Characterisation and functional analysis of the WIF1 gene and its role in hair follicle growth and development of the Angora rabbit

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dc.contributor.authorZhao, Bohaoes_ES
dc.contributor.authorLi, Jialies_ES
dc.contributor.authorZhang, Xiyues_ES
dc.contributor.authorBao, Zhiyuanes_ES
dc.contributor.authorChen, Yanges_ES
dc.contributor.authorWu, Xinshenges_ES
dc.contributor.funderNational Natural Science Foundation of Chinaes_ES
dc.date.accessioned2022-10-10T07:12:05Z
dc.date.available2022-10-10T07:12:05Z
dc.date.issued2022-09-30
dc.description.abstract[EN] Growth and development of hair follicles (HF) is a complex and dynamic process in most mammals. As HF growth and development regulate rabbit wool yield, exploring the role of genes involved in HF growth and development may be relevant. In this study, the coding sequence of the Angora rabbit (Oryctolagus cuniculus) WIF1 gene was cloned. The length of the coding region sequence was found to be 1140 bp, which encodes 379 amino acids. Bioinformatics analysis indicated that the WIF1 protein was unstable, hydrophilic and located in the extracellular region, contained a putative signal peptide and exhibited a high homology in different mammals. Moreover, WIF1 was significantly downregulated in the high wool production in the Angora rabbit group. Overexpression and knockdown studies revealed that WIF1 regulates HF growth and development-related genes and proteins, such as LEF1 and CCND1. WIF1 activated β-catenin/TCF transcriptional activity, promoted cell apoptosis and inhibited cellular proliferation. These results indicate that WIF1 might be important for HF development. This study, therefore, provides a theoretical foundation for investigating WIF1 in HF growth and development.en_EN
dc.description.accrualMethodOJSes_ES
dc.description.bibliographicCitationZhao, B.; Li, J.; Zhang, X.; Bao, Z.; Chen, Y.; Wu, X. (2022). Characterisation and functional analysis of the WIF1 gene and its role in hair follicle growth and development of the Angora rabbit. World Rabbit Science. 30(3):209-218. https://doi.org/10.4995/wrs.2022.17353es_ES
dc.description.issue3es_ES
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dc.description.sponsorshipThis research was funded by This research was funded by National Natural Science Foundation of China (Grant No. 32102529), China Agriculture Research System of MOF and MARA (CARS-43-A-1).es_ES
dc.description.upvformatpfin218es_ES
dc.description.upvformatpinicio209es_ES
dc.description.volume30es_ES
dc.identifier.doi10.4995/wrs.2022.17353
dc.identifier.eissn1989-8886
dc.identifier.issn1257-5011
dc.identifier.urihttps://riunet.upv.es/handle/10251/187317
dc.languageIngléses_ES
dc.publisherUniversitat Politècnica de Valènciaes_ES
dc.relation.ispartofWorld Rabbit Sciencees_ES
dc.relation.pasarelaOJS\17353es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/NSFC//32102529es_ES
dc.relation.publisherversionhttps://doi.org/10.4995/wrs.2022.17353es_ES
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dc.rightsReconocimiento - No comercial - Compartir igual (by-nc-sa)es_ES
dc.rights.accessRightsAbiertoes_ES
dc.subjectRabbites_ES
dc.subjectWIF1es_ES
dc.subjectAngora rabbites_ES
dc.subjectHair folliclees_ES
dc.subjectBioinformaticses_ES
dc.subjectWnt signalling pathwayes_ES
dc.titleCharacterisation and functional analysis of the WIF1 gene and its role in hair follicle growth and development of the Angora rabbites_ES
dc.typeArtículoes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dspace.entity.typePublication
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