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Nerves projecting from the intrinsic cardiac ganglia of the pulmonary veins modulate sinoatrial node pacemaker function

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Nerves projecting from the intrinsic cardiac ganglia of the pulmonary veins modulate sinoatrial node pacemaker function

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dc.contributor.author Zarzoso Muñoz, Manuel es_ES
dc.contributor.author Rysevaite, Kristina es_ES
dc.contributor.author Milstein, Michelle L. es_ES
dc.contributor.author Calvo Saiz, Conrado Javier es_ES
dc.contributor.author Kean, Adam C. es_ES
dc.contributor.author Atienza Fernández, Felipe es_ES
dc.contributor.author Pauza, Dainius Haroldas es_ES
dc.contributor.author Jalife, José es_ES
dc.contributor.author Noujaim, Sami F. es_ES
dc.date.accessioned 2015-06-16T12:39:11Z
dc.date.issued 2013-06-28
dc.identifier.issn 0008-6363
dc.identifier.uri http://hdl.handle.net/10251/51792
dc.description.abstract Rationale: Autonomic nerves from sinoatrial node (SAN) ganglia are known to regulate SAN function. However, it is unclear whether remote pulmonary vein ganglia (PVG) also modulate SAN pacemaker rhythm. Objective: To investigate whether in the mouse heart PVG modulate SAN function. Methods and Results: In hearts from 45 C57BL and 7 Connexin40+/GFP mice, we used tyrosine-hydroxylase (TH) and choline-acetyltransferase (ChAT) immunofluorescence labeling to characterize adrenergic and cholinergic elements, repectively, within the PVG and SAN. PVG project postganglionic nerves to the SAN. TH and ChAT stained nerves, enter the SAN as an extensive, dense mesh-like neural network. Neurons in PVG are biphenotypic, containing ChAT and TH positive neurons. In Langendorff-perfused hearts, we compared effects of electrical stimulation of PVG, posterior (PRCVG) and anterior right vena cava ganglia (ARCVG) using 200-2000 ms trains of pulses (300μs, 0.2-0.6mA, 200Hz). Sympathetic and/or parasympathetic blockade was achieved using 0.5μM propranolol and 1μM atropine, respectively. Epicardial optical mapping of SAN activation was performed before, during and after ganglion stimulation. PVG stimulation increased the P-P interval by 36±9%; PRCVG stimulation increased the P-P interval by 42±11%. ARCVG stimulation produced no change. Propranolol perfusion increased the PVG stimulation effect to 43±13%. Atropine caused a 5±6% decrease. In optical mapping experiments of whole hearts and isolated atrial preparations, PVG stimulation shifted the origin of SAN discharges to varying locations. Conclusions: PVG contain cholinergic, adrenergic and biphenotipic neurons whose axons project across the right atrium to richly innervate the SAN region and contribute significantly to regulation of SAN function. es_ES
dc.language Inglés es_ES
dc.publisher Oxford University Press (OUP): Policy B es_ES
dc.relation.ispartof Cardiovascular Research es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Intrinsic cardiac ganglia es_ES
dc.subject cardiac arrhythmias es_ES
dc.subject optical mapping es_ES
dc.subject sinoatrial node es_ES
dc.subject pulmonary veins es_ES
dc.subject mouse heart es_ES
dc.title Nerves projecting from the intrinsic cardiac ganglia of the pulmonary veins modulate sinoatrial node pacemaker function es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1093/cvr/cvt081
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Aplicaciones de las Tecnologías de la Información - Institut Universitari d'Aplicacions de les Tecnologies de la Informació es_ES
dc.description.bibliographicCitation Zarzoso Muñoz, M.; Rysevaite, K.; Milstein, ML.; Calvo Saiz, CJ.; Kean, AC.; Atienza Fernández, F.; Pauza, DH.... (2013). Nerves projecting from the intrinsic cardiac ganglia of the pulmonary veins modulate sinoatrial node pacemaker function. Cardiovascular Research. 566-575. doi:10.1093/cvr/cvt081 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1093/cvr/cvt081 es_ES
dc.description.upvformatpinicio 566 es_ES
dc.description.upvformatpfin 575 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.relation.senia 258451
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