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dc.contributor.author | Andrés, Diana | es_ES |
dc.contributor.author | Jiménez-Gambín, Sergio | es_ES |
dc.contributor.author | Jimenez, Noe | es_ES |
dc.contributor.author | Camarena Femenia, Francisco | es_ES |
dc.date.accessioned | 2021-12-27T08:37:50Z | |
dc.date.available | 2021-12-27T08:37:50Z | |
dc.date.issued | 2020-09-11 | es_ES |
dc.identifier.isbn | 978-1-7281-5448-0 | es_ES |
dc.identifier.issn | 1948-5727 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/178930 | |
dc.description.abstract | [EN] Single-element focused ultrasound devices have demonstrated its ability to non-invasively open the Blood Brain Barrier. However, skull irregularities and absorption produce strong aberrations in the ultrasound focus. Recently, 3D-printed acoustic holograms were used to compensate aberrations and to produce a sharp focus. In addition, using this technology the geometry of the ultrasonic focus can be matched to the shape of the brain structure of interest. In this work, we experimentally and numerically report 3D-printed acoustic holograms for bilateral focusing through an ex-vivo human skull. Using holograms, we target different cerebral nuclei and the ultrasonic focuses are adapted to the target volumes, minimizing the acoustic field outside. Simultaneously, skull aberrations are corrected using phased-conjugation methods. The holographic surfaces were manufactured for a 100-mm aperture and 140-mm focal focused transducer at 500 kHz to focus through an ex-vivo human skull. Numerical and experimental results agree targeting several deep-brain nuclei: left-and-right putamen, caudate nuclei, and hippocampi, showing the potential of this low-cost technology to optimize BBBO or neuromodulation treatments. | es_ES |
dc.description.sponsorship | This research has been supported by the Spanish Ministry of Science, Innovation and Universities through grant Juan de la Cierva - Incorporacion (IJC2018-037897-I) and PID2019-111436RBC22, by the Agencia Valenciana de la Innovacio through grants INNVAL10/19/016 and INNCON/2020/009. Action cofinanced by the European Union through the Programa Operativo del Fondo Europeo de Desarrollo Regional (FEDER) of the Comunitat Valenciana 2014-2020 (IDIFEDER/2018/022). | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | IEEE | es_ES |
dc.relation.ispartof | Proceedings of the 2020 IEEE International Ultrasonics Symposium (IUS) | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Acoustic holograms | es_ES |
dc.subject | Therapeutic ultrasound | es_ES |
dc.subject | Neuromodulation | es_ES |
dc.subject | Blood-brain barrier opening | es_ES |
dc.subject.classification | FISICA APLICADA | es_ES |
dc.title | Multifocal acoustic holograms for deep-brain neuromodulation and BBB opening | es_ES |
dc.type | Comunicación en congreso | es_ES |
dc.type | Artículo | es_ES |
dc.type | Capítulo de libro | es_ES |
dc.identifier.doi | 10.1109/IUS46767.2020.9251769 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111436RB-C22/ES/NEW TECHNIQUES FOR MULTIMODAL MOLECULAR ELASTOGRAPHIC IMAGING/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AVI//INNVAL10%2F19%2F016/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AVI//INNCON%2F2020%2F009/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//IDIFEDER%2F2018%2F022//EQUIPOS PARA TECNICAS MIXTAS ELECTROMAGNETICAS-ULTRASONICAS PARA IMAGEN MEDICA/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement///IJC2018-037897-I//AYUDA JUAN DE LA CIERVA INCORPORACION-JIMENEZ GONZALEZ/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada | es_ES |
dc.description.bibliographicCitation | Andrés, D.; Jiménez-Gambín, S.; Jimenez, N.; Camarena Femenia, F. (2020). Multifocal acoustic holograms for deep-brain neuromodulation and BBB opening. IEEE. 1-3. https://doi.org/10.1109/IUS46767.2020.9251769 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.conferencename | 2020 IEEE International Ultrasonics Symposium (IUS) | es_ES |
dc.relation.conferencedate | Septiembre 07-11,2020 | es_ES |
dc.relation.conferenceplace | Online | es_ES |
dc.relation.publisherversion | https://doi.org/10.1109/IUS46767.2020.9251769 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 3 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.relation.pasarela | S\422333 | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Agència Valenciana de la Innovació | es_ES |