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Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors

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Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors

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dc.contributor.author Montagut, Yeison es_ES
dc.contributor.author García Narbón, José Vicente es_ES
dc.contributor.author Jiménez Jiménez, Yolanda es_ES
dc.contributor.author March Iborra, Mª Del Carmen es_ES
dc.contributor.author Montoya Baides, Ángel es_ES
dc.contributor.author Arnau Vives, Antonio es_ES
dc.date.accessioned 2013-05-14T11:40:31Z
dc.date.available 2013-05-14T11:40:31Z
dc.date.issued 2011
dc.identifier.issn 1424-8220
dc.identifier.uri http://hdl.handle.net/10251/28829
dc.description.abstract Acoustic wave resonator techniques are widely used in in-liquid biochemical applications. The main challenges remaining are the improvement of sensitivity and limit of detection, as well as multianalysis capabilities and reliability. The sensitivity improvement issue has been addressed by increasing the sensor frequency, using different techniques such as high fundamental frequency quartz crystal microbalances (QCMs), surface generated acoustic waves (SGAWs) and film bulk acoustic resonators (FBARs). However, this sensitivity improvement has not been completely matched in terms of limit of detection. The decrease on frequency stability due to the increase of the phase noise, particularly in oscillators, has made it impossible to increase the resolution. A new concept of sensor characterization at constant frequency has been recently proposed based on the phase/mass sensitivity equation: ¿¿/¿m ¿ -1/m L, where m L is the liquid mass perturbed by the resonator. The validation of the new concept is presented in this article. An immunosensor application for the detection of a low molecular weight pollutant, the insecticide carbaryl, has been chosen as a validation model. © 2011 by the authors; licensee MDPI, Basel, Switzerland. es_ES
dc.description.sponsorship The authors are grateful to the Spanish Ministry of Science and Technology the financial support to this research under contract reference AGL2009-13511, and to the company Advanced Wave Sensors S.L. (www.awsensors.com) for the help provided in the development of some parts of this work. en_EN
dc.language Inglés es_ES
dc.publisher MDPI es_ES
dc.relation.ispartof Sensors es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Acoustic biosensors es_ES
dc.subject High fundamental frequency QCM es_ES
dc.subject High resolution es_ES
dc.subject Microbalance es_ES
dc.subject Phase characterization es_ES
dc.subject Sensitivity es_ES
dc.subject Acoustics es_ES
dc.subject Article es_ES
dc.subject Genetic procedures es_ES
dc.subject Instrumentation es_ES
dc.subject Methodology es_ES
dc.subject Quartz crystal microbalance es_ES
dc.subject Biosensing Techniques es_ES
dc.subject Quartz Crystal Microbalance Techniques es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3390/s110504702
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//AGL2009-13511/ES/Inmunosensor Piezoelectrico De Alta Frecuencia Para La Deteccion De Bisfenol-A Y Ftalatos En Alimentos Envasados/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà es_ES
dc.description.bibliographicCitation Montagut, Y.; García Narbón, JV.; Jiménez Jiménez, Y.; March Iborra, MDC.; Montoya Baides, Á.; Arnau Vives, A. (2011). Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors. Sensors. 11(5):4702-4720. https://doi.org/10.3390/s110504702 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.3390/s110504702 es_ES
dc.description.upvformatpinicio 4702 es_ES
dc.description.upvformatpfin 4720 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 11 es_ES
dc.description.issue 5 es_ES
dc.relation.senia 41500
dc.identifier.pmid 22163871 en_EN
dc.identifier.pmcid PMC3231406 en_EN
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
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