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dc.contributor.author | Villalba-Bermell, Pascual | es_ES |
dc.contributor.author | Marquez-Molins, Joan | es_ES |
dc.contributor.author | Marques, María-Carmen | es_ES |
dc.contributor.author | Hernandez-Azurdia, Andrea G. | es_ES |
dc.contributor.author | Corell-Sierra, Julia | es_ES |
dc.contributor.author | Picó Sirvent, María Belén | es_ES |
dc.contributor.author | Monforte Gilabert, Antonio José | es_ES |
dc.contributor.author | ELENA FITO, SANTIAGO FCO | es_ES |
dc.contributor.author | Gomez, Gustavo Germán | es_ES |
dc.date.accessioned | 2022-06-16T18:05:36Z | |
dc.date.available | 2022-06-16T18:05:36Z | |
dc.date.issued | 2021-11-25 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/183401 | |
dc.description.abstract | [EN] Climate change has been associated with a higher incidence of combined adverse environmental conditions that can promote a significant decrease in crop productivity. However, knowledge on how a combination of stresses might affect plant development is still scarce. MicroRNAs (miRNAs) have been proposed as potential targets for improving crop productivity. Here, we have combined deep-sequencing, computational characterization of responsive miRNAs and validation of their regulatory role in a comprehensive analysis of response of melon to several combinations of four stresses (cold, salinity, short day, and infection with a fungus). Twenty-two miRNA families responding to double and/or triple stresses were identified. The regulatory role of the differentially expressed miRNAs was validated by quantitative measurements of the expression of the corresponding target genes. A high proportion (ca. 60%) of these families (mainly highly conserved miRNAs targeting transcription factors) showed a non-additive response to multiple stresses in comparison with that observed under each one of the stresses individually. Among those miRNAs showing non-additive response to stress combinations, most interactions were negative, suggesting the existence of functional convergence in the miRNA-mediated response to combined stresses. Taken together, our results provide compelling pieces of evidence that the response to combined stresses cannot be easily predicted from the study individual stresses. | es_ES |
dc.description.sponsorship | This work was supported by grants PID2019-104126RB-I00 (GG), PIE2019-103998GB-I00 (SE), and AGL2017-85563-C2-1R (BP) funded byMCIN/Spain's Agencia Estatal de Investigacion (AEI) and "ERDF A way of making Europe" and by PROMETEO projects 2019/012 (SE) and 2017/078 and 2021/072 (BP) (to promote excellence groups) by the Conselleria d'Educacio, Investigacio, Cultura i Esports (Generalitat Valenciana). JM-M (ACIF-2017-114) and AH-A (ACIF-2021-202) are recipients of a predoctoral contract from the Generalitat Valenciana. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Frontiers Media SA | es_ES |
dc.relation.ispartof | Frontiers in Plant Science | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Crop production and climate change | es_ES |
dc.subject | MiRNAs and stress response in Cucumis melo | es_ES |
dc.subject | RNA regulatory networks | es_ES |
dc.subject | RNA-seq and systems biology | es_ES |
dc.subject | Biotic and abiotic stress | es_ES |
dc.subject.classification | GENETICA | es_ES |
dc.title | Combined Stress Conditions in Melon Induce Non-additive Effects in the Core miRNA Regulatory Network | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.3389/fpls.2021.769093 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-85563-C2-1-R/ES/CONTROL MULTIDISCIPLINAR DE ENFERMEDADES FUNGICAS Y VIROSIS EN MELON Y SANDIA: UN NUEVO RETO/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//ACIF%2F2017%2F114/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-103998GB-I00/ES/PAPEL DEL CODIGO EPIGENOMICO DEL HUESPED EN LA EVOLUCION DE LAS POBLACIONES VIRALES/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEO%2F2021%2F072/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104126RB-I00/ES/REDES REGULADORAS GENICAS INFLUENCIADAS POR EL AMBIENTE IMPLICADAS EN EL CONTROL DE LA REPUESTA A ESTRES EN MELON/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//ACIF%2F2021%2F202/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEO%2F2019%2F012/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEO%2F2017%2F078//Selección de variedades tradicionales y desarrollo de nuevas variedades de cucurbitáceas adaptadas a la producción ecológica/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia | es_ES |
dc.description.bibliographicCitation | Villalba-Bermell, P.; Marquez-Molins, J.; Marques, M.; Hernandez-Azurdia, AG.; Corell-Sierra, J.; Picó Sirvent, MB.; Monforte Gilabert, AJ.... (2021). Combined Stress Conditions in Melon Induce Non-additive Effects in the Core miRNA Regulatory Network. Frontiers in Plant Science. 12:1-15. https://doi.org/10.3389/fpls.2021.769093 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.3389/fpls.2021.769093 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 15 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 12 | es_ES |
dc.identifier.eissn | 1664-462X | es_ES |
dc.identifier.pmid | 34899791 | es_ES |
dc.identifier.pmcid | PMC8656716 | es_ES |
dc.relation.pasarela | S\459702 | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |