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Residual ST-segment elevation to predict long-term clinical and CMR-derived outcomes in STEMI

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Residual ST-segment elevation to predict long-term clinical and CMR-derived outcomes in STEMI

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dc.contributor.author Merenciano-Gonzalez, Héctor es_ES
dc.contributor.author Marcos-Garces, Victor es_ES
dc.contributor.author Gavara-Doñate, Josep es_ES
dc.contributor.author Pedro-Tudela, Ana es_ES
dc.contributor.author Lopez-Lereu, Maria P. es_ES
dc.contributor.author Monmeneu, José V. es_ES
dc.contributor.author Pérez, Nerea es_ES
dc.contributor.author Rios-Navarro, César es_ES
dc.contributor.author De Dios, Elena es_ES
dc.contributor.author Gabaldon-Perez, Ana es_ES
dc.contributor.author Albiach, Cristina es_ES
dc.contributor.author Racugno, Paolo es_ES
dc.contributor.author Bonanad, Clara es_ES
dc.contributor.author Canoves, Joaquim es_ES
dc.contributor.author Chorro, Francisco J. es_ES
dc.contributor.author Bodi, Vicente es_ES
dc.date.accessioned 2023-05-12T18:01:57Z
dc.date.available 2023-05-12T18:01:57Z
dc.date.issued 2022-12-17 es_ES
dc.identifier.issn 2045-2322 es_ES
dc.identifier.uri http://hdl.handle.net/10251/193320
dc.description.abstract [EN] Residual ST-segment elevation after ST-segment elevation myocardial infarction (STEMI) has traditionally been considered a predictor of left ventricular (LV) dysfunction and ventricular aneurism. However, the implications in terms of long-term prognosis and cardiac magnetic resonance (CMR)-derived structural consequences are unclear. A total of 488 reperfused STEMI patients were prospectively included. The number of Q wave leads with residual ST-segment elevation> 1 mm (Q-STE) at pre-discharge ECG was assessed. LV ejection fraction (LVEF, %) and infarct size (IS, % of LV mass) were quantifed in 319 patients at 6-month CMR. Major adverse cardiac events (MACE) were defned as all-cause death and/or re-admission for acute heart failure (HF), whichever occurred frst. During a mean follow-up of 6.1 years, 92 MACE (18.9%), 39 deaths and 53 HF were recorded. After adjustment for baseline characteristics, Q-STE (per lead with> 1 mm) was independently associated with a higher risk of long-term MACE (HR 1.24 [1.07¿1.44] per lead, p = 0.004), reduced (< 40%) LVEF (HR 1.36 [1.02¿1.82] per lead, p = 0.04) and large (> 30% of LV mass) IS (HR 1.43 [1.11¿1.85] per lead, p = 0.006) at 6-month CMR. Patients with Q-STE¿ 2 leads (n= 172, 35.2%) displayed lower MACE-free survival, more depressed LVEF, and larger IS at 6-month CMR (p< 0.001 for all comparisons). Residual ST-segment elevation after STEMI represents a universally available tool that predicts worse longterm clinical and CMR-derived structural outcomes. es_ES
dc.description.sponsorship This work was supported by the Instituto de Salud Carlos III and co-funded by Fondo Europeo de Desarrollo Regional (FEDER) (Grants PI20/00637 and CIBERCV16/11/00486, postgraduate contract FI18/00320 to C.R.-N. and CM21/00175 to V.M.-G.), Generalitat Valenciana (Grant PROMETEO/2021/008), and by Sociedad Espanola de Cardiologia (Grant SEC/FECINV-CLI 21/024). J. G. acknowledges financial support from the Agencia Estatal de Investigacion (Grant FJC2020-043981-I/AEI/). es_ES
dc.language Inglés es_ES
dc.publisher Nature Publishing Group es_ES
dc.relation.ispartof Scientific Reports es_ES
dc.rights Reconocimiento (by) es_ES
dc.title Residual ST-segment elevation to predict long-term clinical and CMR-derived outcomes in STEMI es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1038/s41598-022-26082-5 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00637/ES/RESOLUCION DE LA OBSTRUCCION MICROVASCULAR TRAS UN INFARTO DE MIOCARDIO: EVALUACION DE LAS CONSECUENCIAS ESTRUCTURALES Y CLINICAS Y BUSQUEDA DE NUEVAS OPCIONES TERAPEUTICAS./ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2021%2F008/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CB16%2F11%2F00486/ES/ENFERMEDADES CARDIOVASCULARES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//FI18%2F00320/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//CM21%2F00175/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Sociedad Española de Cardiología//SEC%2FFECINV-CLI 21%2F024/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI//FJC2020-043981-I/ es_ES
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Merenciano-Gonzalez, H.; Marcos-Garces, V.; Gavara-Doñate, J.; Pedro-Tudela, A.; Lopez-Lereu, MP.; Monmeneu, JV.; Pérez, N.... (2022). Residual ST-segment elevation to predict long-term clinical and CMR-derived outcomes in STEMI. Scientific Reports. 12(1):1-12. https://doi.org/10.1038/s41598-022-26082-5 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1038/s41598-022-26082-5 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 12 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 12 es_ES
dc.description.issue 1 es_ES
dc.identifier.pmid 36528716 es_ES
dc.identifier.pmcid PMC9759567 es_ES
dc.relation.pasarela S\481717 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Sociedad Española de Cardiología es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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