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A new brain dedicated PET scanner with 4D detector information

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A new brain dedicated PET scanner with 4D detector information

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dc.contributor.author González-Montoro, Andrea es_ES
dc.contributor.author Barbera Ballester, Julio es_ES
dc.contributor.author Sanchez-Gonzalo, David es_ES
dc.contributor.author Mondejar, Álvaro es_ES
dc.contributor.author Freire-López-Fando, Marta es_ES
dc.contributor.author Díaz González, Karel es_ES
dc.contributor.author Lucero-Ruiz, Alejandro es_ES
dc.contributor.author Jiménez-Serrano, Santiago es_ES
dc.contributor.author Alamo Valenzuela, Jorge es_ES
dc.contributor.author Morera Ballester, Constantino es_ES
dc.contributor.author Barrio-Toala, John es_ES
dc.contributor.author Cucarella, Neus es_ES
dc.contributor.author Ilisie, Victor es_ES
dc.contributor.author Moliner Martínez, Laura es_ES
dc.contributor.author Valladares de-Francisco, Celia es_ES
dc.contributor.author González Martínez, Antonio Javier es_ES
dc.contributor.author John Prior es_ES
dc.contributor.author Benlloch Baviera, Jose María es_ES
dc.date.accessioned 2023-07-12T18:00:51Z
dc.date.available 2023-07-12T18:00:51Z
dc.date.issued 2022-12 es_ES
dc.identifier.issn 1895-9091 es_ES
dc.identifier.uri http://hdl.handle.net/10251/194867
dc.description.abstract [EN] In this article, we present the geometrical design and preliminary results of a high sensitivity organ-specific Positron Emission Tomography (PET) system dedicated to the study of the human brain. The system, called 4D-PET, will allow accurate imaging of brain studies due to its expected high sensitivity, high 3D spatial resolution and, by including precise photon time of flight (TOF) information, a boosted signal-to-noise ratio (SNR). The 4D-PET system incorporates an innovative detector design based on crystal slabs (semi-monolithic) that enables accurate 3D photon impact positioning (including photon Depth of Interaction (DOI) measurement), while providing a precise determination of the photon arrival time to the detector. The detector includes a novel readout system that reduces the number of detector signals in a ratio of 4:1 thus, alleviating complexity and cost. The analog output signals are fed to the TOFPET2 ASIC (PETsys) for scalability purposes. The present manuscript reports the evaluation of the 4D-PET detector, achieving best values 3D resolution values of <1.6 mm (pixelated axis), 2.7±0.5 mm (monolithic axis) and 3.4±1.1 (DOI axis) mm; 359 ± 7 ps coincidence time resolution (CTR); 10.2±1.5 % energy resolution; and sensitivity of 16.2% at the center of the scanner (simulated). Moreover, a comprehensive description of the 4D-PET architecture (that includes 320 detectors), some pictures of its mechanical assembly, and simulations on the expected image quality are provided. es_ES
dc.description.sponsorship This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (Grant Agreement No. 695536). This work was supported in part by the Spanish Government Grants Generalitat Valenciana, APOSTD/2019/086 and APOSTD/2020/139.We thank financial support from Generalitat Valenciana through the program Equipamiento e Infraestructuras FEDER 2021-22 IDIFEDER/2021/004 es_ES
dc.language Inglés es_ES
dc.publisher Walter de Gruyter GmbH es_ES
dc.relation.ispartof Bio-Algorithms and Medical-Systems es_ES
dc.rights Reconocimiento - Compartir igual (by-sa) es_ES
dc.subject Positron Emission Tomography (PET) es_ES
dc.subject Brain PET es_ES
dc.subject Organ-specific PET es_ES
dc.subject Depth-of-Interaction (DOI) es_ES
dc.subject Time-of-flight (TOF) es_ES
dc.subject Semi-monolithic scintillator es_ES
dc.subject Silicon Photomultiplier (SiPM) es_ES
dc.subject Application-specific-integrated-circuit (ASIC) es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title A new brain dedicated PET scanner with 4D detector information es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.2478/bioal-2022-0083 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/695536/EU es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Generalitat Valenciana//IDIFEDER%2F2021%2F004//TERAPIA Y MONITORIZACIÓN NEUROLÓGICA CON TÉCNICAS FÍSICAS MÚLTIPLES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//APOSTD%2F2019%2F086/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//APOSTD%2F2020%2F139/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros de Telecomunicación - Escola Tècnica Superior d'Enginyers de Telecomunicació es_ES
dc.description.bibliographicCitation González-Montoro, A.; Barbera Ballester, J.; Sanchez-Gonzalo, D.; Mondejar, Á.; Freire-López-Fando, M.; Díaz González, K.; Lucero-Ruiz, A.... (2022). A new brain dedicated PET scanner with 4D detector information. Bio-Algorithms and Medical-Systems. 18(1):107-119. https://doi.org/10.2478/bioal-2022-0083 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.2478/bioal-2022-0083 es_ES
dc.description.upvformatpinicio 107 es_ES
dc.description.upvformatpfin 119 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 18 es_ES
dc.description.issue 1 es_ES
dc.relation.pasarela S\483008 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder European Research Council es_ES
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