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Lab-on-a-chip based integrated hybrid technologies for biofluids manipulation and characterization

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Lab-on-a-chip based integrated hybrid technologies for biofluids manipulation and characterization

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dc.contributor.author ROCHA GASO, MARÍA ISABEL es_ES
dc.contributor.author Renaudin, A. es_ES
dc.contributor.author Sarry, F. es_ES
dc.contributor.author Beyssen, D. es_ES
dc.date.accessioned 2023-02-28T19:00:50Z
dc.date.available 2023-02-28T19:00:50Z
dc.date.issued 2015 es_ES
dc.identifier.issn 1877-7058 es_ES
dc.identifier.uri http://hdl.handle.net/10251/192162
dc.description.abstract [EN] The goal of this work is to develop an original and high performance hybrid lab-on-a-chip, coupling actuators and biosensors for the active control and broad range characterization of biofluids samples. These biofluids will be controlled (moved and mixed) actively by Rayleigh-Surface Acoustic Wave (R-SAW) and analysed in real-time by combining Love-SAW (L-SAW) and Surface Plasmon Resonance (SPR) technologies. A microfluidic chamber and specific transducer were designed for this application to interact efficiently with the liquid sample entrapped in the chamber and to detect modifications of its physical properties such as viscosity. AT-cut quartz and LiNbO3 36Y-X substrates were used to generate both Rayleigh and Shear-Horizontal waves and ZnO material as guiding layer. The whole system has proven is full efficiency to interact with the fluid and to detect the signal perturbations with no significant loss compared with the measurements carried out with a probe station. es_ES
dc.description.sponsorship The authors wish to thank the ANR for its financial support through the AWESOM project (ANR-12-BS09-021); the operators Laurent Bouvot, Jean Georges Mussot and Emmanuel Vatoux, for their support and assistance in the fabrication of the cell and the SAW devices; and the engineering students, Olivier Bettoni and Bastien Lafont, for their contribution to the cell design. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Procedia Engineering es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Microfluidic es_ES
dc.subject Surface Acoustic Waves (SAW) es_ES
dc.subject Love wave es_ES
dc.subject Rayleigh wave es_ES
dc.subject ZnO es_ES
dc.subject AT-cut quartz es_ES
dc.subject LiNbO3 36Y-X es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Lab-on-a-chip based integrated hybrid technologies for biofluids manipulation and characterization es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.proeng.2015.08.750 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ANR//ANR-12-BS09-021/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny es_ES
dc.description.bibliographicCitation Rocha Gaso, MI.; Renaudin, A.; Sarry, F.; Beyssen, D. (2015). Lab-on-a-chip based integrated hybrid technologies for biofluids manipulation and characterization. Procedia Engineering. 120:687-690. https://doi.org/10.1016/j.proeng.2015.08.750 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.proeng.2015.08.750 es_ES
dc.description.upvformatpinicio 687 es_ES
dc.description.upvformatpfin 690 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 120 es_ES
dc.relation.pasarela S\482512 es_ES
dc.contributor.funder Agence Nationale de la Recherche, Francia es_ES
dc.description.references G. Destgeer and H. J. Sung, “Recent advances in microfluidic actuation and micro-object manipulation via surface acoustic waves,” Lab Chip, 2015. es_ES
dc.description.references M. I. Rocha-Gaso, J. García, P. García, C. March-iborra, Y. Jiménez, L. Francis, Á. Montoya, and A. Arnau, “Love Wave Immunosensor for the Detection of Carbaryl Pesticide,” Sensors, pp. 16434-16453, 2014. es_ES
dc.description.references J. G. G. Luz, D.E. P. Souto, G.F. Machado-Assis, M. de Lana, L.T. Kubota, R.C. S. Luz, F.S. Damos, and H. R. Martins, “Development and Evaluation of a SPR-based Immunosensor for Detection of Anti-Trypanosoma cruzi Antibodies in Human Serum,” Sensors Actuators B Chem., vol. 212, pp. 287-296, 2015. es_ES
dc.description.references L. El Fissi, Détection et mesure de nanoparticules pour les applications de capteurs en milieu liquide,“Université de Franche-Comté, 2009. es_ES
dc.description.references K. Kalantar, A. Trinchi, W. Wlodarski, and A. Holland, “A novel Love-mode device based on a ZnO/ST-cut quartz crystal structure for sensing applications,” Sensors And Actuators, vol. 100, pp. 135-143, 2002. es_ES
dc.description.references F. Moreira, M. El Hakiki, O. Elmazria, F. Sarry, L. Le Brizoual, and P. Alnot, “Theoretical and experimental identification of love wave frequency peaks in layered structure ZnO/Quartz SAW device,” IEEE Sens. J., vol. 8, no. 8, pp. 1399-1403, 2008. es_ES


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