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The causes of epistasis

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dc.contributor.author de Visser, J. Arjan G. M. es_ES
dc.contributor.author Cooper, Tim F. es_ES
dc.contributor.author Elena Fito, Santiago Fco es_ES
dc.date.accessioned 2017-06-21T07:15:10Z
dc.date.available 2017-06-21T07:15:10Z
dc.date.issued 2011-12-22
dc.identifier.issn 0962-8452
dc.identifier.uri http://hdl.handle.net/10251/83307
dc.description.abstract [EN] Since Bateson's discovery that genes can suppress the phenotypic effects of other genes, gene interactions-called epistasis-have been the topic of a vast research effort. Systems and developmental biologists study epistasis to understand the genotype-phenotype map, whereas evolutionary biologists recognize the fundamental importance of epistasis for evolution. Depending on its form, epistasis may lead to divergence and speciation, provide evolutionary benefits to sex and affect the robustness and evolvability of organisms. That epistasis can itself be shaped by evolution has only recently been realized. Here, we review the empirical pattern of epistasis, and some of the factors that may affect the form and extent of epistasis. Based on their divergent consequences, we distinguish between interactions with or without mean effect, and those affecting the magnitude of fitness effects or their sign. Empirical work has begun to quantify epistasis in multiple dimensions in the context of metabolic and fitness landscape models. We discuss possible proximate causes (such as protein function and metabolic networks) and ultimate factors (including mutation, recombination, and the importance of natural selection and genetic drift). We conclude that, in general, pleiotropy is an important prerequisite for epistasis, and that epistasis may evolve as an adaptive or intrinsic consequence of changes in genetic robustness and evolvability. es_ES
dc.description.sponsorship We thank Fons Debets, Ryszard Korona, Alexey Kondrashov, Joachim Krug, Sijmen Schoustra and an anonymous reviewer for constructive comments, and funds from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement 225167 (eFLUX), a visitor grant from Research School Production Ecology and Resource Conservation for S.F.E., and NSF grant DEB-0844355 for T.F.C.
dc.language Inglés es_ES
dc.publisher Royal Society, The es_ES
dc.relation.ispartof Proceedings of the Royal Society B: Biological Sciences es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Epistasis es_ES
dc.subject Pleiotropy es_ES
dc.subject Robustness es_ES
dc.subject Evolvability es_ES
dc.title The causes of epistasis es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1098/rspb.2011.1537
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/225167/EU/Evolutionary microfluidics/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NSF//0844355/US/Collaborative Research: Understanding the basis of interactions between adaptive mutations and their environment/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation De Visser, JAGM.; Cooper, TF.; Elena Fito, SF. (2011). The causes of epistasis. Proceedings of the Royal Society B: Biological Sciences. 278(1725):3617-3624. https://doi.org/10.1098/rspb.2011.1537 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1098/rspb.2011.1537 es_ES
dc.description.upvformatpinicio 3617 es_ES
dc.description.upvformatpfin 3624 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 278 es_ES
dc.description.issue 1725 es_ES
dc.relation.senia 218208 es_ES
dc.identifier.pmid 21976687
dc.identifier.pmcid PMC3203509 en_EN
dc.contributor.funder European Commission
dc.contributor.funder National Science Foundation, EEUU
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