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Three-dimensional cardiac computational modelling: methods, features and applications

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Three-dimensional cardiac computational modelling: methods, features and applications

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dc.contributor.author López Pérez, Alejandro Daniel es_ES
dc.contributor.author Sebastián Aguilar, Rafael es_ES
dc.contributor.author Ferrero De Loma-Osorio, José María es_ES
dc.date.accessioned 2016-05-30T10:39:43Z
dc.date.available 2016-05-30T10:39:43Z
dc.date.issued 2015-04-17
dc.identifier.issn 1475-925X
dc.identifier.uri http://hdl.handle.net/10251/64928
dc.description.abstract [EN] The combination of computational models and biophysical simulations can help to interpret an array of experimental data and contribute to the understanding, diagnosis and treatment of complex diseases such as cardiac arrhythmias. For this reason, three-dimensional (3D) cardiac computational modelling is currently a rising field of research. The advance of medical imaging technology over the last decades has allowed the evolution from generic to patient-specific 3D cardiac models that faithfully represent the anatomy and different cardiac features of a given alive subject. Here we analyse sixty representative 3D cardiac computational models developed and published during the last fifty years, describing their information sources, features, development methods and online availability. This paper also reviews the necessary components to build a 3D computational model of the heart aimed at biophysical simulation, paying especial attention to cardiac electrophysiology (EP), and the existing approaches to incorporate those components. We assess the challenges associated to the different steps of the building process, from the processing of raw clinical or biological data to the final application, including image segmentation, inclusion of substructures and meshing among others. We briefly outline the personalisation approaches that are currently available in 3D cardiac computational modelling. Finally, we present examples of several specific applications, mainly related to cardiac EP simulation and model-based image analysis, showing the potential usefulness of 3D cardiac computational modelling into clinical environments as a tool to aid in the prevention, diagnosis and treatment of cardiac diseases. es_ES
dc.description.sponsorship This work was partially supported by the "VI Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica" from the Ministerio de Economia y Competitividad of Spain (TIN2012-37546-C03-01 and TIN2011-28067) and the European Commission (European Regional Development Funds - ERDF - FEDER) and by "eTorso project" (GVA/2013-001404) from the Generalitat Valenciana (Spain). ALP is financially supported by the program "Ayudas para contratos predoctorales para la formacion de doctores" from the Ministerio de Economia y Competitividad of Spain (BES-2013-064089).
dc.language Inglés es_ES
dc.publisher BioMed Central es_ES
dc.relation.ispartof BioMedical Engineering OnLine es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Cardiac modelling es_ES
dc.subject Three-dimensional (3D) modelling es_ES
dc.subject Computational modelling es_ES
dc.subject Fibre orientation es_ES
dc.subject Cardiac conduction system (CCS) es_ES
dc.subject Cardiac image segmentation es_ES
dc.subject Biophysical simulation es_ES
dc.subject Personalisation es_ES
dc.subject Patient-specific modelling es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Three-dimensional cardiac computational modelling: methods, features and applications es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1186/s12938-015-0033-5
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//TIN2012-37546-C03-01/ES/CORAZON HUMANO COMPLETO FISIOLOGICO VIRTUAL: MEJORAS EN EL TRATAMIENTO DE ARRITMIAS CARDIACAS ORIENTADO A PACIENTE/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//TIN2011-28067/ES/SIMULACIONES RAPIDAS DE LA ELECTROFISIOLOGIA DEL CORAZON BASADAS EN SEÑALES E IMAGENES PARA LA PLANIFICACION ASISTIDA POR ORDENADOR DE INTERVENCIONES CLINICAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//GV%2F2013-001404/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BES-2013-064089/ES/BES-2013-064089/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation López Pérez, AD.; Sebastián Aguilar, R.; Ferrero De Loma-Osorio, JM. (2015). Three-dimensional cardiac computational modelling: methods, features and applications. BioMedical Engineering OnLine. 14(35):1-31. https://doi.org/10.1186/s12938-015-0033-5 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1186/s12938-015-0033-5 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 31 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 14 es_ES
dc.description.issue 35 es_ES
dc.relation.senia 292134 es_ES
dc.identifier.pmid 25928297 en_EN
dc.identifier.pmcid PMC4424572
dc.contributor.funder Ministerio de Economía y Competitividad
dc.contributor.funder Generalitat Valenciana
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
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