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dc.contributor.author | Viñals, Clara | es_ES |
dc.contributor.author | Beneyto, Aleix | es_ES |
dc.contributor.author | Martín-SanJosé, Juan-Fernando | es_ES |
dc.contributor.author | Furió-Novejarque, Clara | es_ES |
dc.contributor.author | Hirata-Bertachi, Arthur | es_ES |
dc.contributor.author | Bondía Company, Jorge | es_ES |
dc.contributor.author | Vehí, Josep | es_ES |
dc.contributor.author | Conget, Ignacio | es_ES |
dc.contributor.author | Giménez, Marga | es_ES |
dc.date.accessioned | 2023-09-13T18:00:34Z | |
dc.date.available | 2023-09-13T18:00:34Z | |
dc.date.issued | 2021-01 | es_ES |
dc.identifier.issn | 0021-972X | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/196326 | |
dc.description.abstract | [EN] Objective: To evaluate the safety and performance of a new multivariable closed-loop (MCL) glucose controller with automatic carbohydrate recommendation during and after unannounced and announced exercise in adults with type 1 diabetes (T1D). Research design and methods: A randomized, 3-arm, crossover clinical trial was conducted. Participants completed a heavy aerobic exercise session including three 15-minute sets on a cycle ergometer with 5 minutes rest in between. In a randomly determined order, we compared MCL control with unannounced (CLNA) and announced (CLA) exercise to open-loop therapy (OL). Adults with T1D, insulin pump users, and those with hemoglobin (Hb)A1c between 6.0% and 8.5% were eligible. We investigated glucose control during and 3 hours after exercise. Results: Ten participants (aged 40.8 +/- 7.0 years; HbA1c of 7.3 +/- 0.8%) participated. The use of the MCL in both closed-loop arms decreased the time spent <70 mg/dL of sensor glucose (0.0%, [0.0-16.8] and 0.0%, [0.0-19.2] vs 16.2%, [0.0-26.0], (%, [percentile 10-90]) CLNA and CLA vs OL respectively; P = 0.047, P = 0.063) and the number of hypoglycemic events when compared with OL (CLNA 4 and CLA 3 vs OL 8; P = 0.218, P = 0.250). The use of the MCL system increased the proportion of time within 70 to 180 mg/dL (87.8%, [51.1-100] and 91.9%, [58.7-100] vs 81.1%, [65.4-87.0], (%, [percentile 10-90]) CLNA and CLA vs OL respectively; P = 0.227, P = 0.039). This was achieved with the administration of similar doses of insulin and a reduced amount of carbohydrates. Conclusions: The MCL with automatic carbohydrate recommendation performed well and was safe during and after both unannounced and announced exercise, maintaining glucose mostly within the target range and reducing the risk of hypoglycemia despite a reduced amount of carbohydrate intake. | es_ES |
dc.description.sponsorship | This work has been partially funded by the Spanish Government under grants DPI2016-78831-C2-1-R, DPI2016-78831-C2-2-R, and FPU0244 2015; by the EU through FEDER funds; by the National Counsel of Technological and Scientific Development, CNPq-Brazil 207688/2014-1; and by the Government of Catalonia under 2017SGR1551. C.V. is the recipient of a grant from the Hospital Clinic i Universitari of Barcelona ("Premi Fi de Residencia 2018-2019"). | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | The Endocrine Society | es_ES |
dc.relation.ispartof | The Journal of Clinical Endocrinology & Metabolism | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Artificial pancreas | es_ES |
dc.subject | Type 1 diabetes | es_ES |
dc.subject | Exercise | es_ES |
dc.subject | Closed-loop control | es_ES |
dc.subject | Hypoglycemia prevention and exercise | es_ES |
dc.subject.classification | INGENIERIA DE SISTEMAS Y AUTOMATICA | es_ES |
dc.title | Artificial Pancreas With Carbohydrate Suggestion Performance for Unannounced and Announced Exercise in Type 1 Diabetes | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1210/clinem/dgaa562 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI//DPI2016-78831-C2-1-R//SOLUCIONES PARA LA MEJORA DE LA EFICIENCIA Y SEGURIDAD DEL PÁNCREAS ARTIFICIAL MEDIANTE ARQUITECTURAS DE CONTROL MULTIVARIABLE TOLERANTES A FALLOS/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/CNPq//207688%2F2014-1/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GC//2017SGR1551/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MECD//FPU15%2F00244//FPU15/00244/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//DPI2016-78831-C2-2-R//Soluciones para la mejora de la eficiencia y seguridad del pancreas artificial mediante arquitecturas de control multivariable tolerantes a fallos/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/Hospital Clínic de Barcelona//Premi Fi de Residencia 2018-2019/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials | es_ES |
dc.description.bibliographicCitation | Viñals, C.; Beneyto, A.; Martín-Sanjosé, J.; Furió-Novejarque, C.; Hirata-Bertachi, A.; Bondía Company, J.; Vehí, J.... (2021). Artificial Pancreas With Carbohydrate Suggestion Performance for Unannounced and Announced Exercise in Type 1 Diabetes. The Journal of Clinical Endocrinology & Metabolism. 106(1):55-63. https://doi.org/10.1210/clinem/dgaa562 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1210/clinem/dgaa562 | es_ES |
dc.description.upvformatpinicio | 55 | es_ES |
dc.description.upvformatpfin | 63 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 106 | es_ES |
dc.description.issue | 1 | es_ES |
dc.identifier.pmid | 32852548 | es_ES |
dc.relation.pasarela | S\453381 | es_ES |
dc.contributor.funder | Generalitat de Catalunya | es_ES |
dc.contributor.funder | Hospital Clínic de Barcelona | es_ES |
dc.contributor.funder | AGENCIA ESTATAL DE INVESTIGACION | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Ministerio de Educación, Cultura y Deporte | es_ES |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad | es_ES |
dc.contributor.funder | Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil | es_ES |