Benlloch Baviera, Jose María
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- PublicationScanner calibration of a small animal PET camera based on continuous LSO crystals and flat panel PSPMTs(Elsevier, 2007-02-01) Benlloch Baviera, Jose María; Carrilero, V.; González Martínez, Antonio Javier; Catret, J.; Lerche, Christoph Werner; Abellan, D.; García de Quiros, F.; Gimenez, M.; Modia, J.; Sánchez, Filomeno; Ros García, Ana; Martínez, J.; Sebastia Cortes, Angel; Instituto de Instrumentación para Imagen Molecular[EN] We have constructed a small animal PET with four identical detector modules, each consisting of a continuous LYSO crystal attached to a Position Sensitive Photomultiplier Tube (PSPMT). The dimensions of the continuous crystal are 50 x 50 mm 2 and 10 mm thickness. The modules are separated 11 cm between each other in the scanner. In this paper we discuss the method used for the calibration of the camera for this special system with continuous detectors. We also present the preliminary values for the main performance parameters such as spatial and energy resolution, and sensitivity of the system. (c) 2006 Elsevier B.V. All rights reserved.
- PublicationPerformance of a DOI-encoding small animal PET system with monolithic scintillators(Elsevier, 2012-12-11) Carles Fariña, Montserrat; Lerche, Christoph Werner; Sánchez Martínez, Filomeno; Orero Palomares, Abel; Moliner Martínez, Laura; Soriano Asensi, Antonio; Benlloch Baviera, Jose María; Instituto de Instrumentación para Imagen MolecularPET systems designed for specific applications require high resolution and sensitivity instrumentation. In dedicated system design smaller ring diameters and deeper crystals are widely used in order to increase the system sensitivity. However, this design increases the parallax error, which degrades the spatial image resolution gradually from the center to the edge of the field-of-view (FOV). Our group has designed a depth of interaction(DOI)-encoding small animal PET system based on monolithic crystals. In this work we investigate the restoration of radial resolution for transaxially off-center sources using the DOI information provided by our system. For this purpose we have designed a support for point like sources adapted to our system geometry that allows a spatial compression and resolution response study. For different point source radial positions along vertical and horizontal axes of a FOV transaxial plane we compare the results obtained by three methods: without DOI information, with the DOI provided by our system and with the assumption that all the ¿-rays interact at half depth of the crystal thickness. Results show an improvement of the mean resolution of 10% with the half thickness assumption and a 16% achieved using the DOI provided by the system. Furthermore, a 10% restoration of the resolution uniformity is obtained using the half depth assumption and an 18% restoration using measured DOI. © 2011 Elsevier B.V.
- PublicationBuilding blocks of a multi-layer PET with time sequence photon interaction discrimination and double Compton camera(Elsevier, 2018) Ilisie, V.; Giménez-Alventosa, Vicent; Moliner Martínez, Laura; Sánchez Martínez, Filomeno; González Martínez, Antonio Javier; Rodríguez Álvarez, María José; Benlloch Baviera, Jose María; Departamento de Matemática Aplicada; Escuela Técnica Superior de Ingeniería Informática; Instituto de Instrumentación para Imagen Molecular; Ministerio de Economía y Competitividad; European Commission[EN] Current PET detectors have a very low sensitivity, of the order of a few percent. One of the reasons is the fact that Compton interactions are rejected. If an event involves multiple Compton scattering and the total deposited energy lays within the photoelectric peak, then an energy-weighted centroid is the given output for the coordinates of the reconstructed interaction point. This introduces distortion in the final reconstructed image. The aim of our work is to prove that Compton events are a very rich source of additional information as one can improve the resolution of the detector and implicitly the final reconstructed image. This could be a real breakthrough for PET detector technology as one should be able to obtain better results with less patient radiation. Using a PET as a double Compton camera, by means of Compton cone matching i.e., Compton cones coming from the same event should be compatible, is applied to discard randoms, patient scattered events and also, to perform a correct matching among events with multiple coincidences. In order to fully benefit experimentally from Compton events using monolithic scintillators a multi-layer configuration is needed and a good time-of-flight resolution.
- PublicationDesign and first results of an innovative and dedicated for hanging breast imaging PET(Bentham Science Publishers, 2012-05-01) González Martínez, Antonio Javier; S Aukema, T.; Barberá Ballester, Julio; Benlloch Baviera, Jose María; Correcher Salvador, Carlos; Orero Palomares, Abel; Soriano Asensi, Antonio; Vogel, W.; Vazquez Barreiros, Carlos; Vidal San Sebastián, Luis Fernando; Valdes Olmos, A.R.; Instituto de Instrumentación para Imagen MolecularIn this work the design and preliminary clinical results obtained with an innovative and dedicated breast PET is presented. A geometrical study clearly pointed out the advantages of the prone position and the technique of hanging breast in comparison to the supine, conventionally used for other imaging modalities. Occult, multifocal and also lesions close to the pectoral muscle were depicted by means of the prone method. The measured diameters of the hanging breasts allowed us to define an optimum transaxial FOV of up to 170 mm. This was achieved by means of 12 detector heads mounted on ring geometry, each using a monolithic LYSO crystal a position sensitive photomultiplier, among other components. The detector showed up an extrinsic spatial resolution as high as 1.4 mm in the center of the FOV with a physical sensitivity of 1.2 %. A clinical trial is undergoing at the Netherlands Cancer Institute in terms of a clinical validation of the dedicated breast PET. An adequate image matching between this device and the whole-body PET was observed, even for deep chest lesions. A preliminary quantitative comparison also shows a good agreement between both systems. However, a tiny deviation to higher Standard Uptake Values is observed for the prototype.
- PublicationPosition correction with depth of interaction information for a small animal PET system(Elsevier, 2011) Carles, M.; Lerche, Christoph Werner; Sánchez Martínez, Filomeno; Mora Mas, Francisco José; Benlloch Baviera, Jose María; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería de Telecomunicación; Instituto de Instrumentación para Imagen Molecular[EN] In this work we study the effects on the spatial resolution when depth of interaction (001) information is included in the parameterization of the line of response (LOR) for a small animal positron emission tomography (PET) system. One of the most important degrading factors for PET is the parallax error introduced in systems that do not provide DOI information of the recorded gamma-rays. Our group has designed a simple and inexpensive method for DOI determination in continuous scintillation crystals. This method is based, on one hand, in the correlation between the scintillation light distribution width in monolithic crystals and the DOI, and, on the other hand, on a small modification of the widely applied charge dividing circuits (CDR). In this work we present a new system calibration that includes the DOI information, and also the development of the correction equations that relates the LOR without and with DOI information. We report the results obtained for different measurements along the transaxial field of view (FOV) and the image quality enhancement achieved specially at the edge of the FOV. (C) 2010 Elsevier B.V. All rights reserved.
- PublicationImplementation and analysis of list mode algorithm using tubes of response on a dedicated brain and breast PET(Elsevier, 2013-02-21) Moliner Martínez, Laura; Correcher, Carlos; González Martínez, Antonio Javier; Conde Castellanos, Pablo Eloy; Hernández Hernández, Liczandro; Orero Palomares, Abel; Rodríguez Álvarez, María José; Sánchez Martínez, Filomeno; Soriano Asensi, Antonio; Vidal San Sebastián, Luis Fernando; Benlloch Baviera, Jose María; Departamento de Matemática Aplicada; Escuela Técnica Superior de Ingeniería Informática; Instituto de Instrumentación para Imagen Molecular; Ministerio de Ciencia e Innovación; Generalitat Valenciana; Centro para el Desarrollo Tecnológico IndustrialIn this work we present an innovative algorithm for the reconstruction of PET images based on the List-Mode (LM) technique which improves their spatial resolution compared to results obtained with current MLEM algorithms. This study appears as a part of a large project with the aim of improving diagnosis in early Alzheimer disease stages by means of a newly developed hybrid PET-MR insert. At the present, Alzheimer is the most relevant neurodegenerative disease and the best way to apply an effective treatment is its early diagnosis. The PET device will consist of several monolithic LYSO crystals coupled to SiPM detectors. Monolithic crystals can reduce scanner costs with the advantage to enable implementation of very small virtual pixels in their geometry. This is especially useful for LM reconstruction algorithms, since they do not need a pre-calculated system matrix. We have developed an LM algorithm which has been initially tested with a large aperture (186 mm) breast PET system. Such an algorithm instead of using the common lines of response, incorporates a novel calculation of tubes of response. The new approach improves the volumetric spatial resolution about a factor 2 at the border of the field of view when compared with traditionally used MLEM algorithm. Moreover, it has also shown to decrease the image noise, thus increasing the image quality. © 2012 Elsevier B.V. All rights reserved.
- PublicationDiseño y primeros resultados de una cámara PET para animales pequeños basada en cristales LYSO continuos y fotomulplicadores sensibles a la posición(Sociedad Española de Física Médica, 2007) Benlloch Baviera, Jose María; González Martínez, Antonio Javier; Carrilero, V.; Catret, J. V.; Correcher, C.; Lerche, Christoph Werner; Morera, C.; Orero, A.; Pavón, N.; Ros García, Ana; Sánchez, F.; Soriano Asensi, Antonio; Vidal San Sebastián, Luis Fernando; Colom Palero, Ricardo José; Gadea Gironés, Rafael; Herrero Bosch, Vicente; Mora, C.; Mora Mas, Francisco José; Sebastia Cortes, Angel; Munar, A.; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería de Telecomunicación; Instituto de Instrumentación para Imagen Molecular[ES] En este artículo presentamos el diseño de un nuevo escáner PET para animales pequeños basado en una tecnología completamente innovadora. Los resultados preliminares son muy prometedores, permitiendo obtener imágenes funcionales de alta resolución con una instrumentación compacta y de bajo coste. Los prototipos desarrollados se encuentran actualmente en pruebas en diversos centros de investigación médica, obteniéndose imá- genes de alta calidad en los campos de oncología, neurología y cardiología. Este diseño puede ser fácilmente extendido a cámaras PET dedicadas a la exploración del cerebro o de la mama. La innovación más notable de la presente tecnología consiste en el uso de un único cristal continuo por módulo, a diferencia de otras cámaras PET comerciales donde se utilizan cientos de cristales pixelados. El uso de un único cristal continuo permite abaratar el coste de fabricación, al tiempo que mejora las características de funcionamiento: resolución intrínseca en posición de 1,2 mm, resolución en energía media del 14%, resolución en la profundidad de interacción de 3 mm, sensibilidad > 4% y campo de visión transaxial de 80 mm de diámetro. En el presente artículo se describen en detalle el diseño de esta nueva cámara PET, los principios de funcionamiento, el método utilizado para su calibración y se anticipan algunas imágenes "in vivo" del miocardio y el cerebro de un ratón, permitiendo apreciar de forma preliminar la resolución y calidad alcanzadas.