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Biopartitioning micellar chromatography to pedict mutagenicity of aromatic amines

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Biopartitioning micellar chromatography to pedict mutagenicity of aromatic amines

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dc.contributor.author Torres-Cartas, Sagrario es_ES
dc.contributor.author Martín-Biosca, Y. es_ES
dc.contributor.author Villanueva-Camañas, R. M. es_ES
dc.contributor.author Sagrado, S. es_ES
dc.contributor.author Medina-Hernández, M. J. es_ES
dc.date.accessioned 2015-09-17T14:11:17Z
dc.date.available 2015-09-17T14:11:17Z
dc.date.issued 2007
dc.identifier.issn 0223-5234
dc.identifier.uri http://hdl.handle.net/10251/54765
dc.description.abstract [EN] Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry and their mutagenic capacity. Biopartitioning micellar chromatography (BMC), a mode of micellar liquid chromatography that uses micellar mobile phases of Brij35 in adequate experimental conditions, has demonstrated to be useful in mimicking the drug partitioning process into biological systems. In this paper, the usefulness of BMC for predicting mutagenicity of aromatic amines is demonstrated. A multiple linear regression (MLR) model based on BMC retention data is proposed and compared with other ones reported in bibliography. The proposed model present better or similar descriptive and predictive capability. es_ES
dc.description.sponsorship The authors acknowledge the Spanish Ministry of Science and Technology (MCYT) and the European Regional Development Fund (ERDF) for the financial support (Project SA2005-01435).
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof European Journal of Medicinal Chemistry es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Mutagenicity es_ES
dc.subject Biopartitioning micellar chromatography es_ES
dc.subject Aromatic amines es_ES
dc.subject Quantitative retentione-activity relationships es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Biopartitioning micellar chromatography to pedict mutagenicity of aromatic amines es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.ejmech.2007.02.022
dc.relation.projectID info:eu-repo/grantAgreement/MEC//SAF2005-01435/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Investigación para la Gestión Integral de Zonas Costeras - Institut d'Investigació per a la Gestió Integral de Zones Costaneres es_ES
dc.description.bibliographicCitation Torres-Cartas, S.; Martín-Biosca, Y.; Villanueva-Camañas, RM.; Sagrado, S.; Medina-Hernández, MJ. (2007). Biopartitioning micellar chromatography to pedict mutagenicity of aromatic amines. European Journal of Medicinal Chemistry. 42(11-12):1396-1402. https://doi.org/10.1016/j.ejmech.2007.02.022 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.ejmech.2007.02.022 es_ES
dc.description.upvformatpinicio 1396 es_ES
dc.description.upvformatpfin 1402 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 42 es_ES
dc.description.issue 11-12 es_ES
dc.relation.senia 31414
dc.identifier.pmid 17482318
dc.contributor.funder Ministerio de Educación y Ciencia es_ES


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