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Avoiding the mononuclear phagocyte system using human albumin for mesoporous silica nanoparticle system

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Avoiding the mononuclear phagocyte system using human albumin for mesoporous silica nanoparticle system

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dc.contributor.author Dos Santos, S.N. es_ES
dc.contributor.author Rezende Dos Reis, S.R. es_ES
dc.contributor.author Pires, L.P es_ES
dc.contributor.author Helal-Neto, E. es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Barja-Fidalgo, T.C. es_ES
dc.contributor.author Medina De Mattos, R. es_ES
dc.contributor.author Nasciutti, L.E. es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Santos-Oliveira, R. es_ES
dc.date.accessioned 2018-04-19T12:40:31Z
dc.date.available 2018-04-19T12:40:31Z
dc.date.issued 2017 es_ES
dc.identifier.issn 1387-1811 es_ES
dc.identifier.uri http://hdl.handle.net/10251/100718
dc.description.abstract [EN] The mononuclear phagocytic system is a key participant determining the half-life of nanoparticles (NPs) in the bloodstream and influencing active targeting. Several strategies to extend the circulation time of nanoparticles and to reduce MPS (Mononuclear Phagocyte System) uptake have been developed so far. Here we evaluated the potential of albumin coated-mesoporous silica nanoparticles to overcome MPS clearance in a mouse model of endometrioses. We found that human albumin bath was able to reduce unspecific uptake by liver and spleen but reduced accumulation of NPs to endometriosis site. Our data suggest that although human albumin bath may help to overcome MPS clearance of NPs, it affects NPs uptake by the target site. (C) 2017 Elsevier Inc. All rights reserved. es_ES
dc.description.sponsorship The authors would like to thank the National Scientific and Technological Research Council (CNPQ) and the Rio de Janeiro State Research Foundation (FAPERJ) for funding.Authors also gratefully acknowledge the financial support from the Ministerio de Economia y Competitividad (Project MAT2012-38429-004-01) and the Generalitat Valenciana (project PROMETEO/2009/016) for support. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation info:eu-repo/grantAgreement/Generalitat Valenciana//PROMETEO09%2F2009%2F016/ES/Ayuda prometeo 2009 para el grupo de diseño y desarrollo de sensores/ es_ES
dc.relation MINECO/MAT2012-38429-C04-01 es_ES
dc.relation.ispartof Microporous and Mesoporous Materials es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Nanoparticles es_ES
dc.subject Mononuclear phagocyte system es_ES
dc.subject Mesoporous silica es_ES
dc.subject Smart device es_ES
dc.subject Hidden system es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Avoiding the mononuclear phagocyte system using human albumin for mesoporous silica nanoparticle system es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.micromeso.2017.06.005 es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Dos Santos, S.; Rezende Dos Reis, S.; Pires, L.; Helal-Neto, E.; Sancenón Galarza, F.; Barja-Fidalgo, T.; Medina De Mattos, R.... (2017). Avoiding the mononuclear phagocyte system using human albumin for mesoporous silica nanoparticle system. Microporous and Mesoporous Materials. 251:181-189. https://doi.org/10.1016/j.micromeso.2017.06.005 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.micromeso.2017.06.005 es_ES
dc.description.upvformatpinicio 181 es_ES
dc.description.upvformatpfin 189 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 251 es_ES
dc.relation.pasarela S\341412 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES


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