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dc.contributor.author | Moussa, Hanan | es_ES |
dc.contributor.author | El Hadad, Amir | es_ES |
dc.contributor.author | Sarrigiannidis, Stylianos | es_ES |
dc.contributor.author | Saad, Ahmed | es_ES |
dc.contributor.author | Wang, Min | es_ES |
dc.contributor.author | Taqi, Doaa | es_ES |
dc.contributor.author | Al-Hamed, Faez Saleh | es_ES |
dc.contributor.author | Salmerón Sánchez, Manuel | es_ES |
dc.contributor.author | Cerruti, Marta | es_ES |
dc.contributor.author | Tamimi, Faleh | es_ES |
dc.date.accessioned | 2022-12-05T19:00:26Z | |
dc.date.available | 2022-12-05T19:00:26Z | |
dc.date.issued | 2021-08 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/190515 | |
dc.description.abstract | [EN] The ideal bone substitute material should be mechanically strong, biocompatible with a resorption rate matching the rate of new bone formation. Brushite (dicalcium phosphate dihydrate) cement is a promising bone substitute material but with limited resorbability and mechanical properties. To improve the resorbability and mechanical performance of brushite cements, we incorporated gypsum (calcium sulfate dihydrate) and diazonium-treated polyglactin fibers which are well-known for their biocompatibility and bioresorbability. Here we show that by combining brushite and gypsum, we were able to fabricate biocompatible composite cements with high fracture toughness (0.47 MPa center dot m1/2) and a resorption rate that matched the rate of new bone formation. Adding functionalized polyglactin fibers to this composite cement further improved the fracture toughness up to 1.00 MPa center dot m1/2. XPS and SEM revealed that the improvement in fracture toughness is due to the strong interfacial bonding between the functionalized fibers and the cement matrix. This study shows that adding gypsum and functionalized polyglactin fibers to brushite cements results in composite biomaterials that combine high fracture toughness, resorbability, and biocompatibility, and have great potential for bone regeneration. | es_ES |
dc.description.sponsorship | We thank Dr. David Liu, for assistance with the mineral characterization and McGill University's Facility for Electron Microscopy Research (FEMR) for assisting in many ways with this work. This study was supported by the Libyan Ministry of Education and Scientific Research (H. M.) , the Canadian Foundation for Innovation (CFI, F.T.) , NSERC Discovery Grants RGPIN-2019-04340 (F.T.) , "Le Reseau de recherche en sante buccodentaire et osseuse" (RSBO) , and the Canada Research Chair program (F.T. and M.C.) . MS-S acknowledges support from the UK Engineering and Physical Sciences Research Council (EPSRCEP/P001114/1) . | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier BV | es_ES |
dc.relation.ispartof | Materials Science and Engineering C: Biomimetic materials, sensors and systems (Online) | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Brushite | es_ES |
dc.subject | Gypsum cements | es_ES |
dc.subject | Polyglactin fibers | es_ES |
dc.subject | Fracture toughness | es_ES |
dc.subject | Resorbability | es_ES |
dc.subject | Diazonium treatment | es_ES |
dc.subject.classification | FISICA APLICADA | es_ES |
dc.title | High toughness resorbable brushite-gypsum fiber-reinforced cements | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.msec.2021.112205 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/NSERC//RGPIN-2019-04340/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EPSRC//EP%2FP001114%2F1/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials | es_ES |
dc.description.bibliographicCitation | Moussa, H.; El Hadad, A.; Sarrigiannidis, S.; Saad, A.; Wang, M.; Taqi, D.; Al-Hamed, FS.... (2021). High toughness resorbable brushite-gypsum fiber-reinforced cements. Materials Science and Engineering C: Biomimetic materials, sensors and systems (Online). 127:1-11. https://doi.org/10.1016/j.msec.2021.112205 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.msec.2021.112205 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 11 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 127 | es_ES |
dc.identifier.eissn | 1873-0191 | es_ES |
dc.identifier.pmid | 34225857 | es_ES |
dc.relation.pasarela | S\463327 | es_ES |
dc.contributor.funder | Canada Research Chairs | es_ES |
dc.contributor.funder | Canada Foundation for Innovation | es_ES |
dc.contributor.funder | Natural Sciences and Engineering Research Council of Canada | es_ES |
dc.contributor.funder | Engineering and Physical Sciences Research Council, Reino Unido | es_ES |