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Magnetic resonance spectroscopy and imaging on fresh human brain tumor biopsies at microscopic resolution

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Magnetic resonance spectroscopy and imaging on fresh human brain tumor biopsies at microscopic resolution

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dc.contributor.author Martínez-Bisbal, M.Carmen es_ES
dc.contributor.author Martínez-Granados, Beatriz es_ES
dc.contributor.author Rovira, Vicente es_ES
dc.contributor.author Celda, Bernardo es_ES
dc.contributor.author Esteve, Vicent es_ES
dc.date.accessioned 2016-04-25T08:24:10Z
dc.date.available 2016-04-25T08:24:10Z
dc.date.issued 2015-09
dc.identifier.issn 1618-2642
dc.identifier.uri http://hdl.handle.net/10251/62871
dc.description.abstract [EN] The metabolic compn. and concn. knowledge provided by magnetic resonance spectroscopy (MRS) liq. and high-resoln. magic angle spinning spectroscopy (HR-MAS) has a relevant impact in clin. practice during magnetic resonance imaging (MRI) monitoring of human tumors. In addn., the combination of morphol. and chem. information by MRI and MRS has been particularly useful for diagnosis and prognosis of tumor evolution. MRI spatial resoln. reachable in human beings is limited for safety reasons and the demanding necessary conditions are only applicable on exptl. model animals. Nevertheless, MRS and MRI can be performed on human biopsies at high spatial resoln., enough to allow a direct correlation between the chem. information and the histol. features obsd. in such biopsies. Although HR-MAS is nowadays a well-established technique for spectroscopic anal. of tumor biopsies, with this approach just a mean metabolic profile of the whole sample can be obtained and thus the high histol. heterogeneity of some important tumors is mostly neglected. The value of metabolic HR-MAS data strongly depends on a wide statistical anal. and usually the microanatomical rationale for the correlation between histol. and spectroscopy is lost. We present here a different approach for the combined use of MRI and MRS on fresh human brain tumor biopsies with native contrast. This approach has been designed to achieve high spatial (18 × 18 × 50 m) and spectral (0.031 L) resoln. in order to obtain as much spatially detailed morphol. and metabolical information as possible without any previous treatment that can alter the sample. The preservation of native tissue conditions can provide information that can be translated to in vivo studies and addnl. opens the possibility of performing other techniques to obtain complementary information from the same sample. es_ES
dc.description.sponsorship The authors acknowledge the SCSIE-University of Valencia Microscopy Service for the histological preparations. They also acknowledge financial support from the Spanish Government project SAF2007-6547, the Generalitat Valenciana project GVACOMP2009-303, and the E.U.s VI Framework Program via the project "Web accessible MR decision support system for brain tumor diagnosis and prognosis, incorporating in vivo and ex vivo genomic and metabolomic data" (FP6-2002-LSH 503094). en_EN
dc.language Inglés es_ES
dc.publisher Springer Verlag (Germany) es_ES
dc.relation.ispartof Analytical and Bioanalytical Chemistry es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Magnetic resonance imaging es_ES
dc.subject Magnetic resonance spectroscopy es_ES
dc.subject Magnetic resonance microscopy es_ES
dc.subject High-resolution magic angle spinning spectroscopy (HR-MAS) es_ES
dc.subject Biopsy es_ES
dc.subject Human brain tumor es_ES
dc.subject Fresh tissue es_ES
dc.subject Glioblastoma es_ES
dc.title Magnetic resonance spectroscopy and imaging on fresh human brain tumor biopsies at microscopic resolution es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s00216-015-8847-3
dc.relation.projectID info:eu-repo/grantAgreement/MEC//SAF2007-65473/ES/BIOMARCADORES MEDIANTE ANALISIS COMBINADO TRANSCRIPTOMICA, PROTEOMICA Y METABOLOMICA. APLICACION AL DIAGNOSTICO, PRONOSTICO Y SELECCION DE TRATAMIENTO EN NEOPLASIAS DE CEREBRO Y MAMA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/503094/EU/WEB ACCESSIBLE MR DECISION SUPPORT SYSTEM FOR BRAIN TUMOUR DIAGNOSIS AND PROGNOSIS, INCORPORATING IN VIVO AND EX VIVO GENOMIC AND METABOLIMIC DATA/ETUMOUR/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//ACOMP%2F2009%2F303/ es_ES
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Martínez-Bisbal, M.; Martínez-Granados, B.; Rovira, V.; Celda, B.; Esteve, V. (2015). Magnetic resonance spectroscopy and imaging on fresh human brain tumor biopsies at microscopic resolution. Analytical and Bioanalytical Chemistry. 407(22):6771-6780. https://doi.org/10.1007/s00216-015-8847-3 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1007/s00216-015-8847-3 es_ES
dc.description.upvformatpinicio 6771 es_ES
dc.description.upvformatpfin 6780 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 407 es_ES
dc.description.issue 22 es_ES
dc.relation.senia 300087 es_ES
dc.identifier.pmid 26123440
dc.contributor.funder Ministerio de Educación y Ciencia
dc.contributor.funder Generalitat Valenciana
dc.contributor.funder European Commission
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