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Biopartitioning micellar chromatoraphy to predict blood to lung, blood to liver, blood to fat and blood to skin partition coefficients of drugs

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Biopartitioning micellar chromatoraphy to predict blood to lung, blood to liver, blood to fat and blood to skin partition coefficients of drugs

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dc.contributor.author Martin-Biosca, Y. es_ES
dc.contributor.author Torres-Cartas, Sagrario es_ES
dc.contributor.author Villanueva-Camanas, R. M. es_ES
dc.contributor.author Sagrado, S. es_ES
dc.contributor.author Medina-Hernandez, M. J. es_ES
dc.date.accessioned 2015-09-17T14:12:27Z
dc.date.available 2015-09-17T14:12:27Z
dc.date.issued 2009-01-26
dc.identifier.issn 0003-2670
dc.identifier.uri http://hdl.handle.net/10251/54766
dc.description.abstract [EN] Biopartitioning micellar chromatography (BMC), a mode of micellar liquid chromatography that uses micellar mobile phases of Brij35 in adequate experimental conditions, has demonstrated to be useful in mimicking the drug partitioning process into biological systems. In this paper, the usefulness of BMC for predicting the partition coefficients from blood to lung, blood to liver. blood to fat and blood to skin is demonstrated. PLS2 and multiple linear regression (MLR) models based on BMC retention data are proposed and compared with other ones reported in bibliography. The proposed models present better or similar descriptive and predictive capability. (C) 2008 Elsevier B.V. All rights reserved. es_ES
dc.description.sponsorship The authors acknowledge the Spanish Ministry of Science and Technology (MCYT) and the European Regional Development Fund (ERDF) for the financial support (Project SA2005-01435).
dc.language Inglés es_ES
dc.publisher Elsevier Masson es_ES
dc.relation.ispartof Analytica Chimica Acta es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Partition coefficients es_ES
dc.subject Blood to lung es_ES
dc.subject Blood to fat es_ES
dc.subject Blood to liver es_ES
dc.subject Blood to skin es_ES
dc.subject Biopartitioning micellar chromatography es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Biopartitioning micellar chromatoraphy to predict blood to lung, blood to liver, blood to fat and blood to skin partition coefficients of drugs es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.aca.2008.11.004
dc.relation.projectID info:eu-repo/grantAgreement/MEC//SAF2005-01435/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Investigación para la Gestión Integral de Zonas Costeras - Institut d'Investigació per a la Gestió Integral de Zones Costaneres es_ES
dc.description.bibliographicCitation Martin-Biosca, Y.; Torres-Cartas, S.; Villanueva-Camanas, RM.; Sagrado, S.; Medina-Hernandez, MJ. (2009). Biopartitioning micellar chromatoraphy to predict blood to lung, blood to liver, blood to fat and blood to skin partition coefficients of drugs. Analytica Chimica Acta. 632(2):296-303. https://doi.org/10.1016/j.aca.2008.11.004 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.aca.2008.11.004 es_ES
dc.description.upvformatpinicio 296 es_ES
dc.description.upvformatpfin 303 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 632 es_ES
dc.description.issue 2 es_ES
dc.relation.senia 34314
dc.identifier.pmid 19110108
dc.contributor.funder Ministerio de Educación y Ciencia es_ES


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