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dc.contributor.author | Beltrán-García, Jesús | es_ES |
dc.contributor.author | Manclus Ciscar, Juan José | es_ES |
dc.contributor.author | García-López, Eva M. | es_ES |
dc.contributor.author | Carbonell, Nieves | es_ES |
dc.contributor.author | Ferreres, José | es_ES |
dc.contributor.author | Rodríguez-Gimillo, María | es_ES |
dc.contributor.author | Garcés, Concepción | es_ES |
dc.contributor.author | Pallardó, Federico V. | es_ES |
dc.contributor.author | García-Giménez, José L. | es_ES |
dc.contributor.author | Montoya, Ángel | es_ES |
dc.contributor.author | Romá-Mateo, Carlos | es_ES |
dc.date.accessioned | 2023-09-21T18:05:03Z | |
dc.date.available | 2023-09-21T18:05:03Z | |
dc.date.issued | 2021-09 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/196903 | |
dc.description.abstract | [EN] Sepsis management remains one of the most important challenges in modern clinical practice. Rapid progression from sepsis to septic shock is practically unpredictable, hence the critical need for sepsis biomarkers that can help clinicians in the management of patients to reduce the proba-bility of a fatal outcome. Circulating nucleoproteins released during the inflammatory response to infection, including neutrophil extracellular traps, nucleosomes, and histones, and nuclear pro-teins like HMGB1, have been proposed as markers of disease progression since they are related to inflammation, oxidative stress, endothelial damage, and impairment of the coagulation response, among other pathological features. The aim of this work was to evaluate the actual potential for decision making/outcome prediction of the most commonly proposed chromatin-related bi-omarkers (i.e., nucleosomes, citrullinated H3, and HMGB1). To do this, we compared different ELISA measuring methods for quantifying plasma nucleoproteins in a cohort of critically ill pa-tients diagnosed with sepsis or septic shock compared to nonseptic patients admitted to the inten-sive care unit (ICU), as well as to healthy subjects. Our results show that all studied biomarkers can be used to monitor sepsis progression, although they vary in their effectiveness to separate sepsis and septic shock patients. Our data suggest that HMGB1/citrullinated H3 determination in plasma is potentially the most promising clinical tool for the monitoring and stratification of septic patients. | es_ES |
dc.description.sponsorship | This activity received funding from the European Institute of Innovation and Technology (EIT). This body of the European Union receives support from the European Union's Horizon 2020 research and innovation program. C.R-M. thanks GVA for starting grant (GV/2018/127) and Spanish Ministry of Science and Innovation for research project (PID2020-119127RA-I00); J.B-G thanks ISCIII, AES2018 for iPFIS fellowship (IFI18/00015) and GVA for APOTI fellowship (APOTIP/2017/012); CG thanks Spanish Ministry of Universities for fellowship FPU18/03969; J.L.G-G and F.V.P thank INCLIVA, GVA and AES2016 and AES2019 (ISCIII) for starting grant (GV/2014/132), project PI16/01036 and PI19/00994 and project DTS17/00132 (co-financed by the ERDF). The project leading to these results has received funding from "la Caixa" Foundation (ID 100010434), under agreement CI18-0009. C.R-M., F.V.P. and A.M. thank Grand Challenges Canada. : We want to particularly acknowledge the patients and the INCLIVA Biobank (PT17/0015/0049; B.000768 ISCIII) integrated in the Valencian Biobanking Network and the Spanish National Biobanks Network for their collaboration. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | MDPI AG | es_ES |
dc.relation.ispartof | International Journal of Molecular Sciences | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Sepsis | es_ES |
dc.subject | Septic shock | es_ES |
dc.subject | Circulating histones | es_ES |
dc.subject | Nucleosomes | es_ES |
dc.subject | HMGB1 | es_ES |
dc.subject | Biomarkers | es_ES |
dc.subject | ELISA | es_ES |
dc.title | Comparative Analysis of Chromatin-Delivered Biomarkers in the Monitoring of Sepsis and Septic Shock: A Pilot Study | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.3390/ijms22189935 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119127RA-I00/ES/CITOTOXICIDAD MEDIADA POR MACROMOLECULAS NUCLEARES: MECANISMOS MOLECULARES Y POTENCIAL PARA EL DESARROLLO DE BIOMARCADORES DE SEPSIS Y CHOQUE SEPTICO/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/U.S. AGENCY FOR INTERNATIONAL DEVELOPMENT (USAID)//0456-03-40//Saving Lives at Birth: HIST-BIRTH. Innovative and rapid point-of-care histone test strips for early diagnosis of sepsis in pregnancy and childbirth./ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//GV%2F2014%2F132/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//GV%2F2018%2F127/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//APOTIP%2F2017%2F012/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII//PI16%2F01036/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII//PI19%2F00994/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII//IFI18%2F00015//iPFIS fellowship/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII//DTS17%2F00132/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/Fundació Bancària Caixa d'Estalvis i Pensions de Barcelona//100010434/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MIU//FPU18%2F03969/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.description.bibliographicCitation | Beltrán-García, J.; Manclus Ciscar, JJ.; García-López, EM.; Carbonell, N.; Ferreres, J.; Rodríguez-Gimillo, M.; Garcés, C.... (2021). Comparative Analysis of Chromatin-Delivered Biomarkers in the Monitoring of Sepsis and Septic Shock: A Pilot Study. International Journal of Molecular Sciences. 22(18):1-15. https://doi.org/10.3390/ijms22189935 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/ijms22189935 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 15 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 22 | es_ES |
dc.description.issue | 18 | es_ES |
dc.identifier.eissn | 1422-0067 | es_ES |
dc.identifier.pmid | 34576097 | es_ES |
dc.identifier.pmcid | PMC8465401 | es_ES |
dc.relation.pasarela | S\445635 | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Ministerio de Universidades | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Instituto de Investigación Sanitaria INCLIVA | es_ES |
dc.contributor.funder | European Institute of Innovation and Technology | es_ES |
dc.contributor.funder | U.S. AGENCY FOR INTERNATIONAL DEVELOPMENT (USAID) | es_ES |
dc.contributor.funder | Fundació Bancària Caixa d'Estalvis i Pensions de Barcelona | es_ES |
dc.subject.ods | 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades | es_ES |