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dc.contributor.author | Vayá Pérez, Ignacio | es_ES |
dc.contributor.author | Bueno Alejo, Carlos Javier | es_ES |
dc.contributor.author | Jiménez Molero, María Consuelo | es_ES |
dc.contributor.author | Miranda Alonso, Miguel Ángel | es_ES |
dc.date.accessioned | 2018-04-08T04:08:49Z | |
dc.date.available | 2018-04-08T04:08:49Z | |
dc.date.issued | 2006 | es_ES |
dc.identifier.issn | 1860-7179 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/100064 | |
dc.description.abstract | [EN] The triplet excited states of (S)- and (R)-flurbiprofen (FBP) have been used as reporters for the microenvironments experienced within the binding sites of human and bovine serum albumins. Regression analysis of triplet decay provides valuable information on the degree of protection that these excited states are afforded from attack by a second FBP molecule, oxygen, or other reagents. The multiexponential fitting of these decays can be satisfactorily correlated with the distribution of the drug among the two binding sites and its presence as the noncomplexed form in the bulk solution. This assignment has been confirmed by using (S)-ibuprofen or capric acid as selective site II replacement probes. Triplet lifetimes and site occupancy are sensitive to the type of serum albumin employed (human versus bovine). Finally, the binding behaviour of (S)- and (R)-FBP exhibits little stereoselectivity. | es_ES |
dc.description.sponsorship | Financial support from the MCYT (CTQ2004-03811) and the Generalitat Valenciana (GV06/099) isgratefully acknowledged. I.V. and C.J.B. thank “Ministerio de Educación y Ciencia” for a fellowship. | |
dc.language | Inglés | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.relation.ispartof | ChemMedChem | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject.classification | QUIMICA ANALITICA | es_ES |
dc.subject.classification | QUIMICA ORGANICA | es_ES |
dc.title | Use of triplet excited states for the study of drug binding to human and bovine serum albumins | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1002/cmdc.200600061 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//CTQ2004-03811/ES/ INTERACCIONES FARMACO-BIOMOLECULA EN LOS ESTADOS EXCITADOS./ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//GV06%2F099/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Química - Departament de Química | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic | es_ES |
dc.description.bibliographicCitation | Vayá Pérez, I.; Bueno Alejo, CJ.; Jiménez Molero, MC.; Miranda Alonso, MÁ. (2006). Use of triplet excited states for the study of drug binding to human and bovine serum albumins. ChemMedChem. 1(9):1015-1020. https://doi.org/10.1002/cmdc.200600061 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1002/cmdc.200600061 | es_ES |
dc.description.upvformatpinicio | 1015 | es_ES |
dc.description.upvformatpfin | 1020 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 1 | es_ES |
dc.description.issue | 9 | es_ES |
dc.relation.pasarela | S\29815 | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Ministerio de Educación y Ciencia |