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dc.contributor.author | Dos Santos, S.N. | es_ES |
dc.contributor.author | Rezende Dos Reis, S.R. | es_ES |
dc.contributor.author | Pires, L.P | es_ES |
dc.contributor.author | Helal-Neto, E. | es_ES |
dc.contributor.author | Sancenón Galarza, Félix | es_ES |
dc.contributor.author | Barja-Fidalgo, T.C. | es_ES |
dc.contributor.author | Medina De Mattos, R. | es_ES |
dc.contributor.author | Nasciutti, L.E. | es_ES |
dc.contributor.author | Martínez-Máñez, Ramón | es_ES |
dc.contributor.author | Santos-Oliveira, R. | es_ES |
dc.date.accessioned | 2018-04-19T12:40:31Z | |
dc.date.available | 2018-04-19T12:40:31Z | |
dc.date.issued | 2017 | es_ES |
dc.identifier.issn | 1387-1811 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/100718 | |
dc.description.abstract | [EN] The mononuclear phagocytic system is a key participant determining the half-life of nanoparticles (NPs) in the bloodstream and influencing active targeting. Several strategies to extend the circulation time of nanoparticles and to reduce MPS (Mononuclear Phagocyte System) uptake have been developed so far. Here we evaluated the potential of albumin coated-mesoporous silica nanoparticles to overcome MPS clearance in a mouse model of endometrioses. We found that human albumin bath was able to reduce unspecific uptake by liver and spleen but reduced accumulation of NPs to endometriosis site. Our data suggest that although human albumin bath may help to overcome MPS clearance of NPs, it affects NPs uptake by the target site. (C) 2017 Elsevier Inc. All rights reserved. | es_ES |
dc.description.sponsorship | The authors would like to thank the National Scientific and Technological Research Council (CNPQ) and the Rio de Janeiro State Research Foundation (FAPERJ) for funding.Authors also gratefully acknowledge the financial support from the Ministerio de Economia y Competitividad (Project MAT2012-38429-004-01) and the Generalitat Valenciana (project PROMETEO/2009/016) for support. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | Microporous and Mesoporous Materials | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Nanoparticles | es_ES |
dc.subject | Mononuclear phagocyte system | es_ES |
dc.subject | Mesoporous silica | es_ES |
dc.subject | Smart device | es_ES |
dc.subject | Hidden system | es_ES |
dc.subject.classification | QUIMICA INORGANICA | es_ES |
dc.subject.classification | QUIMICA ORGANICA | es_ES |
dc.title | Avoiding the mononuclear phagocyte system using human albumin for mesoporous silica nanoparticle system | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.micromeso.2017.06.005 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/Generalitat Valenciana//PROMETEO09%2F2009%2F016/ES/Ayuda prometeo 2009 para el grupo de diseño y desarrollo de sensores/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//MAT2012-38429-C04-01/ES/DESARROLLO DE MATERIALES FUNCIONALIZADOS CON PUERTAS NANOSCOPICAS PARA APLICACIONES DE LIBERACION CONTROLADA Y SENSORES PARA LA DETECCION DE NITRATO AMONICO, SULFIDRICO Y CO/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Química - Departament de Química | es_ES |
dc.description.bibliographicCitation | Dos Santos, S.; Rezende Dos Reis, S.; Pires, L.; Helal-Neto, E.; Sancenón Galarza, F.; Barja-Fidalgo, T.; Medina De Mattos, R.... (2017). Avoiding the mononuclear phagocyte system using human albumin for mesoporous silica nanoparticle system. Microporous and Mesoporous Materials. 251:181-189. https://doi.org/10.1016/j.micromeso.2017.06.005 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.micromeso.2017.06.005 | es_ES |
dc.description.upvformatpinicio | 181 | es_ES |
dc.description.upvformatpfin | 189 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 251 | es_ES |
dc.relation.pasarela | S\341412 | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |