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Influence of synthesis parameters on hyaluronic acid hydrogels intended as nerve conduits

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Influence of synthesis parameters on hyaluronic acid hydrogels intended as nerve conduits

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dc.contributor.author Ortuño-Lizarán, Isabel es_ES
dc.contributor.author Vilariño, Guillermo es_ES
dc.contributor.author Martínez-Ramos, Cristina es_ES
dc.contributor.author Monleón Pradas, Manuel es_ES
dc.contributor.author Vallés Lluch, Ana es_ES
dc.date.accessioned 2018-02-22T05:24:31Z
dc.date.available 2018-02-22T05:24:31Z
dc.date.issued 2016 es_ES
dc.identifier.issn 1758-5082 es_ES
dc.identifier.uri http://hdl.handle.net/10251/98274
dc.description.abstract [EN] Hydrogels have widely been proposed lately as strategies for neural tissue regeneration, but there are still some issues to be solved before their efficient use in tissue engineering of trauma, stroke or the idiopathic degeneration of the nervous system. In a previous work of the authors a novel Schwann-cell structure with the shape of a hollow cylinder was obtained using a three-dimensional conduit based in crosslinked hyaluronic acid as template. This original engineered tissue of tightly joined Schwann cells obtained in a conduit lumen having 400 mu m in diameter is a consequence of specific cell-material interactions. In the present work we analyze the influence of the hydrogel concentration and of the drying process on the physicochemical and biological performance of the resulting tubular scaffolds, and prove that the cylinder-like cell sheath obtains also in scaffolds of a larger inner diameter. The diffusion of glucose and of the protein BSA through the scaffolds is studied and characterized, as well as the enzymatic degradation kinetics of the lyophilized conduits. This can be modulated from a couple of weeks to several months by varying the concentration of hyaluronic acid in the starting solution. These findings allow to improve the performance of hyaluronan intended for neural conduits, and open the way to scaffolds with tunable degradation rate adapted to the site and severity of the injury. es_ES
dc.description.sponsorship The authors acknowledge Spanish Ministerio de Ciencia e Innovacion through projects PRI-PIMNEU-2011-1372 (ERANET-Neuron), MAT2011-28791-C03-02 and -03. I. Ortuno Lizaran acknowledges support by CIBER-BBN starting grant. es_ES
dc.language Inglés es_ES
dc.publisher IOP Publishing es_ES
dc.relation.ispartof Biofabrication es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Hyaluronan es_ES
dc.subject Scaffold es_ES
dc.subject Nerve conduit es_ES
dc.subject Schwann cell es_ES
dc.subject Degradability es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Influence of synthesis parameters on hyaluronic acid hydrogels intended as nerve conduits es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1088/1758-5090/8/4/045011 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//PRI-PIMNEU-2011-1372/ES/MATERIALES BIFUNCIONALES PARA LA REGENERACION NEURAL DE AREAS AFECTADAS POR ICTUS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//MAT2011-28791-C03-02/ES/MATERIALES DE SOPORTE Y LIBERACION CONTROLADA PARA LA REGENERACION DE ESTRUCTURAS NEURALES AFECTADAS POR ICTUS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//MAT2011-28791-C03-03/ES/CONSTRUCTOS PARA LA REGENERACION GUIADA DE ESTRUCTURAS DEL SISTEMA NERVIOSO CENTRAL/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Ortuño-Lizarán, I.; Vilariño, G.; Martínez-Ramos, C.; Monleón Pradas, M.; Vallés Lluch, A. (2016). Influence of synthesis parameters on hyaluronic acid hydrogels intended as nerve conduits. Biofabrication. 8(4):1-12. https://doi.org/10.1088/1758-5090/8/4/045011 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1088/1758-5090/8/4/045011 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 12 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 8 es_ES
dc.description.issue 4 es_ES
dc.relation.pasarela S\325385 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
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