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dc.contributor.author | Gallego Bartolomé, Javier | es_ES |
dc.date.accessioned | 2023-12-21T19:01:58Z | |
dc.date.available | 2023-12-21T19:01:58Z | |
dc.date.issued | 2020-07 | es_ES |
dc.identifier.issn | 0028-646X | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/201043 | |
dc.description.abstract | [EN] DNA methylation is an epigenetic mark that regulates multiple processes, such as gene expression and genome stability. Mutants and pharmacological treatments have been instrumental in the study of this mark in plants, although their genome-wide effect complicates the direct association between changes in methylation and a particular phenotype. A variety of tools that allow locus-specific manipulation of DNA methylation can be used to assess its direct role in specific processes, as well as to create novel epialleles. Recently, new tools that recruit the methylation machinery directly to target loci through programmable DNA-binding proteins have expanded the tool kit available to researchers. This review provides an overview of DNA methylation in plants and discusses the tools that have recently been developed for its manipulation. | es_ES |
dc.description.sponsorship | I would like to thank Drs Steve Jacobsen, Jake Harris, German Martinez, Maria A. Nohales, Miguel Blazquez and David Alabadi, as well as three anonymous reviewers for their critical reading of this manuscript and insightful comments. I would also like to apologize to colleagues whose work is not included in this manuscript due to space limitations. JG-B is funded by a Marie Curie Reintegration grant (MSCA-IF EU project 835599). | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Blackwell Publishing | es_ES |
dc.relation.ispartof | New Phytologist | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Artificial zinc finger proteins | es_ES |
dc.subject | CRISPR SunTag | es_ES |
dc.subject | DNA methylation | es_ES |
dc.subject | RNA-directed DNA methylation | es_ES |
dc.subject | Transcriptional gene silencing | es_ES |
dc.title | DNA methylation in plants: mechanisms and tools for targeted manipulation. | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1111/nph.16529 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/835599/EU | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes | es_ES |
dc.description.bibliographicCitation | Gallego Bartolomé, J. (2020). DNA methylation in plants: mechanisms and tools for targeted manipulation. New Phytologist. 227(1):38-44. https://doi.org/10.1111/nph.16529 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1111/nph.16529 | es_ES |
dc.description.upvformatpinicio | 38 | es_ES |
dc.description.upvformatpfin | 44 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 227 | es_ES |
dc.description.issue | 1 | es_ES |
dc.identifier.pmid | 32159848 | es_ES |
dc.relation.pasarela | S\432875 | es_ES |
dc.contributor.funder | European Commission | es_ES |