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Influence of glucometric 'dynamical' variables on Duodenal-Jejunal Bypass Liner (DJBL) anthropometric and metabolic outcomes

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Influence of glucometric 'dynamical' variables on Duodenal-Jejunal Bypass Liner (DJBL) anthropometric and metabolic outcomes

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dc.contributor.author Colás, Ana es_ES
dc.contributor.author Varela, Manuel es_ES
dc.contributor.author Mraz, Milos es_ES
dc.contributor.author Novak, Daniel es_ES
dc.contributor.author Cuesta Frau, David es_ES
dc.contributor.author Vigil, Luis es_ES
dc.contributor.author Benes, Marek es_ES
dc.contributor.author Pelikanova, Terezie es_ES
dc.contributor.author Haluzik, Martin es_ES
dc.contributor.author Burda, Vaclav es_ES
dc.contributor.author Vargas, Borja es_ES
dc.date.accessioned 2021-06-12T03:33:49Z
dc.date.available 2021-06-12T03:33:49Z
dc.date.issued 2020-05 es_ES
dc.identifier.issn 1520-7552 es_ES
dc.identifier.uri http://hdl.handle.net/10251/167868
dc.description.abstract [EN] Background The endoscopically implanted duodenal-jejunal bypass liner (DJBL) is an attractive alternative to bariatric surgery for obese diabetic patients. This article aims to study dynamical aspects of the glycaemic profile that may influence DJBL effects. Methods Thirty patients underwent DJBL implantation and were followed for 10 months. Continuous glucose monitoring (CGM) was performed before implantation and at month 10. Dynamical variables from CGM were measured: coefficient of variation of glycaemia, mean amplitude of glycaemic excursions (MAGE), detrended fluctuation analysis (DFA), % of time with glycaemia under 6.1 mmol/L (TU6.1), area over 7.8 mmol/L (AO7.8) and time in range. We analysed the correlation between changes in both anthropometric (body mass index, BMI and waist circumference) and metabolic (fasting blood glucose, FBG and HbA1c) variables and dynamical CGM-derived metrics and searched for variables in the basal CGM that could predict successful outcomes. Results There was a poor correlation between anthropometric and metabolic outcomes. There was a strong correlation between anthropometric changes and changes in glycaemic tonic control ( increment BMI- increment TU6.1: rho = - 0.67, P < .01) and between metabolic outcomes and glycaemic phasic control ( increment FBG- increment AO7.8: r = .60, P < .01). Basal AO7.8 was a powerful predictor of successful metabolic outcome (0.85 in patients with AO7.8 above the median vs 0.31 in patients with AO7.8 below the median: Chi-squared = 5.67, P = .02). Conclusions In our population, anthropometric outcomes of DJBL correlate with improvement in tonic control of glycaemia, while metabolic outcomes correlate preferentially with improvement in phasic control. Assessment of basal phasic control may help in candidate profiling for DJBL implantation. es_ES
dc.description.sponsorship Research Center for Informatics, Grant/Award Number: CZ.02.1.01/0.0/0.0/16_019/0000765; Biomedical data acquisition, processing and visualization, Grant/Award Number: SGS19/171/OHK3/3T/13; MH CZ - DRO ("IKEM, IN 00023001"); RVO VFN64165 es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation.ispartof Diabetes/Metabolism Research and Reviews es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Diabesity es_ES
dc.subject Type 2 diabetes mellitus es_ES
dc.subject Continuous glucose monitoring es_ES
dc.subject Duodenal-jejunal bypass liner (DJBL) es_ES
dc.subject Metabolic surgery es_ES
dc.subject Detrended fluctuation analysis (DFA) es_ES
dc.subject.classification ARQUITECTURA Y TECNOLOGIA DE COMPUTADORES es_ES
dc.title Influence of glucometric 'dynamical' variables on Duodenal-Jejunal Bypass Liner (DJBL) anthropometric and metabolic outcomes es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/dmrr.3287 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CVUT//CZ.02.1.01%2F0.0%2F0.0%2F16-019%2F0000765/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MZCR//DRO IKEM 000023001/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MZCR//RVO VFN 64165/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CVUT//SGS19%2F171%2FOHK3%2F3T%2F13/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Informática de Sistemas y Computadores - Departament d'Informàtica de Sistemes i Computadors es_ES
dc.description.bibliographicCitation Colás, A.; Varela, M.; Mraz, M.; Novak, D.; Cuesta Frau, D.; Vigil, L.; Benes, M.... (2020). Influence of glucometric 'dynamical' variables on Duodenal-Jejunal Bypass Liner (DJBL) anthropometric and metabolic outcomes. Diabetes/Metabolism Research and Reviews. 36(4):1-9. https://doi.org/10.1002/dmrr.3287 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/dmrr.3287 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 9 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 36 es_ES
dc.description.issue 4 es_ES
dc.identifier.pmid 31916665 es_ES
dc.relation.pasarela S\401352 es_ES
dc.contributor.funder Czech Technical University in Prague es_ES
dc.contributor.funder Ministry of Health, República Checa es_ES
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