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dc.contributor.author | Anitua, Eduardo | es_ES |
dc.contributor.author | Cerqueira, Andreia | es_ES |
dc.contributor.author | Romero-Gavilán, Francisco | es_ES |
dc.contributor.author | García-Arnáez, Iñaki | es_ES |
dc.contributor.author | Martínez-Ramos, Cristina | es_ES |
dc.contributor.author | Ozturan, Seda | es_ES |
dc.contributor.author | Azkargorta, Mikel | es_ES |
dc.contributor.author | Elortza, Félix | es_ES |
dc.contributor.author | Gurruchaga, Mariló | es_ES |
dc.contributor.author | Goñi, Isabel | es_ES |
dc.contributor.author | Suay, Julio | es_ES |
dc.contributor.author | Tejero, Ricardo | es_ES |
dc.date.accessioned | 2022-04-05T06:55:13Z | |
dc.date.available | 2022-04-05T06:55:13Z | |
dc.date.issued | 2021-04-21 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/181802 | |
dc.description.abstract | [EN] Background Calcium (Ca) is a well-known element in bone metabolism and blood coagulation. Here, we investigate the link between the protein adsorption pattern and the in vivo responses of surfaces modified with calcium ions (Ca-ion) as compared to standard titanium implant surfaces (control). We used LC-MS/MS to identify the proteins adhered to the surfaces after incubation with human serum and performed bilateral surgeries in the medial section of the femoral condyles of 18 New Zealand white rabbits to test osseointegration at 2 and 8 weeks post-implantation (n=9). Results Ca-ion surfaces adsorbed 181.42 times more FA10 and 3.85 times less FA12 (p<0.001), which are factors of the common and the intrinsic coagulation pathways respectively. We also detected differences in A1AT, PLMN, FA12, KNG1, HEP2, LYSC, PIP, SAMP, VTNC, SAA4, and CFAH (p<0.01). At 2 and 8 weeks post-implantation, the mean bone implant contact (BIC) with Ca-ion surfaces was respectively 1.52 and 1.25 times higher, and the mean bone volume density (BVD) was respectively 1.35 and 1.13 times higher. Differences were statistically significant for BIC at 2 and 8 weeks and for BVD at 2 weeks (p<0.05). Conclusions The strong thrombogenic protein adsorption pattern at Ca-ion surfaces correlated with significantly higher levels of implant osseointegration. More effective implant surfaces combined with smaller implants enable less invasive surgeries, shorter healing times, and overall lower intervention costs, especially in cases of low quantity or quality of bone. | es_ES |
dc.description.sponsorship | This work was supported by Universitat Jaume I under [POSDOC/2019/28], Generalitat Valenciana [GRISOLIAP/2018/091], University of the Basque Country under [UFI11/56], and Basque Government under [PRE_2017_2_0044]. CIC bioGUNE is supported by Basque Department of Industry, Tourism and Trade (Etortek and Elkartek programs), the Innovation Technology Department of the Bizkaia County; The ProteoRed-ISCIII (Grant PRB3 IPT17/0019); and CIBERehd Network and Severo Ochoa Grant (SEV-2016-0644). | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Springer (Biomed Central Ltd.) | es_ES |
dc.relation.ispartof | International Journal of Implant Dentistry | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Titanium implants | es_ES |
dc.subject | Osseointegration | es_ES |
dc.subject | Blood coagulation | es_ES |
dc.subject | Implant surface design | es_ES |
dc.subject | Protein adsorption | es_ES |
dc.subject.classification | CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA | es_ES |
dc.title | Influence of calcium ion-modified implant surfaces in protein adsorption and implant integration | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1186/s40729-021-00314-1 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/UJI//POSDOC%2F2019%2F28/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//GRISOLIAP%2F2018%2F091/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/Eusko Jaurlaritza//PRE_2017_2_0044/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/UPV/EHU//UFI11%2F56/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//SEV-2016-0644/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII//PRB3 IPT17%2F0019/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada | es_ES |
dc.description.bibliographicCitation | Anitua, E.; Cerqueira, A.; Romero-Gavilán, F.; García-Arnáez, I.; Martínez-Ramos, C.; Ozturan, S.; Azkargorta, M.... (2021). Influence of calcium ion-modified implant surfaces in protein adsorption and implant integration. International Journal of Implant Dentistry. 7(1):1-11. https://doi.org/10.1186/s40729-021-00314-1 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1186/s40729-021-00314-1 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 11 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 7 | es_ES |
dc.description.issue | 1 | es_ES |
dc.identifier.eissn | 2198-4034 | es_ES |
dc.identifier.pmid | 33880662 | es_ES |
dc.identifier.pmcid | PMC8058122 | es_ES |
dc.relation.pasarela | S\458185 | es_ES |
dc.contributor.funder | Eusko Jaurlaritza | es_ES |
dc.contributor.funder | Universitat Jaume I | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |
dc.contributor.funder | Universidad del País Vasco/Euskal Herriko Unibertsitatea | es_ES |
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