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dc.contributor.author | Monreal-Trigo, Javier | es_ES |
dc.contributor.author | Alcañiz Fillol, Miguel | es_ES |
dc.contributor.author | Martínez-Bisbal, M.Carmen | es_ES |
dc.contributor.author | Loras, Alba | es_ES |
dc.contributor.author | Pascual, Lluís | es_ES |
dc.contributor.author | Ruiz-Cerdá, José Luis | es_ES |
dc.contributor.author | Ferrer, Alberto | es_ES |
dc.contributor.author | Martínez-Máñez, Ramón | es_ES |
dc.date.accessioned | 2023-03-24T19:01:09Z | |
dc.date.available | 2023-03-24T19:01:09Z | |
dc.date.issued | 2022-09-16 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/192594 | |
dc.description.abstract | [EN] Bladder cancer (BC) is the sixth leading cause of death by cancer. Depending on the invasiveness of tumors, patients with BC will undergo surgery and surveillance lifelong, owing the high rate of recurrence and progression. In this context, the development of strategies to support non-invasive BC diagnosis is focusing attention. Voltammetric electronic tongue (VET) has been demonstrated to be of use in the analysis of biofluids. Here, we present the implementation of a VET to study 207 urines to discriminate BC and non-BC for diagnosis and surveillance to detect recurrences. Special attention has been paid to the experimental setup to improve reproducibility in the measurements. PLSDA analysis together with variable selection provided a model with high sensitivity, specificity, and area under the ROC curve AUC (0.844, 0.882, and 0.917, respectively). These results pave the way for the development of non-invasive low- cost and easy-touse strategies to support BC diagnosis and follow-up. | es_ES |
dc.description.sponsorship | This research was supported by the Spanish Ministry of Science, Innovation and Universities via a doctoral grant to the first author (FPU17/03239). Authors gratefully acknowledge the financial support of RTI2018-100910-B-C41 and RTI2018-100910-B-C43 (funded by MCIN/AEI/10.13039/501100011033/and FEDER A way to make Europe) and PROMETEO/2018/024 (the Generalitat Valenciana) projects. Authors also gratefully acknowledge CIBER-BBN. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier (Cell Press) | es_ES |
dc.relation.ispartof | iScience | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject.classification | ESTADISTICA E INVESTIGACION OPERATIVA | es_ES |
dc.subject.classification | QUIMICA INORGANICA | es_ES |
dc.subject.classification | TECNOLOGIA ELECTRONICA | es_ES |
dc.title | New bladder cancer non-invasive surveillance method based on voltammetric electronic tongue measurement of urine | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.isci.2022.104829 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-100910-B-C41/ES/MATERIALES POROSOS INTELIGENTES MULTIFUNCIONALES Y DISPOSITIVOS ELECTRONICOS PARA LA LIBERACION DE FARMACOS, DETECCION DE DROGAS Y BIOMARCADORES Y COMUNICACION A NANOESCALA/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ //FPU17%2F03239//AYUDA CONTRATO PREDOCTORAL FPU-MONREAL TRIGO. PROYECTO: REGENERACION DE TEJIDO NERVIOSO MEDIANTE ELECTROESTIMULACION Y LIBERACION ELECTROQUIMICA CONTROLADA DE FARMACOS/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-100910-B-C43/ES/DESARROLLO DE PLATAFORMAS DE DETECCION Y TERAPEUTICAS PARA APLICACIONES BIOMEDICAS BASADAS EN DISPOSITIVOS ELECTRONICOS/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEO%2F2018%2F024//Sistemas avanzados de liberación controlada/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny | es_ES |
dc.description.bibliographicCitation | Monreal-Trigo, J.; Alcañiz Fillol, M.; Martínez-Bisbal, M.; Loras, A.; Pascual, L.; Ruiz-Cerdá, JL.; Ferrer, A.... (2022). New bladder cancer non-invasive surveillance method based on voltammetric electronic tongue measurement of urine. iScience. 25(9):1-14. https://doi.org/10.1016/j.isci.2022.104829 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.isci.2022.104829 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 14 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 25 | es_ES |
dc.description.issue | 9 | es_ES |
dc.identifier.eissn | 2589-0042 | es_ES |
dc.identifier.pmid | 36034216 | es_ES |
dc.identifier.pmcid | PMC9399275 | es_ES |
dc.relation.pasarela | S\472096 | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | AGENCIA ESTATAL DE INVESTIGACION | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | MINISTERIO DE CIENCIA E INNOVACION | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina | es_ES |