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dc.contributor.author | Zezza, Paola | es_ES |
dc.contributor.author | Lucío, María Isabel | es_ES |
dc.contributor.author | Naydenova, Izabela | es_ES |
dc.contributor.author | Bañuls Polo, María-José | es_ES |
dc.contributor.author | Maquieira Catala, Angel | es_ES |
dc.date.accessioned | 2024-01-03T19:03:54Z | |
dc.date.available | 2024-01-03T19:03:54Z | |
dc.date.issued | 2023-09 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/201419 | |
dc.description.abstract | [EN] The role of volume hydrogel holographic gratings as optical transducers in sensor devices for point-of-care applications is increasing due to their ability to be functionalized for achieving enhanced selectivity. The first step in the development of these transducers is the optimization of the holographic recording process. The optimization aims at achieving gratings with reproducible diffraction efficiency, which remains stable after reiterative washings, typically required when working with analytes of a biological nature or several step tests. The recording process of volume phase transmission gratings within Acrylamide/Propargyl Acrylate hydrogel layers reported in this work was successfully performed, and the obtained diffraction gratings were optically characterized. Unslanted volume transmission gratings were recorded in the hydrogel layers diffraction efficiencies; up to 80% were achieved. Additionally, the recorded gratings demonstrated stability in water after multiple washing steps. The hydrogels, after functionalization with oligonucleotide probes, yields a specific hybridization response, recognizing the complementary strand as demonstrated by fluorescence. Analyte-sensitive hydrogel layers with holographic structures are a promising candidate for the next generation of in vitro diagnostic tests. | es_ES |
dc.description.sponsorship | This work was financially supported by the E.U. FEDER, the Spanish Ministry of Science and Innovation (ADBIHOL-PID2019-110713RB-I00/AEI/10.13039/501100011033) and Generalitat Valenciana (PROMETEO/2020/094). M. I. Lucio acknowledges MINECO for her Juan de la Cierva-Incorporacion grants (IJC 2018-035355-I). P. Zezza acknowledges the Generalitat Valenciana for her S. Grisolia grant and the UPV for the mobility grant (BEFPI 2022). Funding was also received from Aid for First Research Projects (PAID-06-22) and the Vice-rectorate for Research of the Universitat Politecnica de Valencia (UPV). Partially funded by the European Space Agency, through PEA4000129503 collaborative project: Wound Healing In Space: Key challenges towards Intelligent and Enabling Sensing platforms. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation.ispartof | Gels | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Holographic recording | es_ES |
dc.subject | Volume transmission grating | es_ES |
dc.subject | Hydrogel layer | es_ES |
dc.subject | Diffraction efficiency | es_ES |
dc.subject | Biosensor | es_ES |
dc.subject.classification | QUIMICA ANALITICA | es_ES |
dc.title | Holographic Recording of Unslanted Volume Transmission Gratings in Acrylamide/Propargyl Acrylate Hydrogel Layers: Towards Nucleic Acids Biosensing | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.3390/gels9090710 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110713RB-I00/ES/HACIA EL BIOSENSADO HOLOGRAFICO AVANZADO/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GENERALITAT VALENCIANA//PROMETEO%2F2020%2F094//HOLOGRAFÍA. UNA VIA PARA AFRONTAR NUEVOS RETOS EN BIOSENSADO/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/UPV//PAID-06-22//Erradicación del riesgo de obstrucción de drenajes por arrastre de mobiliario urbano y vehículos por inundación (ERODAMUVI)/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ESA//PEA4000129503/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//IJC 2018-035355-I/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural | es_ES |
dc.description.bibliographicCitation | Zezza, P.; Lucío, MI.; Naydenova, I.; Bañuls Polo, M.; Maquieira Catala, A. (2023). Holographic Recording of Unslanted Volume Transmission Gratings in Acrylamide/Propargyl Acrylate Hydrogel Layers: Towards Nucleic Acids Biosensing. Gels. 9(9). https://doi.org/10.3390/gels9090710 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/gels9090710 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 9 | es_ES |
dc.description.issue | 9 | es_ES |
dc.identifier.eissn | 2310-2861 | es_ES |
dc.identifier.pmid | 37754391 | es_ES |
dc.identifier.pmcid | PMC10528564 | es_ES |
dc.relation.pasarela | S\498643 | es_ES |
dc.contributor.funder | European Space Agency | es_ES |
dc.contributor.funder | GENERALITAT VALENCIANA | es_ES |
dc.contributor.funder | AGENCIA ESTATAL DE INVESTIGACION | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Universitat Politècnica de València | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |