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Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis

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Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis

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dc.contributor.author Faus, I. es_ES
dc.contributor.author Zabalza Ostos, Ana Mª es_ES
dc.contributor.author Santiago, J. es_ES
dc.contributor.author González Nebauer, Sergio es_ES
dc.contributor.author Royuela, M. es_ES
dc.contributor.author Serrano, R. es_ES
dc.contributor.author Gadea, J. es_ES
dc.date.accessioned 2016-01-27T08:30:53Z
dc.date.available 2016-01-27T08:30:53Z
dc.date.issued 2015-01-21
dc.identifier.issn 1471-2229
dc.identifier.uri http://hdl.handle.net/10251/60217
dc.description.abstract Background: The increased selection pressure of the herbicide glyphosate has played a role in the evolution of glyphosate-resistance in weedy species, an issue that is becoming a threat to global agriculture. The molecular components involved in the cellular toxicity response to this herbicide at the expression level are still unidentified. Results: In this study, we identify the protein kinase GCN2 as a cellular component that fosters the action of glyphosate in the model plant Arabidopsis thaliana. Comparative studies using wild-type and gcn2 knock-out mutant seedlings show that the molecular programme that the plant deploys after the treatment with the herbicide, is compromised in gcn2. Moreover, gcn2 adult plants show a lower inhibition of photosynthesis, and both seedlings and adult gcn2 plants accumulate less shikimic acid than wild-type after treatment with glyphosate. Conclusions: These results points to an unknown GCN2-dependent factor involved in the cascade of events triggered by glyphosate in plants. Data suggest either that the herbicide does not equally reach the target-enzyme in a gcn2 background, or that a decreased flux in the shikimate pathway in a gcn2 plants minimize the impact of enzyme inhibition. es_ES
dc.description.sponsorship p This work was mainly supported by the Universidad Politecnica de Valencia (PAID2011-16) and the Ministerio Espanol de Ciencia y Tecnologia (BFU2011-22526). The work was partially supported through a grant from the Ministerio Espanol de Ciencia y Tecnologia (AGL-2010-18621). en_EN
dc.language Inglés es_ES
dc.publisher BioMed Central es_ES
dc.relation.ispartof BMC Plant Biology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Glyphosate es_ES
dc.subject Gcn2 es_ES
dc.subject Transcriptomic es_ES
dc.subject Shikimate es_ES
dc.subject Translation es_ES
dc.subject Herbicide es_ES
dc.subject.classification FISIOLOGIA VEGETAL es_ES
dc.title Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1186/s12870-014-0378-0
dc.relation.projectID info:eu-repo/grantAgreement/UPV//PAID-2011-16/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//BFU2011-22526/ES/NUEVOS MECANISMOS DE TRANSMISION DE SEÑALES DURANTE EL METABOLISMO DE GLUCOSA Y LA ACIDIFICACION INTRACELULAR: AMPLIANDO LAS FUNCIONES DE LA PROTEINA FOSFATASA 1 Y LA PROTEINA/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Producción Vegetal - Departament de Producció Vegetal es_ES
dc.description.bibliographicCitation Faus, I.; Zabalza Ostos, AM.; Santiago, J.; González Nebauer, S.; Royuela, M.; Serrano, R.; Gadea, J. (2015). Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis. BMC Plant Biology. 15(14). https://doi.org/10.1186/s12870-014-0378-0 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1186/s12870-014-0378-0 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 15 es_ES
dc.description.issue 14 es_ES
dc.relation.senia 280788 es_ES
dc.identifier.pmid 25603772 en_EN
dc.identifier.pmcid PMC4312595 en_EN
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
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