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dc.contributor.author | Sánchez, Jorge | es_ES |
dc.contributor.author | Nothstein Mark | es_ES |
dc.contributor.author | Unger, Laura | es_ES |
dc.contributor.author | Saiz Rodríguez, Francisco Javier | es_ES |
dc.contributor.author | Trenor Gomis, Beatriz Ana | es_ES |
dc.contributor.author | Dossel, Olaf | es_ES |
dc.contributor.author | Loewe, Axel | es_ES |
dc.date.accessioned | 2022-02-17T07:20:55Z | |
dc.date.available | 2022-02-17T07:20:55Z | |
dc.date.issued | 2019-09-11 | es_ES |
dc.identifier.isbn | 978-1-7281-6936-1 | es_ES |
dc.identifier.issn | 2325-887X | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/180930 | |
dc.description.abstract | [EN] Under persistent atrial fibrillation (peAF), cardiac tissue experiences electrophysiological and structural remodeling. Fibrosis in the atrial tissue has an important impact on the myocyte action potential and its propagation. The objective of this work is to explore the effect of heterogeneities present in the fibrotic tissue and their impact on the intracardiac electrogram (EGM). Human atrial myocyte and fibroblast electrophysiology was simulated using mathematical models proposed by Koivumäki et al. to represent electrical remodeling under peAF and the paracrine effect of the transforming grow factor ¿1 (TGF-¿1). 2D tissue simulations were computed varying the density of fibrosis (10%, 20% and 40%), myofibroblasts and collagen were randomly distributed with different ratios (0%-100%, 50%-50% and 100%- 0%). Results show that increasing the fibrosis density changes the re-entry dynamics from functional to anatomical due to a block in conduction in regions with high fibrosis density (40%). EGM morphology was affected by different ratios of myofibroblasts-collagen. For low myofibroblast densities (below 50%) the duration of active segments was shorter compared to higher myofibroblasts densities (above 50%). Our results show that fibrosis heterogeneities can alter the dynamics of the re-entry and the morphology of the EGM. | es_ES |
dc.description.sponsorship | We gratefully acknowledge financial support by Deutsche Forschungsgemeinschaft (DFG) under grant LO 2093/1-1. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | IEEE | es_ES |
dc.relation.ispartof | 2019 Computing in Cardiology (CinC). Proceedings | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject.classification | TECNOLOGIA ELECTRONICA | es_ES |
dc.title | Influence of Fibrotic Tissue Arrangement on Intracardiac Electrograms During Persistent Atrial Fibrillation | es_ES |
dc.type | Comunicación en congreso | es_ES |
dc.type | Artículo | es_ES |
dc.type | Capítulo de libro | es_ES |
dc.identifier.doi | 10.22489/CinC.2019.342 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/DFG//LO2093%2F1-1/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement///PROMETEO%2F2016%2F088//MODELOS COMPUTACIONALES PERSONALIZADOS MULTI-ESCALA PARA LA OPTIMIZACION DEL DIAGNOSTICO Y TRATAMIENTO DE ARRITMIAS CARDIACAS (PERSONALISED DIGITAL HEART)/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI//DPI2016-75799-R//TECNOLOGIAS COMPUTACIONALES PARA LA OPTIMIZACION DE TERAPIAS PERSONALIZADAS DE PATOLOGIAS AURICULARES Y VENTRICULARES/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica | es_ES |
dc.description.bibliographicCitation | Sánchez, J.; Nothstein Mark; Unger, L.; Saiz Rodríguez, FJ.; Trenor Gomis, BA.; Dossel, O.; Loewe, A. (2019). Influence of Fibrotic Tissue Arrangement on Intracardiac Electrograms During Persistent Atrial Fibrillation. IEEE. 1-4. https://doi.org/10.22489/CinC.2019.342 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.conferencename | 46th Computing in Cardiology Conference (CinC 2019) | es_ES |
dc.relation.conferencedate | Septiembre 08-11,2019 | es_ES |
dc.relation.conferenceplace | Singapore | es_ES |
dc.relation.publisherversion | https://doi.org/10.22489/CinC.2019.342 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 4 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.relation.pasarela | S\396361 | es_ES |
dc.contributor.funder | Deutsche Forschungsgemeinschaft | es_ES |