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Polycaprolactone membranes reinforced by toughened sol-gel produced silica networks

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Polycaprolactone membranes reinforced by toughened sol-gel produced silica networks

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Nombre: Sara Trujillo;CLARA ...
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dc.contributor.author Trujillo, Sara es_ES
dc.contributor.author Plazas Bonilla, Clara Eugenia es_ES
dc.contributor.author Santos, Marta Sofía es_ES
dc.contributor.author Matos, Joana M. es_ES
dc.contributor.author Gamboa Martínez, Tatiana Carolina es_ES
dc.contributor.author Perilla, Jairo Ernesto es_ES
dc.contributor.author Mano, Joao F. es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.date.accessioned 2016-05-17T07:40:28Z
dc.date.available 2016-05-17T07:40:28Z
dc.date.issued 2014-07
dc.identifier.issn 0928-0707
dc.identifier.uri http://hdl.handle.net/10251/64192
dc.description.abstract The aim of this work is to develop polycaprolactone based porous materials with improved mechanical performance to be used in bone repair. The hybrid membranes consist in a polymeric porous material in which the pore walls are coated by a silica thin layer. Silica coating increases membrane stiffness with respect to pure polymer but in addition filling the pores of the polymer with a silica phase improves bioactivity due to the delivery of silica ions in the neighborhood of the material in vivo. Nevertheless silica network, even that produced by sol-gel, might be too stiff and brittle what is not desirable for its performance as a coating. In this work we produced a toughened silica coating adding chitosan and 3-glycidoxypropyltrimethoxysilane (GPTMS) to the precursor solution looking for having polymer chains linked by covalent bonding to the silica network. Hybrid polymer-silica coating was produced by in situ sol-gel reaction using Tetraethyl orthosilicate (TEOS), GPTMS and chitosan. Chemical reaction between amine groups of chitosan chains and epoxy groups of GPTMS allowed covalent bonding of polymer chains to the silica network. Physical properties of the hybrid membranes were characterized and cell attachment of MC3T3-E1 pre-osteoblastic cells on the surface of these supports was assessed. es_ES
dc.description.sponsorship CEPB acknowledges the economic support of COOPEN agreement in the progress of the present work. JFM acknowledges the support from Fundacao para a Ciencia e Tecnologia through project PTDC/FIS/115048/2009. JLGR acknowledges the support of the Spanish Ministry of Education through project No. MAT2010-21611-C03-01. CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. Authors want to thank the technical support of the Universitat Politecnica de Valencia's Microscopy Service. en_EN
dc.language Inglés es_ES
dc.publisher Springer Verlag es_ES
dc.relation.ispartof Journal of Sol-Gel Science and Technology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Polycaprolactone es_ES
dc.subject Chitosan es_ES
dc.subject Sol-gel es_ES
dc.subject Silica coating es_ES
dc.subject Biodegradable biomaterials es_ES
dc.subject Bone tissue engineering es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Polycaprolactone membranes reinforced by toughened sol-gel produced silica networks es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s10971-014-3342-4
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//MAT2010-21611-C03-01/ES/MATERIALES BIOESTABLES Y BIOREABSORBIBLES A LARGO PLAZO COMO SOPORTES MACROPOROSOS PARA LA REGENERACION DEL CARTILAGO ARTICULAR/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/FCT/5876-PPCDTI/115048/PT/SupraRelax: Molecular mobility of biodegradable polymer in ultra-confined supramolecular organized geometries/
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Trujillo, S.; Plazas Bonilla, CE.; Santos, MS.; Matos, JM.; Gamboa Martínez, TC.; Perilla, JE.; Mano, JF.... (2014). Polycaprolactone membranes reinforced by toughened sol-gel produced silica networks. Journal of Sol-Gel Science and Technology. 71(1):136-146. https://doi.org/10.1007/s10971-014-3342-4 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1007/s10971-014-3342-4 es_ES
dc.description.upvformatpinicio 136 es_ES
dc.description.upvformatpfin 146 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 71 es_ES
dc.description.issue 1 es_ES
dc.relation.senia 284986 es_ES
dc.identifier.eissn 1573-4846
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Fundação para a Ciência e a Tecnologia, Portugal
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