES
dc.contributor.author Heidenreich, Michael es_ES
dc.contributor.author Vande Velde, Greetje es_ES
dc.contributor.author Rezaei, Ahmadreza es_ES
dc.contributor.author Nuyts, Johan es_ES
dc.contributor.author Cawthorne, Christopher es_ES
dc.contributor.author Cleeren, Frederik es_ES
dc.contributor.author Nannan, Lise es_ES
dc.contributor.author Deroose, Christophe M. es_ES
dc.contributor.author Himmelreich, Uwe es_ES
dc.contributor.author González Martínez, Antonio Javier es_ES
dc.date.accessioned 2021-05-27T03:33:16Z
dc.date.available 2021-05-27T03:33:16Z
dc.date.issued 2020-12-21 es_ES
dc.identifier.issn 0031-9155 es_ES
dc.identifier.uri http://hdl.handle.net/10251/166819
dc.description.abstract [EN] This study evaluates the performance of the Bruker positron emission tomograph (PET) insert combined with a BioSpec 70/30 USR magnetic resonance imaging (MRI) scanner using the manufacturer acceptance protocol and the NEMA NU 4-2008 for small animal PET. The PET insert is made of 3 rings of 8 monolithic LYSO crystals (50 x 50 x 10 mm(3)) coupled to silicon photomultipliers (SiPM) arrays, conferring an axial and transaxial FOV of 15 cm and 8 cm. The MRI performance was evaluated with and without the insert for the following radiofrequency noise, magnetic field homogeneity and image quality. For the PET performance, we extended the NEMA protocol featuring system sensitivity, count rates, spatial resolution and image quality to homogeneity and accuracy for quantification using several MRI sequences (RARE, FLASH, EPI and UTE). The PET insert does not show any adverse effect on the MRI performances. The MR field homogeneity is well preserved (Diameter Spherical Volume, for 20 mm of 1.98 +/- 4.78 without and -0.96 +/- 5.16 Hz with the PET insert). The PET insert has no major effect on the radiofrequency field. The signal-to-noise ratio measurements also do not show major differences. Image ghosting is well within the manufacturer specifications (<2.5%) and no RF noise is visible. Maximum sensitivity of the PET insert is 11.0% at the center of the FOV even with simultaneous acquisition of EPI and RARE. PET MLEM resolution is 0.87 mm (FWHM) at 5 mm off-center of the FOV and 0.97 mm at 25 mm radial offset. The peaks for true/noise equivalent count rates are 410/240 and 628/486 kcps for the rat and mouse phantoms, and are reached at 30.34/22.85 and 27.94/22.58 MBq. PET image quality is minimally altered by the different MRI sequences. The Bruker PET insert shows no adverse effect on the MRI performance and demonstrated a high sensitivity, sub-millimeter resolution and good image quality even during simultaneous MRI acquisition. es_ES
dc.description.sponsorship We acknowledge the KU Leuven core facility, Molecular Small Animal Imaging Center (MoSAIC), for their support with obtaining scientific data presented in this paper. This work was supported by Stichting tegen Kanker (2015-145, Christophe M. Deroose) and Hercules foundation (AKUL/13/029, Uwe Himmelreich) for the purchase of the PET and MRI equipment respectively. The work was supported by the following funding organizations: European Commission for the PANA project (H2020-NMP-2015-two-stage, grant 686009) and the European ERA-NET project 'CryptoView' (3rd call of the FP7 program Infect-ERA). es_ES
dc.language Inglés es_ES
dc.publisher IOP Publishing es_ES
dc.relation.ispartof Physics in Medicine and Biology es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Preclinical es_ES
dc.subject PET-insert es_ES
dc.subject MRI es_ES
dc.subject Performances es_ES
dc.subject Imaging es_ES
dc.title Characterization of a preclinical PET insert in a 7 tesla MRI scanner: beyond NEMA testing es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1088/1361-6560/aba08c es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/321529/EU/Coordination of European funding for infectious diseases research/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Stichting Tegen Kanker//2015-145/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/686009/EU/PROMOTING ACTIVE AGEING: FUNCTIONAL NANOSTRUCTURES FOR ALZHEIMER’S DISEASE AT ULTRA-EARLY STAGES./ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Hercules Foundation//AKUL%2F13%2F029/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular es_ES
dc.description.bibliographicCitation Gsell, W.; Molinos, C.; Correcher, C.; Belderbos, S.; Wouters, J.; Junge, S.; Heidenreich, M.... (2020). Characterization of a preclinical PET insert in a 7 tesla MRI scanner: beyond NEMA testing. Physics in Medicine and Biology. 65(24):1-16. https://doi.org/10.1088/1361-6560/aba08c es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1088/1361-6560/aba08c es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 16 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 65 es_ES
dc.description.issue 24 es_ES
dc.identifier.pmid 32590380 es_ES
dc.relation.pasarela S\431263 es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Hercules Foundation es_ES
dc.contributor.funder Stichting Tegen Kanker es_ES
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