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Browsing by Author "Lérida Viso, Araceli"

Now showing items 1-6 of 6

Biosafety of mesoporous silica nanoparticles; towards clinical translation

Lérida-Viso, Araceli; Estepa-Fernández, Alejandra; García-Fernández, Alba; Martí-Centelles, Vicente; Martínez-Máñez, Ramón (Elsevier, 2023-10)

[EN] Mesoporous silica nanoparticles (MSNs) have attracted the attention of chemists, who have developed numerous systems for the encapsulation of a plethora of molecules, allowing the use of mesoporous silica nanoparticles ...
Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer

Estepa-Fernández, Alejandra; García-Fernández, Alba; Lerida-Viso, Araceli; Blandez, Juan F.; Galiana, Irene; Sancenón Galarza, Félix; Orzaez, Mar; Martínez-Máñez, Ramón (Elsevier, 2023-01)

[EN] Triple-negative breast cancer (TNBC) is a very aggressive subtype of breast cancer with a poor prognosis and limited effective therapeutic options. Induction of senescence, arrest of cell proliferation, has been ...
Evaluación in vitro de nuevos agentes fotosensibilizantes con aplicación en terapia fotodinámica para el tratamiento del melanoma humano

Estellés Díaz, Carlos (Universitat Politècnica de València, 2020-07-24)

[ES] El melanoma, originado en los melanocitos, es un tipo de cáncer de piel invasivo, con alta tendencia a metastatizar y que presenta una elevada resistencia a fármacos. En la actualidad, los tratamientos convencionales ...
Pharmacological Senolysis as a New Therapeutic Approach for the Prevention of Doxorubicin-Induced Cardiotoxicity

Lérida Viso, Araceli (Universitat Politècnica de València, 2023-07-06)

[ES] La presente tesis doctoral titulada "La terapia senolítica como nuevo enfoque terapéutico para la prevención de la cardiotoxicidad inducida por la doxorrubicina" se centra en explorar la eliminación de células senescentes ...
Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice

Lerida-Viso, Araceli; Estepa-Fernández, Alejandra; Morella-Aucejo, Ángela; Lozano-Torres, Beatriz; Alfonso, María; Blandez, Juan F.; Bisbal, Viviana; Sepúlveda, Pilar; García-Fernández, Alba; Orzáez, Mar; Martínez-Máñez, Ramón (Elsevier, 2022-09)

[EN] Many anticancer agents used in clinics induce premature senescence in healthy tissues generating accelerated aging processes and adverse side-effects in patients. Cardiotoxicity is a well-known limiting factor of ...
Phosphorogenic dipyrrinato-iridium(III) complexes as photosensitizers for photodynamic therapy

Prieto-Castañeda, A.; Lérida-Viso, A.; Avellanal-Zaballa, E.; Sola-Llano, R.; Bañuelos, J.; Agarrabeitia, A.R.; Martínez-Máñez, Ramón; Ortiz, M.J. (Elsevier, 2022-01)

[EN] We have designed and synthesized a family of Ir(III) metal complexes coordinated with two cyclometalated bisfluorophenylpyridine ligands and an ancillary dipyrromethene which is functionalized with a mesityl group (Ir ...