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dc.contributor.author | Pérez-Cervera, Laura | es_ES |
dc.contributor.author | De Santis, Silvia | es_ES |
dc.contributor.author | Marcos, Encarni | es_ES |
dc.contributor.author | Ghorbanzad-Ghaziany, Zahra | es_ES |
dc.contributor.author | Trouvé-Carpena, Alejandro | es_ES |
dc.contributor.author | Selim, Mohamed Kotb | es_ES |
dc.contributor.author | Pérez-Ramírez, Úrsula | es_ES |
dc.contributor.author | Pfarr, Simone | es_ES |
dc.contributor.author | Bach, Patrick | es_ES |
dc.contributor.author | P Halli | es_ES |
dc.contributor.author | Kiefer, Falk | es_ES |
dc.contributor.author | Moratal, David | es_ES |
dc.contributor.author | Kirsch, Peter | es_ES |
dc.contributor.author | Sommer, Wolfgang H. | es_ES |
dc.contributor.author | Canals, Santiago | es_ES |
dc.date.accessioned | 2024-04-15T18:09:43Z | |
dc.date.available | 2024-04-15T18:09:43Z | |
dc.date.issued | 2023-06-21 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/203517 | |
dc.description.abstract | [EN] IntroductionAlcohol dependence is characterized by a gradual reduction in cognitive control and inflexibility to contingency changes. The neuroadaptations underlying this aberrant behavior are poorly understood. Using an animal model of alcohol use disorders (AUD) and complementing diffusion-weighted (dw)-MRI with quantitative immunohistochemistry and electrophysiological recordings, we provide causal evidence that chronic intermittent alcohol exposure affects the microstructural integrity of the fimbria/fornix, decreasing myelin basic protein content, and reducing the effective communication from the hippocampus (HC) to the prefrontal cortex (PFC). Using a simple quantitative neural network model, we show how disturbed HC-PFC communication may impede the extinction of maladaptive memories, decreasing flexibility. Finally, combining dw-MRI and psychometric data in AUD patients, we discovered an association between the magnitude of microstructural alteration in the fimbria/fornix and the reduction in cognitive flexibility. Overall, these findings highlight the vulnerability of the fimbria/fornix microstructure in AUD and its potential contribution to alcohol pathophysiology.Fimbria vulnerability to alcohol underlies hippocampal-prefrontal cortex dysfunction and correlates with cognitive impairment. | es_ES |
dc.description.sponsorship | The authors acknowledge funding from the European Union Horizon 2020 research and innovation program under Grant Agreement No. 668863 (SyBil-AA), and the Spanish Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación (PID2021-128158NB-C21 [to S.C.] and PID2021-128909NA-I00 [to S.D.S.]) and Programs for Centres of Excellence in R&D Severo Ochoa (CEX2021-001165-S [to S.C. and S.D.S.]), the Spanish Generalitat Valenciana Government (PROMETEO/2019/015 [to SC] and CIDEGENT/2021/015 [to SDS]), the Spanish Ministerio de Sanidad, Servicios Sociales e Igualdad (#2021I082). W.H.S., F.K. and P.K. further acknowledge funding by the Deutsche Forschungs Gesellschaft through the Collaborative research Center grant TRR265 EnCoDe [138]. F.K. and P.K. also acknowledge funding by the Deutsche Forschungs Gesellschaft through the Collaborative Research Center SFB636 (Project D6). Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | BioMed Central Ltd. | es_ES |
dc.relation.ispartof | Acta Neuropathologica Communications | es_ES |
dc.rights | Reconocimiento (by) | es_ES |
dc.subject | Fimbria | es_ES |
dc.subject | Fornix | es_ES |
dc.subject | DTI | es_ES |
dc.subject | Diffusion | es_ES |
dc.subject | White matter | es_ES |
dc.subject | AUD | es_ES |
dc.subject | Alcohol | es_ES |
dc.subject | Prefrontal cortex | es_ES |
dc.subject | Hippocampus | es_ES |
dc.subject | Memory | es_ES |
dc.subject | Flexibility | es_ES |
dc.subject | Cognitive test | es_ES |
dc.subject | TMT | es_ES |
dc.subject.classification | TECNOLOGIA ELECTRONICA | es_ES |
dc.title | Alcohol-induced damage to the fimbria/fornix reduces hippocampal-prefrontal cortex connection during early abstinence | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1186/s40478-023-01597-8 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-128158NB-C21/ES/ACTUALIZACION DE LA BASE DE MEMORIA DEL CEREBRO: PERSPECTIVA EXPERIMENTAL/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-128909NA-I00/ES/TRAYECTORIAS DE ENVEJECIMIENTO PARA BIEN-VEJECER: NUEVAS HERRAMIENTAS PARA CARACTERIZAR DE FORMA NO INVASIVA LA EVOLUCION Y REPARACION DEL CEREBRO/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/668863/EU/Systems Biology of Alcohol Addiction: Modeling and validating disease state networks in human and animal brains for understanding pathophysiolgy, predicting outcomes and improving therapy/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/DFG//TRR265-B08/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEO%2F2019%2F015/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEO%2F2021%2F015/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI//CEX2021-001165-S/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials | es_ES |
dc.description.bibliographicCitation | Pérez-Cervera, L.; De Santis, S.; Marcos, E.; Ghorbanzad-Ghaziany, Z.; Trouvé-Carpena, A.; Selim, MK.; Pérez-Ramírez, Ú.... (2023). Alcohol-induced damage to the fimbria/fornix reduces hippocampal-prefrontal cortex connection during early abstinence. Acta Neuropathologica Communications. 11(1):1-21. https://doi.org/10.1186/s40478-023-01597-8 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1186/s40478-023-01597-8 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 21 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 11 | es_ES |
dc.description.issue | 1 | es_ES |
dc.identifier.eissn | 2051-5960 | es_ES |
dc.identifier.pmid | 37344865 | es_ES |
dc.identifier.pmcid | PMC10286362 | es_ES |
dc.relation.pasarela | S\511317 | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Deutsche Forschungsgemeinschaft | es_ES |
dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
dc.subject.ods | 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades | es_ES |