Amaro Prellezo, Elena

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Subject: Angiogenesis ×

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    Topical Administration of a Marine Oil Rich in Pro-Resolving Lipid Mediators Accelerates Wound Healing in Diabetic db/db Mice through Angiogenesis and Macrophage Polarization
    (MDPI AG, 2022-08-31) Amaro Prellezo, Elena; Ontoria-Oviedo, Imelda; Castellano, Delia; Venegas-Venegas, Elena; González-Santos, Fernando; Ruiz-Saurí, Amparo; Pelacho, Beatriz; Prósper, Felipe; Pérez del Caz, María Dolores; Sepúlveda, Pilar; Centro de Biomateriales e Ingeniería Tisular; Instituto de Salud Carlos III; European Regional Development Fund; Ministerio de Economía y Competitividad; Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana
    [EN] Impaired wound healing in patients with type 2 diabetes (DM2) is characterized by chronic inflammation, which delays wound closure. Specialized pro-resolving lipid mediators (SPMs) are bioactive molecules produced from essential polyunsaturated fatty acids (PUFAs), principally omega-3 docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). SPMs are potent regulators of inflammation and have been used to suppress chronic inflammation in peripheral artery disease, non-alcoholic fatty liver disease, and central nervous system syndromes. LIPINOVA® is a commercially available safe-grade nutritional supplement made from a fractionated marine lipid concentrate derived from anchovy and sardine oil that is rich in SPMs and EPA, as well as DHA precursors. Here, we assessed the effect of LIPINOVA® in wound dressing applications. LIPINOVA® showed biocompatibility with keratinocytes and fibroblasts, reduced the abundance of pro-inflammatory macrophages (M¿1), and promoted in vitro wound closure. Daily application of the marine oil to open wounds made by punch biopsy in db/db mice promoted wound closure by accelerating the resolution of inflammation, inducing neoangiogenesis and M¿1/M¿2 macrophage polarization. In conclusion, LIPINOVA® displays pro-resolutive properties and could be exploited as a therapeutic agent for the treatment of diabetic ulcers.