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Polymorphisms in coding and non-coding regions of rabbit (Oryctolagus cuniculus) myogenin (MyoG) gene

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Polymorphisms in coding and non-coding regions of rabbit (Oryctolagus cuniculus) myogenin (MyoG) gene

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dc.contributor.author Migdał, Łukasz es_ES
dc.contributor.author Pałka, Sylwia es_ES
dc.date.accessioned 2021-07-06T07:02:56Z
dc.date.available 2021-07-06T07:02:56Z
dc.date.issued 2021-06-30
dc.identifier.issn 1257-5011
dc.identifier.uri http://hdl.handle.net/10251/168815
dc.description.abstract [EN] In animal breeding, selection based on growth is very often used, as this trait affects the profitability of animal production. Identification of  polymorphisms within the genes affecting the growth process seems to be very important. Therefore, we decided to analyse rabbit myogenin (MyoG gene) for potential polymorphic sites and their association with growth and carcass traits in Termond White (TER), Belgian Giant Grey (BGG) and crossbred New Zealand White×Belgian Giant Grey (NZW×BGG) rabbits. We found three single nucleotide polymorphisms (SNPs) – in 5’ upstream sequence g.68679476 C>T, in exon 1 – silent mutation g.68680096 T>C and g.68680097 G>A resulting in change of GTG triplet (valine) into ATG triplet (methionine). Association analysis showed that GG genotype weaning weight was statistically higher compared to GA in TER population (P=0.005), and that the hind parts for GG genotypes were heavier compared to those of GA (P=0.024), but association analysis of dissectible parts showed this was caused by higher bone weight (P=0.015). For g.68679476 C>T in NZW×BGG population, the CC genotypes for fore (678±35) and hind part (615±29) weights were heavier compared to CT (588±16 and 549±13, respectively); moreover, association analysis of dissectible parts showed that weight of dissectible meat in hind part. Unfortunately, we did not find similar associations for other analysed breeds. For g.68679476 C>T in NZWxBGG musculus longissimus lumborum pH leg after 24 h chilling (pH24L) were statistically lower for CC genotypes compared to CT (P=0.027). For g.68680097 G>A in Termond White population L* value on the hind leg after 24 h chilling (L*24H) was higher for GA genotypes compared to GG (P=0.03), while for g.68679476 C>T for musculus longissimus lumborum L* value after 24 h (L*24L) CC genotypes had higher value compared to CT (P=0.016) in BGG population. Moreover, in BGG population CT genotypes had higher weaning weight compared to CC (P=0.018). Our results show that SNPs within the MyoG gene may influence growth traits in some rabbit breeds, but the evolutionary conserved sequence may not be favourable for changes within coding sequences. For a better understanding thereof, additional analysis is required. es_ES
dc.description.sponsorship This research was financed by the National Centre for Research and Development (Poland) decision number LIDER/27/0104/L-9/17/NCBR/2018. es_ES
dc.language Inglés es_ES
dc.publisher Universitat Politècnica de València es_ES
dc.relation.ispartof World Rabbit Science es_ES
dc.rights Reconocimiento - No comercial - Compartir igual (by-nc-sa) es_ES
dc.subject Rabbits es_ES
dc.subject Myogenin es_ES
dc.subject Single nucleotide polymorphism es_ES
dc.subject Growth traits es_ES
dc.subject Slaughter traits es_ES
dc.title Polymorphisms in coding and non-coding regions of rabbit (Oryctolagus cuniculus) myogenin (MyoG) gene es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.4995/wrs.2021.11830
dc.relation.projectID info:eu-repo/grantAgreement/NCBR//LIDER%2F27%2F0104%2FL-9%2F17%2FNCBR%2F2014/ es_ES
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Migdał, Ł.; Pałka, S. (2021). Polymorphisms in coding and non-coding regions of rabbit (Oryctolagus cuniculus) myogenin (MyoG) gene. World Rabbit Science. 29(2):69-79. https://doi.org/10.4995/wrs.2021.11830 es_ES
dc.description.accrualMethod OJS es_ES
dc.relation.publisherversion https://doi.org/10.4995/wrs.2021.11830 es_ES
dc.description.upvformatpinicio 69 es_ES
dc.description.upvformatpfin 79 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 29 es_ES
dc.description.issue 2 es_ES
dc.identifier.eissn 1989-8886
dc.relation.pasarela OJS\11830 es_ES
dc.contributor.funder National Centre for Research and Development, Polonia es_ES
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